Molecular Regulation of Biosynthesis of Long Chain Polyunsaturated Fatty Acids in Atlantic Salmon
Salmon is a rich source of health-promoting omega-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA), such as eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3). The LC-PUFA biosynthetic pathway in Atlantic salmon is one of the most studied compared to other teleosts. T...
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ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/3031901 2023-05-15T15:30:46+02:00 Molecular Regulation of Biosynthesis of Long Chain Polyunsaturated Fatty Acids in Atlantic Salmon Datsomor, Alex Kojo Gillard, Gareth Benjamin Jin, Yang Olsen, Rolf Erik Sandve, Simen Rød 2022 application/pdf https://hdl.handle.net/11250/3031901 https://doi.org/10.1007/s10126-022-10144-w eng eng Springer Nature Norges forskningsråd: 248792 Norges forskningsråd: 244164 Norges forskningsråd: 274669 Marine Biotechnology. 2022, 24 (4), 661-670. urn:issn:1436-2228 https://hdl.handle.net/11250/3031901 https://doi.org/10.1007/s10126-022-10144-w cristin:2042101 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no CC-BY 661-670 24 Marine Biotechnology 4 Peer reviewed Journal article 2022 ftntnutrondheimi https://doi.org/10.1007/s10126-022-10144-w 2022-11-16T23:42:02Z Salmon is a rich source of health-promoting omega-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA), such as eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3). The LC-PUFA biosynthetic pathway in Atlantic salmon is one of the most studied compared to other teleosts. This has largely been due to the massive replacement of LC-PUFA-rich ingredients in aquafeeds with terrestrial plant oils devoid of these essential fatty acids (EFA) which ultimately pushed dietary content towards the minimal requirement of EFA. The practice would also reduce tissue content of n-3 LC-PUFA compromising the nutritional value of salmon to the human consumer. These necessitated detailed studies of endogenous biosynthetic capability as a contributor to these EFA. This review seeks to provide a comprehensive and concise overview of the current knowledge about the molecular genetics of PUFA biosynthesis in Atlantic salmon, highlighting the enzymology and nutritional regulation as well as transcriptional control networks. Furthermore, we discuss the impact of genome duplication on the complexity of salmon LC-PUFA pathway and highlight probable implications on endogenous biosynthetic capabilities. Finally, we have also compiled and made available a large RNAseq dataset from 316 salmon liver samples together with an R-script visualization resource to aid in explorative and hypothesis-driven research into salmon lipid metabolism. publishedVersion Article in Journal/Newspaper Atlantic salmon NTNU Open Archive (Norwegian University of Science and Technology) Marine Biotechnology 24 4 661 670 |
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Open Polar |
collection |
NTNU Open Archive (Norwegian University of Science and Technology) |
op_collection_id |
ftntnutrondheimi |
language |
English |
description |
Salmon is a rich source of health-promoting omega-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA), such as eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3). The LC-PUFA biosynthetic pathway in Atlantic salmon is one of the most studied compared to other teleosts. This has largely been due to the massive replacement of LC-PUFA-rich ingredients in aquafeeds with terrestrial plant oils devoid of these essential fatty acids (EFA) which ultimately pushed dietary content towards the minimal requirement of EFA. The practice would also reduce tissue content of n-3 LC-PUFA compromising the nutritional value of salmon to the human consumer. These necessitated detailed studies of endogenous biosynthetic capability as a contributor to these EFA. This review seeks to provide a comprehensive and concise overview of the current knowledge about the molecular genetics of PUFA biosynthesis in Atlantic salmon, highlighting the enzymology and nutritional regulation as well as transcriptional control networks. Furthermore, we discuss the impact of genome duplication on the complexity of salmon LC-PUFA pathway and highlight probable implications on endogenous biosynthetic capabilities. Finally, we have also compiled and made available a large RNAseq dataset from 316 salmon liver samples together with an R-script visualization resource to aid in explorative and hypothesis-driven research into salmon lipid metabolism. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Datsomor, Alex Kojo Gillard, Gareth Benjamin Jin, Yang Olsen, Rolf Erik Sandve, Simen Rød |
spellingShingle |
Datsomor, Alex Kojo Gillard, Gareth Benjamin Jin, Yang Olsen, Rolf Erik Sandve, Simen Rød Molecular Regulation of Biosynthesis of Long Chain Polyunsaturated Fatty Acids in Atlantic Salmon |
author_facet |
Datsomor, Alex Kojo Gillard, Gareth Benjamin Jin, Yang Olsen, Rolf Erik Sandve, Simen Rød |
author_sort |
Datsomor, Alex Kojo |
title |
Molecular Regulation of Biosynthesis of Long Chain Polyunsaturated Fatty Acids in Atlantic Salmon |
title_short |
Molecular Regulation of Biosynthesis of Long Chain Polyunsaturated Fatty Acids in Atlantic Salmon |
title_full |
Molecular Regulation of Biosynthesis of Long Chain Polyunsaturated Fatty Acids in Atlantic Salmon |
title_fullStr |
Molecular Regulation of Biosynthesis of Long Chain Polyunsaturated Fatty Acids in Atlantic Salmon |
title_full_unstemmed |
Molecular Regulation of Biosynthesis of Long Chain Polyunsaturated Fatty Acids in Atlantic Salmon |
title_sort |
molecular regulation of biosynthesis of long chain polyunsaturated fatty acids in atlantic salmon |
publisher |
Springer Nature |
publishDate |
2022 |
url |
https://hdl.handle.net/11250/3031901 https://doi.org/10.1007/s10126-022-10144-w |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
661-670 24 Marine Biotechnology 4 |
op_relation |
Norges forskningsråd: 248792 Norges forskningsråd: 244164 Norges forskningsråd: 274669 Marine Biotechnology. 2022, 24 (4), 661-670. urn:issn:1436-2228 https://hdl.handle.net/11250/3031901 https://doi.org/10.1007/s10126-022-10144-w cristin:2042101 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s10126-022-10144-w |
container_title |
Marine Biotechnology |
container_volume |
24 |
container_issue |
4 |
container_start_page |
661 |
op_container_end_page |
670 |
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1766361221326438400 |