Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus
Bokeloh bat lyssavirus (BBLV), a novel lyssavirus was isolated from a Natterer's bat (Myotis nattererii), a chiropteran species with a widespread and abundant distribution across Europe. As a novel lyssavirus, the risks of BBLV to animal and human health are unknown and as such characterization...
Published in: | Journal of General Virology |
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ftopenagrar:oai:www.openagrar.de:openagrar_mods_00003337 2024-09-15T18:19:06+00:00 Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus Nolden, Tobias Banyard, A.C. Finke, Stefan Fooks, A.R. Hanke, Dennis Höper, Dirk Horton, D. Mettenleiter, Thomas C. Müller, Thomas Teifke, Jens Peter Freuling, Conrad Martin 2014-05-14 https://doi.org/10.1099/vir.0.065953-0 https://www.openagrar.de/receive/openagrar_mods_00003337 https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00004572/SD2014194.pdf http://vir.sgmjournals.org/content/95/Pt_8/1647 eng eng Journal of General Virology -- J. Gen. Virol. -- JGV -- 0022-1317 -- 1465-2099 -- 219316-4 -- 2007065-2 -- http://jgv.microbiologyresearch.org/content/journal/jgv/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?2007065 https://doi.org/10.1099/vir.0.065953-0 https://www.openagrar.de/receive/openagrar_mods_00003337 https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00004572/SD2014194.pdf http://vir.sgmjournals.org/content/95/Pt_8/1647 public info:eu-repo/semantics/openAccess article Text ddc:570 article Text doc-type:article 2014 ftopenagrar https://doi.org/10.1099/vir.0.065953-0 2024-07-08T23:56:23Z Bokeloh bat lyssavirus (BBLV), a novel lyssavirus was isolated from a Natterer's bat (Myotis nattererii), a chiropteran species with a widespread and abundant distribution across Europe. As a novel lyssavirus, the risks of BBLV to animal and human health are unknown and as such characterization both in vitro and in vivo was required to assess pathogenicity and vaccine protection. Full genome sequence analysis and antigenic cartography demonstrated that the German BBLV isolates are most closely related to EBLV-2 and Khujand virus and can be characterised within phylogroup I. In vivocharacterization demonstrated that BBLV was pathogenic in mice when inoculated peripherally causing clinical signs typical for rabies encephalitis, with higher pathogenicity observed in juvenile mice. A limited vaccination challenge experiment in mice was conducted and suggested that current vaccines would afford some protection against BBLV although further studies are warranted to determine a serological cut off for protection. Article in Journal/Newspaper Natterer's bat OpenAgrar (OA) Journal of General Virology 95 8 1647 1653 |
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article Text ddc:570 |
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article Text ddc:570 Nolden, Tobias Banyard, A.C. Finke, Stefan Fooks, A.R. Hanke, Dennis Höper, Dirk Horton, D. Mettenleiter, Thomas C. Müller, Thomas Teifke, Jens Peter Freuling, Conrad Martin Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus |
topic_facet |
article Text ddc:570 |
description |
Bokeloh bat lyssavirus (BBLV), a novel lyssavirus was isolated from a Natterer's bat (Myotis nattererii), a chiropteran species with a widespread and abundant distribution across Europe. As a novel lyssavirus, the risks of BBLV to animal and human health are unknown and as such characterization both in vitro and in vivo was required to assess pathogenicity and vaccine protection. Full genome sequence analysis and antigenic cartography demonstrated that the German BBLV isolates are most closely related to EBLV-2 and Khujand virus and can be characterised within phylogroup I. In vivocharacterization demonstrated that BBLV was pathogenic in mice when inoculated peripherally causing clinical signs typical for rabies encephalitis, with higher pathogenicity observed in juvenile mice. A limited vaccination challenge experiment in mice was conducted and suggested that current vaccines would afford some protection against BBLV although further studies are warranted to determine a serological cut off for protection. |
format |
Article in Journal/Newspaper |
author |
Nolden, Tobias Banyard, A.C. Finke, Stefan Fooks, A.R. Hanke, Dennis Höper, Dirk Horton, D. Mettenleiter, Thomas C. Müller, Thomas Teifke, Jens Peter Freuling, Conrad Martin |
author_facet |
Nolden, Tobias Banyard, A.C. Finke, Stefan Fooks, A.R. Hanke, Dennis Höper, Dirk Horton, D. Mettenleiter, Thomas C. Müller, Thomas Teifke, Jens Peter Freuling, Conrad Martin |
author_sort |
Nolden, Tobias |
title |
Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus |
title_short |
Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus |
title_full |
Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus |
title_fullStr |
Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus |
title_full_unstemmed |
Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus |
title_sort |
comparative studies on the genetic, antigenic and pathogenic characteristics of bokeloh bat lyssavirus |
publishDate |
2014 |
url |
https://doi.org/10.1099/vir.0.065953-0 https://www.openagrar.de/receive/openagrar_mods_00003337 https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00004572/SD2014194.pdf http://vir.sgmjournals.org/content/95/Pt_8/1647 |
genre |
Natterer's bat |
genre_facet |
Natterer's bat |
op_relation |
Journal of General Virology -- J. Gen. Virol. -- JGV -- 0022-1317 -- 1465-2099 -- 219316-4 -- 2007065-2 -- http://jgv.microbiologyresearch.org/content/journal/jgv/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?2007065 https://doi.org/10.1099/vir.0.065953-0 https://www.openagrar.de/receive/openagrar_mods_00003337 https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00004572/SD2014194.pdf http://vir.sgmjournals.org/content/95/Pt_8/1647 |
op_rights |
public info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1099/vir.0.065953-0 |
container_title |
Journal of General Virology |
container_volume |
95 |
container_issue |
8 |
container_start_page |
1647 |
op_container_end_page |
1653 |
_version_ |
1810457202221121536 |