Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp.
The combination of LC-MS/MS based metabolomics approach and anti-MRSA activity-guided fractionation scheme was applied on the Gram-negative bacterium Aequorivita sp. isolated from shallow Antarctic sea sediment using a miniaturized culture chip technique. This methodology afforded the isolation of t...
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Online Access: | https://oceanrep.geomar.de/id/eprint/43438/ https://oceanrep.geomar.de/id/eprint/43438/1/marinedrugs-16-00187-v3.pdf https://oceanrep.geomar.de/id/eprint/43438/2/marinedrugs-16-00187-s001.pdf https://doi.org/10.3390/md16060187 |
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ftoceanrep:oai:oceanrep.geomar.de:43438 2023-05-15T14:11:12+02:00 Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp. Chianese, Giuseppina Esposito, Fortunato Parrot, Delphine Ingham, Colin de Pascale, Donatella Tasdemir, Deniz 2018-05-28 text https://oceanrep.geomar.de/id/eprint/43438/ https://oceanrep.geomar.de/id/eprint/43438/1/marinedrugs-16-00187-v3.pdf https://oceanrep.geomar.de/id/eprint/43438/2/marinedrugs-16-00187-s001.pdf https://doi.org/10.3390/md16060187 en eng MDPI https://oceanrep.geomar.de/id/eprint/43438/1/marinedrugs-16-00187-v3.pdf https://oceanrep.geomar.de/id/eprint/43438/2/marinedrugs-16-00187-s001.pdf Chianese, G., Esposito, F., Parrot, D., Ingham, C., de Pascale, D. and Tasdemir, D. (2018) Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp. Open Access Marine Drugs, 16 (6, Article Nr. 187). DOI 10.3390/md16060187 <https://doi.org/10.3390/md16060187>. doi:10.3390/md16060187 cc_by_4.0 info:eu-repo/semantics/openAccess Article PeerReviewed 2018 ftoceanrep https://doi.org/10.3390/md16060187 2023-04-07T15:40:21Z The combination of LC-MS/MS based metabolomics approach and anti-MRSA activity-guided fractionation scheme was applied on the Gram-negative bacterium Aequorivita sp. isolated from shallow Antarctic sea sediment using a miniaturized culture chip technique. This methodology afforded the isolation of three new (1–3) and four known (4–7) N-terminal glycine- or serine-bearing iso-fatty acid amides esterified with another iso-fatty acid through their C-3 hydroxy groups. The chemical structures of the new compounds were elucidated using a set of spectroscopic (NMR, [α]D and FT-IR) and spectrometric (HRMS, HRMS/MS) methods. The aminolipids possessing an N-terminal glycine unit (1, 2, 4, 5) showed moderate in vitro antimicrobial activity against MRSA (IC50 values 22–145 µg/mL). This is the first in-depth chemistry and biological activity study performed on the microbial genus Aequorivita. Article in Journal/Newspaper Antarc* Antarctic OceanRep (GEOMAR Helmholtz Centre für Ocean Research Kiel) Antarctic The Antarctic Marine Drugs 16 6 187 |
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Open Polar |
collection |
OceanRep (GEOMAR Helmholtz Centre für Ocean Research Kiel) |
op_collection_id |
ftoceanrep |
language |
English |
description |
The combination of LC-MS/MS based metabolomics approach and anti-MRSA activity-guided fractionation scheme was applied on the Gram-negative bacterium Aequorivita sp. isolated from shallow Antarctic sea sediment using a miniaturized culture chip technique. This methodology afforded the isolation of three new (1–3) and four known (4–7) N-terminal glycine- or serine-bearing iso-fatty acid amides esterified with another iso-fatty acid through their C-3 hydroxy groups. The chemical structures of the new compounds were elucidated using a set of spectroscopic (NMR, [α]D and FT-IR) and spectrometric (HRMS, HRMS/MS) methods. The aminolipids possessing an N-terminal glycine unit (1, 2, 4, 5) showed moderate in vitro antimicrobial activity against MRSA (IC50 values 22–145 µg/mL). This is the first in-depth chemistry and biological activity study performed on the microbial genus Aequorivita. |
format |
Article in Journal/Newspaper |
author |
Chianese, Giuseppina Esposito, Fortunato Parrot, Delphine Ingham, Colin de Pascale, Donatella Tasdemir, Deniz |
spellingShingle |
Chianese, Giuseppina Esposito, Fortunato Parrot, Delphine Ingham, Colin de Pascale, Donatella Tasdemir, Deniz Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp. |
author_facet |
Chianese, Giuseppina Esposito, Fortunato Parrot, Delphine Ingham, Colin de Pascale, Donatella Tasdemir, Deniz |
author_sort |
Chianese, Giuseppina |
title |
Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp. |
title_short |
Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp. |
title_full |
Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp. |
title_fullStr |
Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp. |
title_full_unstemmed |
Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp. |
title_sort |
linear aminolipids with moderate antimicrobial activity from the antarctic gram-negative bacterium aequorivita sp. |
publisher |
MDPI |
publishDate |
2018 |
url |
https://oceanrep.geomar.de/id/eprint/43438/ https://oceanrep.geomar.de/id/eprint/43438/1/marinedrugs-16-00187-v3.pdf https://oceanrep.geomar.de/id/eprint/43438/2/marinedrugs-16-00187-s001.pdf https://doi.org/10.3390/md16060187 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
https://oceanrep.geomar.de/id/eprint/43438/1/marinedrugs-16-00187-v3.pdf https://oceanrep.geomar.de/id/eprint/43438/2/marinedrugs-16-00187-s001.pdf Chianese, G., Esposito, F., Parrot, D., Ingham, C., de Pascale, D. and Tasdemir, D. (2018) Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp. Open Access Marine Drugs, 16 (6, Article Nr. 187). DOI 10.3390/md16060187 <https://doi.org/10.3390/md16060187>. doi:10.3390/md16060187 |
op_rights |
cc_by_4.0 info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/md16060187 |
container_title |
Marine Drugs |
container_volume |
16 |
container_issue |
6 |
container_start_page |
187 |
_version_ |
1766283325356376064 |