Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway
Objectives Transcatheter aortic valve implantation (TAVI)-specific risk scores have been developed based on large registry studies. Our aim was to evaluate how both surgical and novel TAVI risk scores performed in predicting all cause 30-day mortality. In addition, we wanted to explore the validity...
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ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/2976716 2023-05-15T17:39:23+02:00 Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway Kjønås, Didrik Dahle, Gro Schirmer, Henrik Malm, Siri Eidet, Jo Aaberge, Lars Steigen, Terje Aakhus, Svend Busund, Rolf Røsner, Assami 2021 application/pdf https://hdl.handle.net/11250/2976716 https://doi.org/10.1002/hsr2.283 eng eng Wiley Open Access urn:issn:2398-8835 https://hdl.handle.net/11250/2976716 https://doi.org/10.1002/hsr2.283 cristin:1967667 Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no CC-BY-NC-ND 4 Health Science Reports Journal article Peer reviewed 2021 ftntnutrondheimi https://doi.org/10.1002/hsr2.283 2022-02-09T23:38:20Z Objectives Transcatheter aortic valve implantation (TAVI)-specific risk scores have been developed based on large registry studies. Our aim was to evaluate how both surgical and novel TAVI risk scores performed in predicting all cause 30-day mortality. In addition, we wanted to explore the validity of our own previously developed model in a separate and more recent cohort. Methods The derivation cohort included patients not eligible for open surgery treated with TAVI at the University Hospital of North Norway (UNN) and Oslo University Hospital (OUS) from February 2010 through June 2013. From this cohort, a logistic prediction model (UNN/OUS) for all cause 30-day mortality was developed. The validation cohort consisted of patients not included in the derivation cohort and treated with TAVI at UNN between June 2010 and April 2017. EuroSCORE, Logistic EuroSCORE, EurosSCORE 2, STS score, German AV score, OBSERVANT score, IRRMA score, and FRANCE-2 score were calculated for both cohorts. The discriminative accuracy of each score, including our model, was evaluated by receiver operating characteristic (ROC) analysis and compared using DeLong test where P< .05 was considered statistically significant. Results The derivation cohort consisted of 218 and the validation cohort of 241 patients. Our model showed statistically significant better accuracy than all other scores in the derivation cohort. In the validation cohort, the FRANCE-2 had a significantly higher predictive accuracy compared to all scores except the IRRMA and STS score. Our model showed similar results. Conclusion Existing risk scores have shown limited accuracy in predicting early mortality after TAVI. Our results indicate that TAVI-specific risk scores might be useful when evaluating patients for TAVI. publishedVersion Article in Journal/Newspaper North Norway NTNU Open Archive (Norwegian University of Science and Technology) Norway Health Science Reports 4 2 |
institution |
Open Polar |
collection |
NTNU Open Archive (Norwegian University of Science and Technology) |
op_collection_id |
ftntnutrondheimi |
language |
English |
description |
Objectives Transcatheter aortic valve implantation (TAVI)-specific risk scores have been developed based on large registry studies. Our aim was to evaluate how both surgical and novel TAVI risk scores performed in predicting all cause 30-day mortality. In addition, we wanted to explore the validity of our own previously developed model in a separate and more recent cohort. Methods The derivation cohort included patients not eligible for open surgery treated with TAVI at the University Hospital of North Norway (UNN) and Oslo University Hospital (OUS) from February 2010 through June 2013. From this cohort, a logistic prediction model (UNN/OUS) for all cause 30-day mortality was developed. The validation cohort consisted of patients not included in the derivation cohort and treated with TAVI at UNN between June 2010 and April 2017. EuroSCORE, Logistic EuroSCORE, EurosSCORE 2, STS score, German AV score, OBSERVANT score, IRRMA score, and FRANCE-2 score were calculated for both cohorts. The discriminative accuracy of each score, including our model, was evaluated by receiver operating characteristic (ROC) analysis and compared using DeLong test where P< .05 was considered statistically significant. Results The derivation cohort consisted of 218 and the validation cohort of 241 patients. Our model showed statistically significant better accuracy than all other scores in the derivation cohort. In the validation cohort, the FRANCE-2 had a significantly higher predictive accuracy compared to all scores except the IRRMA and STS score. Our model showed similar results. Conclusion Existing risk scores have shown limited accuracy in predicting early mortality after TAVI. Our results indicate that TAVI-specific risk scores might be useful when evaluating patients for TAVI. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Kjønås, Didrik Dahle, Gro Schirmer, Henrik Malm, Siri Eidet, Jo Aaberge, Lars Steigen, Terje Aakhus, Svend Busund, Rolf Røsner, Assami |
spellingShingle |
Kjønås, Didrik Dahle, Gro Schirmer, Henrik Malm, Siri Eidet, Jo Aaberge, Lars Steigen, Terje Aakhus, Svend Busund, Rolf Røsner, Assami Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway |
author_facet |
Kjønås, Didrik Dahle, Gro Schirmer, Henrik Malm, Siri Eidet, Jo Aaberge, Lars Steigen, Terje Aakhus, Svend Busund, Rolf Røsner, Assami |
author_sort |
Kjønås, Didrik |
title |
Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway |
title_short |
Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway |
title_full |
Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway |
title_fullStr |
Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway |
title_full_unstemmed |
Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway |
title_sort |
risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: results from a two-center study in norway |
publisher |
Wiley Open Access |
publishDate |
2021 |
url |
https://hdl.handle.net/11250/2976716 https://doi.org/10.1002/hsr2.283 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
North Norway |
genre_facet |
North Norway |
op_source |
4 Health Science Reports |
op_relation |
urn:issn:2398-8835 https://hdl.handle.net/11250/2976716 https://doi.org/10.1002/hsr2.283 cristin:1967667 |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1002/hsr2.283 |
container_title |
Health Science Reports |
container_volume |
4 |
container_issue |
2 |
_version_ |
1766140152513560576 |