Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106
Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as...
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Online Access: | https://oceanrep.geomar.de/id/eprint/24371/ https://oceanrep.geomar.de/id/eprint/24371/1/marinedrugs-12-01208.pdf https://doi.org/10.3390/md12031208 |
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ftoceanrep:oai:oceanrep.geomar.de:24371 2023-05-15T16:28:18+02:00 Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 Wu, Bin Oesker, Vanessa Wiese, Jutta Schmaljohann, Rolf Imhoff, Johannes F. 2014-03-06 text https://oceanrep.geomar.de/id/eprint/24371/ https://oceanrep.geomar.de/id/eprint/24371/1/marinedrugs-12-01208.pdf https://doi.org/10.3390/md12031208 en eng MDPI https://oceanrep.geomar.de/id/eprint/24371/1/marinedrugs-12-01208.pdf Wu, B., Oesker, V., Wiese, J. , Schmaljohann, R. and Imhoff, J. F. (2014) Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106. Open Access Marine Drugs, 12 (3). pp. 1208-1219. DOI 10.3390/md12031208 <https://doi.org/10.3390/md12031208>. doi:10.3390/md12031208 cc_by info:eu-repo/semantics/openAccess Article PeerReviewed 2014 ftoceanrep https://doi.org/10.3390/md12031208 2023-04-07T15:13:02Z Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively. Article in Journal/Newspaper Greenland OceanRep (GEOMAR Helmholtz Centre für Ocean Research Kiel) Greenland Marine Drugs 12 3 1208 1219 |
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Open Polar |
collection |
OceanRep (GEOMAR Helmholtz Centre für Ocean Research Kiel) |
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ftoceanrep |
language |
English |
description |
Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively. |
format |
Article in Journal/Newspaper |
author |
Wu, Bin Oesker, Vanessa Wiese, Jutta Schmaljohann, Rolf Imhoff, Johannes F. |
spellingShingle |
Wu, Bin Oesker, Vanessa Wiese, Jutta Schmaljohann, Rolf Imhoff, Johannes F. Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
author_facet |
Wu, Bin Oesker, Vanessa Wiese, Jutta Schmaljohann, Rolf Imhoff, Johannes F. |
author_sort |
Wu, Bin |
title |
Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
title_short |
Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
title_full |
Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
title_fullStr |
Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
title_full_unstemmed |
Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
title_sort |
two new antibiotic pyridones produced by a marine fungus, trichoderma sp. strain mf106 |
publisher |
MDPI |
publishDate |
2014 |
url |
https://oceanrep.geomar.de/id/eprint/24371/ https://oceanrep.geomar.de/id/eprint/24371/1/marinedrugs-12-01208.pdf https://doi.org/10.3390/md12031208 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_relation |
https://oceanrep.geomar.de/id/eprint/24371/1/marinedrugs-12-01208.pdf Wu, B., Oesker, V., Wiese, J. , Schmaljohann, R. and Imhoff, J. F. (2014) Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106. Open Access Marine Drugs, 12 (3). pp. 1208-1219. DOI 10.3390/md12031208 <https://doi.org/10.3390/md12031208>. doi:10.3390/md12031208 |
op_rights |
cc_by info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/md12031208 |
container_title |
Marine Drugs |
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12 |
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3 |
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1208 |
op_container_end_page |
1219 |
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1766017952937672704 |