Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients
Background There is evidence that brain-derived neurotropic factor (BDNF) plays a protective role in the brain. Peripheral levels of BDNF correlate with its concentration in the brain. Previous studies have revealed lower serum BDNF levels in patients with mental illnesses. In most studies serum BDN...
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ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/3042106 2023-05-15T17:24:42+02:00 Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients Soløy-Nilsen, Hedda Nygård-Odeh, Kristin Kristiansen, Magnhild Gangsøy Brekke, Ole Lars Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Øiesvold, Terje 2022 application/pdf https://hdl.handle.net/11250/3042106 https://doi.org/10.1186/s12888-022-03744-2 eng eng BMC BMC Psychiatry. 2022, 22 (1), . urn:issn:1471-244X https://hdl.handle.net/11250/3042106 https://doi.org/10.1186/s12888-022-03744-2 cristin:2018812 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no CC-BY 0 22 BMC Psychiatry 1 Peer reviewed Journal article 2022 ftntnutrondheimi https://doi.org/10.1186/s12888-022-03744-2 2023-01-11T23:42:57Z Background There is evidence that brain-derived neurotropic factor (BDNF) plays a protective role in the brain. Peripheral levels of BDNF correlate with its concentration in the brain. Previous studies have revealed lower serum BDNF levels in patients with mental illnesses. In most studies serum BDNF correlates negatively with psychiatric disorders and disease severity. Most studies in this field are on psychiatric diagnosis and personality traits. The aim of our study is to explore associations between general psychiatric symptoms, independent of diagnostic groups, and serum BDNF as well as the inflammatory biomarker high-sensitive CRP (hs-CRP). Comparison between the group regularly using psychotropic medication and those not using psychotropic medication is conducted. Methods The study is a cross sectional study with 132 participants from a general open inpatient psychiatric ward at the Nordland Hospital Trust, Bodoe, Norway. Participants were assessed on serum levels of BDNF and hs-CRP. Psychiatric symptoms were assessed by a self-rating scale (Symptom check list, SCL-90- R). Multiple linear regression model was used for statistical analyses of associations between levels of BDNF, hs-CRP and symptoms. Results We found a positive association (p < 0.05), for most SCL-90 symptom clusters with BDNF in the psychotropic medication-free group. No associations were found in the group of patients using psychotropic medication, except one, the paranoid ideation cluster (p 0.022). No associations were found between hs-CRP and symptom clusters. Conclusion We found no relation between symptom clusters and the inflammatory biomarker hs-CRP. Serum BDNF levels were positively associated with intensity of psychiatric symptoms in the group of patients not using psychotropic medication. Our findings are in conflict with several previous studies reporting increased hs-CRP as well as decreased rather than increased BDNF in mental suffering. Patients on psychotropic medication may not require the same upregulation because the ... Article in Journal/Newspaper Nordland Nordland Nordland NTNU Open Archive (Norwegian University of Science and Technology) Norway BMC Psychiatry 22 1 |
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Open Polar |
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NTNU Open Archive (Norwegian University of Science and Technology) |
op_collection_id |
ftntnutrondheimi |
language |
English |
description |
Background There is evidence that brain-derived neurotropic factor (BDNF) plays a protective role in the brain. Peripheral levels of BDNF correlate with its concentration in the brain. Previous studies have revealed lower serum BDNF levels in patients with mental illnesses. In most studies serum BDNF correlates negatively with psychiatric disorders and disease severity. Most studies in this field are on psychiatric diagnosis and personality traits. The aim of our study is to explore associations between general psychiatric symptoms, independent of diagnostic groups, and serum BDNF as well as the inflammatory biomarker high-sensitive CRP (hs-CRP). Comparison between the group regularly using psychotropic medication and those not using psychotropic medication is conducted. Methods The study is a cross sectional study with 132 participants from a general open inpatient psychiatric ward at the Nordland Hospital Trust, Bodoe, Norway. Participants were assessed on serum levels of BDNF and hs-CRP. Psychiatric symptoms were assessed by a self-rating scale (Symptom check list, SCL-90- R). Multiple linear regression model was used for statistical analyses of associations between levels of BDNF, hs-CRP and symptoms. Results We found a positive association (p < 0.05), for most SCL-90 symptom clusters with BDNF in the psychotropic medication-free group. No associations were found in the group of patients using psychotropic medication, except one, the paranoid ideation cluster (p 0.022). No associations were found between hs-CRP and symptom clusters. Conclusion We found no relation between symptom clusters and the inflammatory biomarker hs-CRP. Serum BDNF levels were positively associated with intensity of psychiatric symptoms in the group of patients not using psychotropic medication. Our findings are in conflict with several previous studies reporting increased hs-CRP as well as decreased rather than increased BDNF in mental suffering. Patients on psychotropic medication may not require the same upregulation because the ... |
format |
Article in Journal/Newspaper |
author |
Soløy-Nilsen, Hedda Nygård-Odeh, Kristin Kristiansen, Magnhild Gangsøy Brekke, Ole Lars Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Øiesvold, Terje |
spellingShingle |
Soløy-Nilsen, Hedda Nygård-Odeh, Kristin Kristiansen, Magnhild Gangsøy Brekke, Ole Lars Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Øiesvold, Terje Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
author_facet |
Soløy-Nilsen, Hedda Nygård-Odeh, Kristin Kristiansen, Magnhild Gangsøy Brekke, Ole Lars Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Øiesvold, Terje |
author_sort |
Soløy-Nilsen, Hedda |
title |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_short |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_full |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_fullStr |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_full_unstemmed |
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients |
title_sort |
association between brain-derived neurotropic factor (bdnf), high-sensitivity c-reactive protein (hs-crp) and psychiatric symptoms in medicated and unmedicated patients |
publisher |
BMC |
publishDate |
2022 |
url |
https://hdl.handle.net/11250/3042106 https://doi.org/10.1186/s12888-022-03744-2 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Nordland Nordland Nordland |
genre_facet |
Nordland Nordland Nordland |
op_source |
0 22 BMC Psychiatry 1 |
op_relation |
BMC Psychiatry. 2022, 22 (1), . urn:issn:1471-244X https://hdl.handle.net/11250/3042106 https://doi.org/10.1186/s12888-022-03744-2 cristin:2018812 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s12888-022-03744-2 |
container_title |
BMC Psychiatry |
container_volume |
22 |
container_issue |
1 |
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1766115809110786048 |