Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study
Purpose Studies on patients suggest an association between anatomical variations in the Circle of Willis (CoW) and intracranial aneurysms (IA), but it is unclear whether this association is present in the general population. In this cross-sectional population study, we investigated the associations...
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ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/3088740 2023-10-09T21:56:18+02:00 Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study Hindenes, Lars Bakke Ingebrigtsen, Tor Isaksen, Jørgen Gjernes Håberg, Asta Johnsen, Liv-Hege Herder, Marit Mathiesen, Ellisiv B. Vangberg, Torgil Riise 2023 application/pdf https://hdl.handle.net/11250/3088740 https://doi.org/10.1016/j.jns.2023.120740 eng eng Journal of the Neurological Sciences. 2023, 452 . urn:issn:0022-510X https://hdl.handle.net/11250/3088740 https://doi.org/10.1016/j.jns.2023.120740 cristin:2170558 Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no 0 452 Journal of the Neurological Sciences Peer reviewed Journal article 2023 ftntnutrondheimi https://doi.org/10.1016/j.jns.2023.120740 2023-09-13T22:46:29Z Purpose Studies on patients suggest an association between anatomical variations in the Circle of Willis (CoW) and intracranial aneurysms (IA), but it is unclear whether this association is present in the general population. In this cross-sectional population study, we investigated the associations between CoW anatomical variations and IA. Methods We included 1667 participants from a population sample with 3 T MRI time-of-flight angiography (40–84 years, 46.5% men). Saccular IAs were defined as protrusions in the intracranial arteries ≥2 mm, while variants of the CoW were classified according to whether segments were missing or hypoplastic (< 1 mm). We used logistic regression, adjusting for age and IA risk factors, to assess whether participants with incomplete CoW variants had a greater prevalence of IA and whether participants with specific incomplete variants had a greater prevalence of IA. Results Participants with an incomplete CoW had an increased prevalence of IA (OR, 2.3 [95% CI 1.05–5.04]). This was mainly driven by the variant missing all three communicating arteries (OR, 4.2 [95% CI 1.7–1 0.3]) and the variant missing the P1 segment of the posterior cerebral artery (OR, 3.6 [95% CI 1.2–10.1]). The combined prevalence of the two variants was 15.4% but accounted for 28% of the IAs. Conclusion The findings suggest that an incomplete CoW is associated with an increased risk of IA for adults in the general population. publishedVersion Article in Journal/Newspaper Tromsø NTNU Open Archive (Norwegian University of Science and Technology) Tromsø Willis ENVELOPE(159.450,159.450,-79.367,-79.367) Journal of the Neurological Sciences 452 120740 |
institution |
Open Polar |
collection |
NTNU Open Archive (Norwegian University of Science and Technology) |
op_collection_id |
ftntnutrondheimi |
language |
English |
description |
Purpose Studies on patients suggest an association between anatomical variations in the Circle of Willis (CoW) and intracranial aneurysms (IA), but it is unclear whether this association is present in the general population. In this cross-sectional population study, we investigated the associations between CoW anatomical variations and IA. Methods We included 1667 participants from a population sample with 3 T MRI time-of-flight angiography (40–84 years, 46.5% men). Saccular IAs were defined as protrusions in the intracranial arteries ≥2 mm, while variants of the CoW were classified according to whether segments were missing or hypoplastic (< 1 mm). We used logistic regression, adjusting for age and IA risk factors, to assess whether participants with incomplete CoW variants had a greater prevalence of IA and whether participants with specific incomplete variants had a greater prevalence of IA. Results Participants with an incomplete CoW had an increased prevalence of IA (OR, 2.3 [95% CI 1.05–5.04]). This was mainly driven by the variant missing all three communicating arteries (OR, 4.2 [95% CI 1.7–1 0.3]) and the variant missing the P1 segment of the posterior cerebral artery (OR, 3.6 [95% CI 1.2–10.1]). The combined prevalence of the two variants was 15.4% but accounted for 28% of the IAs. Conclusion The findings suggest that an incomplete CoW is associated with an increased risk of IA for adults in the general population. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Hindenes, Lars Bakke Ingebrigtsen, Tor Isaksen, Jørgen Gjernes Håberg, Asta Johnsen, Liv-Hege Herder, Marit Mathiesen, Ellisiv B. Vangberg, Torgil Riise |
spellingShingle |
Hindenes, Lars Bakke Ingebrigtsen, Tor Isaksen, Jørgen Gjernes Håberg, Asta Johnsen, Liv-Hege Herder, Marit Mathiesen, Ellisiv B. Vangberg, Torgil Riise Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study |
author_facet |
Hindenes, Lars Bakke Ingebrigtsen, Tor Isaksen, Jørgen Gjernes Håberg, Asta Johnsen, Liv-Hege Herder, Marit Mathiesen, Ellisiv B. Vangberg, Torgil Riise |
author_sort |
Hindenes, Lars Bakke |
title |
Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study |
title_short |
Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study |
title_full |
Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study |
title_fullStr |
Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study |
title_full_unstemmed |
Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study |
title_sort |
anatomical variations in the circle of willis are associated with increased odds of intracranial aneurysms: the tromsø study |
publishDate |
2023 |
url |
https://hdl.handle.net/11250/3088740 https://doi.org/10.1016/j.jns.2023.120740 |
long_lat |
ENVELOPE(159.450,159.450,-79.367,-79.367) |
geographic |
Tromsø Willis |
geographic_facet |
Tromsø Willis |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
0 452 Journal of the Neurological Sciences |
op_relation |
Journal of the Neurological Sciences. 2023, 452 . urn:issn:0022-510X https://hdl.handle.net/11250/3088740 https://doi.org/10.1016/j.jns.2023.120740 cristin:2170558 |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no |
op_doi |
https://doi.org/10.1016/j.jns.2023.120740 |
container_title |
Journal of the Neurological Sciences |
container_volume |
452 |
container_start_page |
120740 |
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1779320929491353600 |