Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments
Rainbow trout and Atlantic salmon interleukin-4/13A (IL-4/13A) genes were identified. They were found expressed at high level in thymus, gill, and skin, in concert with the transcription factor gene GATA-3. High expression levels of IL-4, IL-13, and GATA-3 were also detected in murine thymus, sugges...
Published in: | Molecular Immunology |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2011
|
Subjects: | |
Online Access: | https://doi.org/10.1016/j.molimm.2011.02.014 https://www.openagrar.de/receive/fimport_mods_00000284 https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00000854/SD2011156.pdf |
id |
ftopenagrar:oai:www.openagrar.de:fimport_mods_00000284 |
---|---|
record_format |
openpolar |
spelling |
ftopenagrar:oai:www.openagrar.de:fimport_mods_00000284 2024-09-15T17:56:27+00:00 Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments Takizawa, Fumio Koppang, E.O. Ohtani, M. Nakanishi, T. Hashimoto, K. Fischer, Uwe Dijkstra, J.M. 2011 https://doi.org/10.1016/j.molimm.2011.02.014 https://www.openagrar.de/receive/fimport_mods_00000284 https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00000854/SD2011156.pdf eng eng Molecular immunology -- Mol. Immunol. -- 1872-9142 -- 0161-5890 -- 2013448-4 -- 424427-8 https://doi.org/10.1016/j.molimm.2011.02.014 https://www.openagrar.de/receive/fimport_mods_00000284 https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00000854/SD2011156.pdf only signed in user info:eu-repo/semantics/restrictedAccess article Text ddc:630 Interleukins 4 and 13 GATA-3 Thymus Gill Skin Fish article Text doc-type:article 2011 ftopenagrar https://doi.org/10.1016/j.molimm.2011.02.014 2024-07-08T23:56:23Z Rainbow trout and Atlantic salmon interleukin-4/13A (IL-4/13A) genes were identified. They were found expressed at high level in thymus, gill, and skin, in concert with the transcription factor gene GATA-3. High expression levels of IL-4, IL-13, and GATA-3 were also detected in murine thymus, suggesting similar importance of the fish and mammalian homologues for early T cell development. In mammals, combined high expression of IL-4/13 and GATA-3 in tissues other than thymus is mostly indicative of Th2 responses. Th2-skewage may protect fish skin and gill from parasites and from damage by inflammatory Th1 and Th17 responses. The immune milieus of fish gill and skin are relevant to aquaculture, because these tissues are preferred sites for vaccine administration. The similarities between the immune milieus of fish gill and thymus may reflect an evolutionary relationship, since these tissues map close together lining the gill cavity. Expression patterns of IL-4/13A and interferon gamma (IFN-?) in isolated trout gill cells and pronephrocytes were consistent with Th2 identity of IL-4/13A. Article in Journal/Newspaper Atlantic salmon OpenAgrar (OA) Molecular Immunology 48 12-13 1360 1368 |
institution |
Open Polar |
collection |
OpenAgrar (OA) |
op_collection_id |
ftopenagrar |
language |
English |
topic |
article Text ddc:630 Interleukins 4 and 13 GATA-3 Thymus Gill Skin Fish |
spellingShingle |
article Text ddc:630 Interleukins 4 and 13 GATA-3 Thymus Gill Skin Fish Takizawa, Fumio Koppang, E.O. Ohtani, M. Nakanishi, T. Hashimoto, K. Fischer, Uwe Dijkstra, J.M. Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments |
topic_facet |
article Text ddc:630 Interleukins 4 and 13 GATA-3 Thymus Gill Skin Fish |
description |
Rainbow trout and Atlantic salmon interleukin-4/13A (IL-4/13A) genes were identified. They were found expressed at high level in thymus, gill, and skin, in concert with the transcription factor gene GATA-3. High expression levels of IL-4, IL-13, and GATA-3 were also detected in murine thymus, suggesting similar importance of the fish and mammalian homologues for early T cell development. In mammals, combined high expression of IL-4/13 and GATA-3 in tissues other than thymus is mostly indicative of Th2 responses. Th2-skewage may protect fish skin and gill from parasites and from damage by inflammatory Th1 and Th17 responses. The immune milieus of fish gill and skin are relevant to aquaculture, because these tissues are preferred sites for vaccine administration. The similarities between the immune milieus of fish gill and thymus may reflect an evolutionary relationship, since these tissues map close together lining the gill cavity. Expression patterns of IL-4/13A and interferon gamma (IFN-?) in isolated trout gill cells and pronephrocytes were consistent with Th2 identity of IL-4/13A. |
format |
Article in Journal/Newspaper |
author |
Takizawa, Fumio Koppang, E.O. Ohtani, M. Nakanishi, T. Hashimoto, K. Fischer, Uwe Dijkstra, J.M. |
author_facet |
Takizawa, Fumio Koppang, E.O. Ohtani, M. Nakanishi, T. Hashimoto, K. Fischer, Uwe Dijkstra, J.M. |
author_sort |
Takizawa, Fumio |
title |
Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments |
title_short |
Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments |
title_full |
Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments |
title_fullStr |
Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments |
title_full_unstemmed |
Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments |
title_sort |
constitutive high expression of interleukin-4/13a and gata-3 in gill and skin of salmonid fishes suggests that these tissues form th2-skewed immune environments |
publishDate |
2011 |
url |
https://doi.org/10.1016/j.molimm.2011.02.014 https://www.openagrar.de/receive/fimport_mods_00000284 https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00000854/SD2011156.pdf |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
Molecular immunology -- Mol. Immunol. -- 1872-9142 -- 0161-5890 -- 2013448-4 -- 424427-8 https://doi.org/10.1016/j.molimm.2011.02.014 https://www.openagrar.de/receive/fimport_mods_00000284 https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00000854/SD2011156.pdf |
op_rights |
only signed in user info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.molimm.2011.02.014 |
container_title |
Molecular Immunology |
container_volume |
48 |
container_issue |
12-13 |
container_start_page |
1360 |
op_container_end_page |
1368 |
_version_ |
1810432655540355072 |