Angiotensin II-induced inotropism requires an endocardial endothelium-nitric oxide mechanism in the in-vitro heart of Anguilla anguilla

• Published in: Journal of Experimental Biology
• Main Authors: Imbrogno, Sandra, Cerra, Maria Carmela, Tota, Bruno
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2003
• Subjects: Insect Science; Molecular Biology; Animal Science and Zoology; Aquatic Science; Physiology; Ecology; Evolution; Behavior and Systematics; Triton; Anguilla anguilla
• Online Access: https://www.openaccessrepository.it/record/154814; https://doi.org/10.1242/jeb.00468

SUMMARY Using an isolated working heart preparation we show that angiotensin II(ANG II), at concentrations of 10-10–10-7 mol l-1, elicits negative chronotropism and inotropism in the freshwater eel Anguilla anguilla. The negative inotropism was insensitive to losartan and CGP42112 (AT1 and AT2 ANG...