Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels A Randomized Clinical Trial
Importance Topical vitamin D analogues are routine treatment for psoriasis, but the effect of oral supplementation has not been established. Objective To examine the effect of vitamin D supplementation on psoriasis severity throughout the winter. Design, Setting, and Participants This randomized, do...
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American Medical Association
2023
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Online Access: | https://hdl.handle.net/11250/3061468 https://doi.org/10.1001/jamadermatol.2023.0357 |
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ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/3061468 2023-05-15T17:39:25+02:00 Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels A Randomized Clinical Trial Jenssen, Marita Furberg, Anne-Sofie Jorde, Rolf Wilsgaard, Tom Danielsen, Kjersti 2023 application/pdf https://hdl.handle.net/11250/3061468 https://doi.org/10.1001/jamadermatol.2023.0357 eng eng American Medical Association urn:issn:2168-6068 https://hdl.handle.net/11250/3061468 https://doi.org/10.1001/jamadermatol.2023.0357 cristin:2138373 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no JAMA dermatology Peer reviewed Journal article 2023 ftntnutrondheimi https://doi.org/10.1001/jamadermatol.2023.0357 2023-04-05T22:44:30Z Importance Topical vitamin D analogues are routine treatment for psoriasis, but the effect of oral supplementation has not been established. Objective To examine the effect of vitamin D supplementation on psoriasis severity throughout the winter. Design, Setting, and Participants This randomized, double-blind placebo-controlled clinical trial with 2 parallel groups was performed through 2 winter seasons (2017 to 2018 and 2018 to 2019). Randomization was computer generated. All participants, health care clinicians, and outcome assessors were masked to group assignment. Each participant was followed for 4 months. The presented analyses were conducted in May 2022. The trial was conducted at the clinical research unit of the University Hospital of North Norway (Tromsø; Norway). Adults from the general population in Tromsø with active plaque psoriasis and 25-hydroxyvitamin D (25[OH]D) levels of less than 24 ng/mL (to convert to nmol/L, multiply by 2.496) were included. Intervention Vitamin D (cholecalciferol, 100 000 IU, loading dose, followed by 20 000 IU/week) or placebo for 4 months. Main outcomes and Measures Psoriasis Area Severity Index (PASI) (primary outcome), Physician Global Assessment, self-administered PASI, and Dermatology Life Quality Index scores (secondary outcomes). Results A total of 122 participants (46 women [37.7%]; mean [SD] age, 53.6 [10.0] years; mean [SD] PASI score, 3.1 [2.0]; mean [SD] serum 25(OH)D, 14.9 [3.9] ng/mL) were included. Of these, 60 (49.2%) were randomized to the vitamin D group and 62 (50.8%) to the placebo group. A total of 120 participants (59 vitamin D [49.2%]/61 placebo [51.8%]) completed the study. By completion, mean (SD) 25(OH)D levels were 29.7 (5.2) ng/mL (vitamin D) and 12.0 (3.8) ng/mL (placebo). There was no significant difference in change in PASI score between the groups (adjusted difference, 0.11; 95% CI, −0.23 to 0.45). There was no significant difference in change in Physician Global Assessment score (adjusted odds ratio, 0.66; 95% CI, 0.27-1.63), ... Article in Journal/Newspaper North Norway Tromsø NTNU Open Archive (Norwegian University of Science and Technology) Norway Tromsø JAMA Dermatology |
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Open Polar |
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NTNU Open Archive (Norwegian University of Science and Technology) |
op_collection_id |
ftntnutrondheimi |
language |
English |
description |
Importance Topical vitamin D analogues are routine treatment for psoriasis, but the effect of oral supplementation has not been established. Objective To examine the effect of vitamin D supplementation on psoriasis severity throughout the winter. Design, Setting, and Participants This randomized, double-blind placebo-controlled clinical trial with 2 parallel groups was performed through 2 winter seasons (2017 to 2018 and 2018 to 2019). Randomization was computer generated. All participants, health care clinicians, and outcome assessors were masked to group assignment. Each participant was followed for 4 months. The presented analyses were conducted in May 2022. The trial was conducted at the clinical research unit of the University Hospital of North Norway (Tromsø; Norway). Adults from the general population in Tromsø with active plaque psoriasis and 25-hydroxyvitamin D (25[OH]D) levels of less than 24 ng/mL (to convert to nmol/L, multiply by 2.496) were included. Intervention Vitamin D (cholecalciferol, 100 000 IU, loading dose, followed by 20 000 IU/week) or placebo for 4 months. Main outcomes and Measures Psoriasis Area Severity Index (PASI) (primary outcome), Physician Global Assessment, self-administered PASI, and Dermatology Life Quality Index scores (secondary outcomes). Results A total of 122 participants (46 women [37.7%]; mean [SD] age, 53.6 [10.0] years; mean [SD] PASI score, 3.1 [2.0]; mean [SD] serum 25(OH)D, 14.9 [3.9] ng/mL) were included. Of these, 60 (49.2%) were randomized to the vitamin D group and 62 (50.8%) to the placebo group. A total of 120 participants (59 vitamin D [49.2%]/61 placebo [51.8%]) completed the study. By completion, mean (SD) 25(OH)D levels were 29.7 (5.2) ng/mL (vitamin D) and 12.0 (3.8) ng/mL (placebo). There was no significant difference in change in PASI score between the groups (adjusted difference, 0.11; 95% CI, −0.23 to 0.45). There was no significant difference in change in Physician Global Assessment score (adjusted odds ratio, 0.66; 95% CI, 0.27-1.63), ... |
format |
Article in Journal/Newspaper |
author |
Jenssen, Marita Furberg, Anne-Sofie Jorde, Rolf Wilsgaard, Tom Danielsen, Kjersti |
spellingShingle |
Jenssen, Marita Furberg, Anne-Sofie Jorde, Rolf Wilsgaard, Tom Danielsen, Kjersti Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels A Randomized Clinical Trial |
author_facet |
Jenssen, Marita Furberg, Anne-Sofie Jorde, Rolf Wilsgaard, Tom Danielsen, Kjersti |
author_sort |
Jenssen, Marita |
title |
Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels A Randomized Clinical Trial |
title_short |
Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels A Randomized Clinical Trial |
title_full |
Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels A Randomized Clinical Trial |
title_fullStr |
Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels A Randomized Clinical Trial |
title_full_unstemmed |
Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels A Randomized Clinical Trial |
title_sort |
effect of vitamin d supplementation on psoriasis severity in patients with lower-range serum 25-hydroxyvitamin d levels a randomized clinical trial |
publisher |
American Medical Association |
publishDate |
2023 |
url |
https://hdl.handle.net/11250/3061468 https://doi.org/10.1001/jamadermatol.2023.0357 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
North Norway Tromsø |
genre_facet |
North Norway Tromsø |
op_source |
JAMA dermatology |
op_relation |
urn:issn:2168-6068 https://hdl.handle.net/11250/3061468 https://doi.org/10.1001/jamadermatol.2023.0357 cristin:2138373 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no |
op_doi |
https://doi.org/10.1001/jamadermatol.2023.0357 |
container_title |
JAMA Dermatology |
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1766140188462940160 |