Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny
Anterior/posterior (a/p) compression of the vertebral column, referred to as 'short tails', is a recurring event in farmed Atlantic salmon. Like other skeletal deformities, the problem usually becomes evident in a late life phase, too late for preventive measures, making it difficult to un...
Published in: | Diseases of Aquatic Organisms |
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Inter Research
2005
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Online Access: | https://oceanrep.geomar.de/id/eprint/5164/ https://oceanrep.geomar.de/id/eprint/5164/1/d064p237.pdf https://doi.org/10.3354/dao064237 |
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ftoceanrep:oai:oceanrep.geomar.de:5164 2023-05-15T15:32:05+02:00 Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny Witten, P. Eckhard Gil-Martens, L. Hall, B. K. Huysseune, A. Obach, A. 2005 text https://oceanrep.geomar.de/id/eprint/5164/ https://oceanrep.geomar.de/id/eprint/5164/1/d064p237.pdf https://doi.org/10.3354/dao064237 en eng Inter Research https://oceanrep.geomar.de/id/eprint/5164/1/d064p237.pdf Witten, P. E., Gil-Martens, L., Hall, B. K., Huysseune, A. and Obach, A. (2005) Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny. Diseases of Aquatic Organisms, 64 (3). pp. 237-246. DOI 10.3354/dao064237 <https://doi.org/10.3354/dao064237>. doi:10.3354/dao064237 cc_by_3.0 info:eu-repo/semantics/embargoedAccess Article PeerReviewed 2005 ftoceanrep https://doi.org/10.3354/dao064237 2023-04-07T14:50:36Z Anterior/posterior (a/p) compression of the vertebral column, referred to as 'short tails', is a recurring event in farmed Atlantic salmon. Like other skeletal deformities, the problem usually becomes evident in a late life phase, too late for preventive measures, making it difficult to understand the aetiology of the disease. We use structural, radiological, histological, and mineral analyses to study 'short tail' adult salmon and to demonstrate that the study of adult fish can provide important insights into earlier developmental processes. 'Short tails' display a/p compressed vertebrae throughout the spine, except for the first post-cranial vertebrae. The vertebral number is unaltered, but the intervertebral space is reduced and the vertebrae are shorter. Compressed vertebrae are characterized by an unchanged central part, altered vertebral end plates (straight instead of funnel-shaped), an atypical inward bending of the vertebral edges, and structural alterations in the intervertebral tissue. The spongiosa is unaffected. The growth zones of adjacent vertebrae fuse and blend towards the intervertebral space into chondrogenic tissue. This tissue produces different types of cartilage, replacing the notochord. The correspondence in location of intervertebral cartilage and deformed vertebral end plates, and the clearly delimited, unaltered, central vertebral parts suggest that the a/p compression of vertebral bodies is a late developmental disorder that may be related to a metaplastic shift of osteogenic tissue into chondrogenic tissue in the vertebral growth zone. Given the lack of evidence for infections, metabolic disorders and/or genetic disorders, we propose that an altered mechanical load could have caused the transformation of the bone growth zones and the concomitant replacement of the intervertebral (notochord) tissue by cartilaginous tissues in the 'short tails' studied here. This hypothesis is supported by the role that notochord cells are known to play in spine development and in maintaining the ... Article in Journal/Newspaper Atlantic salmon Salmo salar OceanRep (GEOMAR Helmholtz Centre für Ocean Research Kiel) Diseases of Aquatic Organisms 64 237 246 |
institution |
Open Polar |
collection |
OceanRep (GEOMAR Helmholtz Centre für Ocean Research Kiel) |
op_collection_id |
ftoceanrep |
language |
English |
description |
Anterior/posterior (a/p) compression of the vertebral column, referred to as 'short tails', is a recurring event in farmed Atlantic salmon. Like other skeletal deformities, the problem usually becomes evident in a late life phase, too late for preventive measures, making it difficult to understand the aetiology of the disease. We use structural, radiological, histological, and mineral analyses to study 'short tail' adult salmon and to demonstrate that the study of adult fish can provide important insights into earlier developmental processes. 'Short tails' display a/p compressed vertebrae throughout the spine, except for the first post-cranial vertebrae. The vertebral number is unaltered, but the intervertebral space is reduced and the vertebrae are shorter. Compressed vertebrae are characterized by an unchanged central part, altered vertebral end plates (straight instead of funnel-shaped), an atypical inward bending of the vertebral edges, and structural alterations in the intervertebral tissue. The spongiosa is unaffected. The growth zones of adjacent vertebrae fuse and blend towards the intervertebral space into chondrogenic tissue. This tissue produces different types of cartilage, replacing the notochord. The correspondence in location of intervertebral cartilage and deformed vertebral end plates, and the clearly delimited, unaltered, central vertebral parts suggest that the a/p compression of vertebral bodies is a late developmental disorder that may be related to a metaplastic shift of osteogenic tissue into chondrogenic tissue in the vertebral growth zone. Given the lack of evidence for infections, metabolic disorders and/or genetic disorders, we propose that an altered mechanical load could have caused the transformation of the bone growth zones and the concomitant replacement of the intervertebral (notochord) tissue by cartilaginous tissues in the 'short tails' studied here. This hypothesis is supported by the role that notochord cells are known to play in spine development and in maintaining the ... |
format |
Article in Journal/Newspaper |
author |
Witten, P. Eckhard Gil-Martens, L. Hall, B. K. Huysseune, A. Obach, A. |
spellingShingle |
Witten, P. Eckhard Gil-Martens, L. Hall, B. K. Huysseune, A. Obach, A. Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
author_facet |
Witten, P. Eckhard Gil-Martens, L. Hall, B. K. Huysseune, A. Obach, A. |
author_sort |
Witten, P. Eckhard |
title |
Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
title_short |
Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
title_full |
Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
title_fullStr |
Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
title_full_unstemmed |
Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
title_sort |
compressed vertebrae in atlantic salmon (salmo salar): evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny |
publisher |
Inter Research |
publishDate |
2005 |
url |
https://oceanrep.geomar.de/id/eprint/5164/ https://oceanrep.geomar.de/id/eprint/5164/1/d064p237.pdf https://doi.org/10.3354/dao064237 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
https://oceanrep.geomar.de/id/eprint/5164/1/d064p237.pdf Witten, P. E., Gil-Martens, L., Hall, B. K., Huysseune, A. and Obach, A. (2005) Compressed vertebrae in Atlantic salmon (Salmo salar): Evidence for metaplastic chondrogenesis as a skeletogenic response late in ontogeny. Diseases of Aquatic Organisms, 64 (3). pp. 237-246. DOI 10.3354/dao064237 <https://doi.org/10.3354/dao064237>. doi:10.3354/dao064237 |
op_rights |
cc_by_3.0 info:eu-repo/semantics/embargoedAccess |
op_doi |
https://doi.org/10.3354/dao064237 |
container_title |
Diseases of Aquatic Organisms |
container_volume |
64 |
container_start_page |
237 |
op_container_end_page |
246 |
_version_ |
1766362583700340736 |