Serological evidence of hepatitis E virus infection in zoo animals and identification of a rodent-borne strain in a Syrian brown bear
Hepatitis E virus (HEV) is the causative agent of hepatitis E, an emerging infectious disease of humans. HEV infections have also been described in various animal species. Whereas domestic pigs and wild boars are well-known animal reservoirs for HEV, the knowledge on natural HEV infection in zoo ani...
Published in: | Veterinary Microbiology |
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2017
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Online Access: | https://doi.org/10.1016/j.vetmic.2017.11.005 https://www.openagrar.de/receive/openagrar_mods_00032193 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00007334/SD2017536.pdf https://www.sciencedirect.com/science/article/pii/S0378113517309768 |
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ftopenagrar:oai:www.openagrar.de:openagrar_mods_00032193 2024-09-15T18:40:11+00:00 Serological evidence of hepatitis E virus infection in zoo animals and identification of a rodent-borne strain in a Syrian brown bear Spahr, C. Ryll, René Knauf-Witzens, T. Vahlenkamp, T. W. Ulrich, Rainer Johne, Reimar 2017-11-09 https://doi.org/10.1016/j.vetmic.2017.11.005 https://www.openagrar.de/receive/openagrar_mods_00032193 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00007334/SD2017536.pdf https://www.sciencedirect.com/science/article/pii/S0378113517309768 eng eng Veterinary microbiology -- Vet. Microbiol. -- 1873-2542 -- 0378-1135 -- 1498996-7 -- 753154-0 -- http://www.sciencedirect.com/science/journal/03781135 -- http://www.bibliothek.uni-regensburg.de/ezeit/?1498996 https://doi.org/10.1016/j.vetmic.2017.11.005 https://www.openagrar.de/receive/openagrar_mods_00032193 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00007334/SD2017536.pdf https://www.sciencedirect.com/science/article/pii/S0378113517309768 only signed in user all rights reserved info:eu-repo/semantics/restrictedAccess Text article ddc:570 Hepatitis E virus -- zoo animals -- cross-species transmission -- Syrian brown bear (Ursus arctos syriacus) -- Norway rat (Rattus norvegicus) article Text doc-type:article 2017 ftopenagrar https://doi.org/10.1016/j.vetmic.2017.11.005 2024-07-08T23:56:25Z Hepatitis E virus (HEV) is the causative agent of hepatitis E, an emerging infectious disease of humans. HEV infections have also been described in various animal species. Whereas domestic pigs and wild boars are well-known animal reservoirs for HEV, the knowledge on natural HEV infection in zoo animals is scarce so far. Here, we analysed 244 sera from 66 mammal species derived from three zoos in Germany using a commercial double antigen sandwich ELISA. HEV-specific antibodies were detected in 16 animal species, with the highest detection rates in suids (33.3%) and carnivores (27.0%). However, RNA of the human pathogenic HEV genotypes 1 to 4 was not detected in the serum samples from suids or carnivores. Using a broad spectrum RT-PCR, a ratHEV-related sequence was identified in a sample of a female Syrian brown bear (Ursus arctos syriacus). Subsequent serum samples within a period of five years confirmed a HEV seroconversion in this animal. No symptoms of hepatitis were recorded. In a follow-up investigation at the same location, closely related ratHEV sequences were identified in free-living Norway rats (Rattus norvegicus), whereas feeder rats (Rattus norvegicus forma domestica) were negative for HEV-specific antibodies and RNA. Therefore, a spillover infection of ratHEV from free-living Norway rats is most likely. The results indicate that a wide range of zoo animals can be naturally infected with HEV or HEV-related viruses. Their distinct role as possible reservoir animals for HEV and sources of HEV infection for humans and other animals remains to be investigated. Article in Journal/Newspaper Ursus arctos OpenAgrar (OA) Veterinary Microbiology 212 87 92 |
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English |
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Text article ddc:570 Hepatitis E virus -- zoo animals -- cross-species transmission -- Syrian brown bear (Ursus arctos syriacus) -- Norway rat (Rattus norvegicus) |
spellingShingle |
Text article ddc:570 Hepatitis E virus -- zoo animals -- cross-species transmission -- Syrian brown bear (Ursus arctos syriacus) -- Norway rat (Rattus norvegicus) Spahr, C. Ryll, René Knauf-Witzens, T. Vahlenkamp, T. W. Ulrich, Rainer Johne, Reimar Serological evidence of hepatitis E virus infection in zoo animals and identification of a rodent-borne strain in a Syrian brown bear |
topic_facet |
Text article ddc:570 Hepatitis E virus -- zoo animals -- cross-species transmission -- Syrian brown bear (Ursus arctos syriacus) -- Norway rat (Rattus norvegicus) |
description |
Hepatitis E virus (HEV) is the causative agent of hepatitis E, an emerging infectious disease of humans. HEV infections have also been described in various animal species. Whereas domestic pigs and wild boars are well-known animal reservoirs for HEV, the knowledge on natural HEV infection in zoo animals is scarce so far. Here, we analysed 244 sera from 66 mammal species derived from three zoos in Germany using a commercial double antigen sandwich ELISA. HEV-specific antibodies were detected in 16 animal species, with the highest detection rates in suids (33.3%) and carnivores (27.0%). However, RNA of the human pathogenic HEV genotypes 1 to 4 was not detected in the serum samples from suids or carnivores. Using a broad spectrum RT-PCR, a ratHEV-related sequence was identified in a sample of a female Syrian brown bear (Ursus arctos syriacus). Subsequent serum samples within a period of five years confirmed a HEV seroconversion in this animal. No symptoms of hepatitis were recorded. In a follow-up investigation at the same location, closely related ratHEV sequences were identified in free-living Norway rats (Rattus norvegicus), whereas feeder rats (Rattus norvegicus forma domestica) were negative for HEV-specific antibodies and RNA. Therefore, a spillover infection of ratHEV from free-living Norway rats is most likely. The results indicate that a wide range of zoo animals can be naturally infected with HEV or HEV-related viruses. Their distinct role as possible reservoir animals for HEV and sources of HEV infection for humans and other animals remains to be investigated. |
format |
Article in Journal/Newspaper |
author |
Spahr, C. Ryll, René Knauf-Witzens, T. Vahlenkamp, T. W. Ulrich, Rainer Johne, Reimar |
author_facet |
Spahr, C. Ryll, René Knauf-Witzens, T. Vahlenkamp, T. W. Ulrich, Rainer Johne, Reimar |
author_sort |
Spahr, C. |
title |
Serological evidence of hepatitis E virus infection in zoo animals and identification of a rodent-borne strain in a Syrian brown bear |
title_short |
Serological evidence of hepatitis E virus infection in zoo animals and identification of a rodent-borne strain in a Syrian brown bear |
title_full |
Serological evidence of hepatitis E virus infection in zoo animals and identification of a rodent-borne strain in a Syrian brown bear |
title_fullStr |
Serological evidence of hepatitis E virus infection in zoo animals and identification of a rodent-borne strain in a Syrian brown bear |
title_full_unstemmed |
Serological evidence of hepatitis E virus infection in zoo animals and identification of a rodent-borne strain in a Syrian brown bear |
title_sort |
serological evidence of hepatitis e virus infection in zoo animals and identification of a rodent-borne strain in a syrian brown bear |
publishDate |
2017 |
url |
https://doi.org/10.1016/j.vetmic.2017.11.005 https://www.openagrar.de/receive/openagrar_mods_00032193 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00007334/SD2017536.pdf https://www.sciencedirect.com/science/article/pii/S0378113517309768 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_relation |
Veterinary microbiology -- Vet. Microbiol. -- 1873-2542 -- 0378-1135 -- 1498996-7 -- 753154-0 -- http://www.sciencedirect.com/science/journal/03781135 -- http://www.bibliothek.uni-regensburg.de/ezeit/?1498996 https://doi.org/10.1016/j.vetmic.2017.11.005 https://www.openagrar.de/receive/openagrar_mods_00032193 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00007334/SD2017536.pdf https://www.sciencedirect.com/science/article/pii/S0378113517309768 |
op_rights |
only signed in user all rights reserved info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.vetmic.2017.11.005 |
container_title |
Veterinary Microbiology |
container_volume |
212 |
container_start_page |
87 |
op_container_end_page |
92 |
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1810484502030450688 |