Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study
The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibits considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of...
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ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/2727630 2023-05-15T18:34:44+02:00 Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study Hindenes, Lars Bakke Håberg, Asta Johnsen, Liv-Hege Mathiesen, Ellisiv B. David, Robben Vangberg, Torgil Riise 2020 application/pdf https://hdl.handle.net/11250/2727630 https://doi.org/10.1371/journal.pone.0241373 eng eng Public Library of Science Helse Nord RHF: SFP1271- 16 Helse Nord RHF: HNF1369-17 urn:issn:1932-6203 https://hdl.handle.net/11250/2727630 https://doi.org/10.1371/journal.pone.0241373 cristin:1860179 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no CC-BY PLOS ONE Peer reviewed Journal article 2020 ftntnutrondheimi https://doi.org/10.1371/journal.pone.0241373 2021-02-17T23:34:37Z The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibits considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of CoW variants in a community-dwelling sample (N = 1,864, 874 men, mean age = 65.4, range 40–87 years), and independent and conditional frequencies of the CoW’s artery segments. CoW segments were classified as present or missing/hypoplastic (w/1mm diameter threshold) on 3T time-of-flight magnetic resonance angiography images. We also examined whether age and sex were associated with CoW variants. We identified 47 unique CoW variants, of which five variants constituted 68.5% of the sample. The complete variant was found in 11.9% of the subjects, and the most common variant (27.8%) was missing both posterior communicating arteries. Conditional frequencies showed patterns of interdependence across most missing segments in the CoW. CoW variants were associated with mean-split age (P = .0147), and there was a trend showing more missing segments with increasing age. We found no association with sex (P = .0526). Our population study demonstrated age as associated with CoW variants, suggesting reduced collateral capacity with older age. publishedVersion © 2020 Hindenes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Article in Journal/Newspaper Tromsø NTNU Open Archive (Norwegian University of Science and Technology) Tromsø Willis ENVELOPE(159.450,159.450,-79.367,-79.367) PLOS ONE 15 11 e0241373 |
institution |
Open Polar |
collection |
NTNU Open Archive (Norwegian University of Science and Technology) |
op_collection_id |
ftntnutrondheimi |
language |
English |
description |
The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibits considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of CoW variants in a community-dwelling sample (N = 1,864, 874 men, mean age = 65.4, range 40–87 years), and independent and conditional frequencies of the CoW’s artery segments. CoW segments were classified as present or missing/hypoplastic (w/1mm diameter threshold) on 3T time-of-flight magnetic resonance angiography images. We also examined whether age and sex were associated with CoW variants. We identified 47 unique CoW variants, of which five variants constituted 68.5% of the sample. The complete variant was found in 11.9% of the subjects, and the most common variant (27.8%) was missing both posterior communicating arteries. Conditional frequencies showed patterns of interdependence across most missing segments in the CoW. CoW variants were associated with mean-split age (P = .0147), and there was a trend showing more missing segments with increasing age. We found no association with sex (P = .0526). Our population study demonstrated age as associated with CoW variants, suggesting reduced collateral capacity with older age. publishedVersion © 2020 Hindenes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
format |
Article in Journal/Newspaper |
author |
Hindenes, Lars Bakke Håberg, Asta Johnsen, Liv-Hege Mathiesen, Ellisiv B. David, Robben Vangberg, Torgil Riise |
spellingShingle |
Hindenes, Lars Bakke Håberg, Asta Johnsen, Liv-Hege Mathiesen, Ellisiv B. David, Robben Vangberg, Torgil Riise Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
author_facet |
Hindenes, Lars Bakke Håberg, Asta Johnsen, Liv-Hege Mathiesen, Ellisiv B. David, Robben Vangberg, Torgil Riise |
author_sort |
Hindenes, Lars Bakke |
title |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
title_short |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
title_full |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
title_fullStr |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
title_full_unstemmed |
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study |
title_sort |
variations in the circle of willis in a large population sample using 3d tof angiography: the tromsø study |
publisher |
Public Library of Science |
publishDate |
2020 |
url |
https://hdl.handle.net/11250/2727630 https://doi.org/10.1371/journal.pone.0241373 |
long_lat |
ENVELOPE(159.450,159.450,-79.367,-79.367) |
geographic |
Tromsø Willis |
geographic_facet |
Tromsø Willis |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
PLOS ONE |
op_relation |
Helse Nord RHF: SFP1271- 16 Helse Nord RHF: HNF1369-17 urn:issn:1932-6203 https://hdl.handle.net/11250/2727630 https://doi.org/10.1371/journal.pone.0241373 cristin:1860179 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0241373 |
container_title |
PLOS ONE |
container_volume |
15 |
container_issue |
11 |
container_start_page |
e0241373 |
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1766219618889760768 |