The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study
Study Objectives To examine independent associations of sleeplessness and high-sensitivity C-reactive protein (hsCRP) with risk of chronic musculoskeletal pain, and to explore the joint effect of sleeplessness and hsCRP on risk of chronic musculoskeletal pain. Methods A population-based prospective...
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Oxford Universoty Press
2019
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Online Access: | http://hdl.handle.net/11250/2635816 https://doi.org/10.1093/sleep/zsz127 |
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ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/2635816 2023-05-15T18:34:53+02:00 The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study Skarpsno, Eivind S. Mork, Paul Jarle Nilsen, Tom Ivar Lund Steingrímsdóttir, Ólöf Anna Zwart, John Anker Nilsen, Kristian Bernhard 2019 http://hdl.handle.net/11250/2635816 https://doi.org/10.1093/sleep/zsz127 eng eng Oxford Universoty Press Sleep. 2019, 42 (9), . urn:issn:0161-8105 http://hdl.handle.net/11250/2635816 https://doi.org/10.1093/sleep/zsz127 cristin:1712889 8 42 Sleep 9 Journal article Peer reviewed 2019 ftntnutrondheimi https://doi.org/10.1093/sleep/zsz127 2020-01-15T23:32:27Z Study Objectives To examine independent associations of sleeplessness and high-sensitivity C-reactive protein (hsCRP) with risk of chronic musculoskeletal pain, and to explore the joint effect of sleeplessness and hsCRP on risk of chronic musculoskeletal pain. Methods A population-based prospective study of 3214 women and 3142 men (mean age: 55.4, range: 32–87) without severe chronic musculoskeletal pain and with hsCRP ≤ 10 mg/L at baseline in 2007–2008. Modified Poisson regression was used to calculate adjusted risk ratios (RRs) with 95% confidence intervals (CIs) for any chronic musculoskeletal pain and chronic widespread pain (CWP) at follow-up in 2015–2016 associated with self-reported sleeplessness and hsCRP at baseline. Results Compared with persons without sleeplessness, women and men reporting often/or always sleeplessness had RRs of CWP of 2.53 (95% CI: 1.94–3.29) and 2.48 (95% CI: 1.63–3.77), respectively. There was no clear association between hsCRP and risk of any chronic musculoskeletal pain or CWP. Joint effect analyses using persons without sleeplessness and with a hsCRP < 1.00 mg/L as the reference gave RRs for chronic musculoskeletal pain of 1.73 (95% CI: 1.26–2.37) for those with often/always sleeplessness and hsCRP < 1.00 mg/L; 1.01 (95% CI: 0.78–1.32) for those without sleeplessness and hsCRP ≥3.00 mg/L; and 2.47 (95% CI: 1.79–3.40) if they had both often/always sleeplessness and hsCRP ≥ 3.00 mg/L. The corresponding RRs for CWP were 1.89 (95% CI: 1.27–2.83), 0.96 (95% CI: 0.68–1.37), and 2.83 (95% CI: 1.91–4.20), respectively. Conclusions These results suggest that there is an interplay between sleeplessness and hsCRP on risk of any chronic musculoskeletal pain and CWP. acceptedVersion This is a pre-copyedited, author-produced version of an article accepted for publication in Sleep following peer review. The version of record is available online at: [10.1093/sleep/zsz127]. Article in Journal/Newspaper Tromsø NTNU Open Archive (Norwegian University of Science and Technology) Tromsø Sleep 42 9 |
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Open Polar |
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NTNU Open Archive (Norwegian University of Science and Technology) |
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ftntnutrondheimi |
language |
English |
description |
Study Objectives To examine independent associations of sleeplessness and high-sensitivity C-reactive protein (hsCRP) with risk of chronic musculoskeletal pain, and to explore the joint effect of sleeplessness and hsCRP on risk of chronic musculoskeletal pain. Methods A population-based prospective study of 3214 women and 3142 men (mean age: 55.4, range: 32–87) without severe chronic musculoskeletal pain and with hsCRP ≤ 10 mg/L at baseline in 2007–2008. Modified Poisson regression was used to calculate adjusted risk ratios (RRs) with 95% confidence intervals (CIs) for any chronic musculoskeletal pain and chronic widespread pain (CWP) at follow-up in 2015–2016 associated with self-reported sleeplessness and hsCRP at baseline. Results Compared with persons without sleeplessness, women and men reporting often/or always sleeplessness had RRs of CWP of 2.53 (95% CI: 1.94–3.29) and 2.48 (95% CI: 1.63–3.77), respectively. There was no clear association between hsCRP and risk of any chronic musculoskeletal pain or CWP. Joint effect analyses using persons without sleeplessness and with a hsCRP < 1.00 mg/L as the reference gave RRs for chronic musculoskeletal pain of 1.73 (95% CI: 1.26–2.37) for those with often/always sleeplessness and hsCRP < 1.00 mg/L; 1.01 (95% CI: 0.78–1.32) for those without sleeplessness and hsCRP ≥3.00 mg/L; and 2.47 (95% CI: 1.79–3.40) if they had both often/always sleeplessness and hsCRP ≥ 3.00 mg/L. The corresponding RRs for CWP were 1.89 (95% CI: 1.27–2.83), 0.96 (95% CI: 0.68–1.37), and 2.83 (95% CI: 1.91–4.20), respectively. Conclusions These results suggest that there is an interplay between sleeplessness and hsCRP on risk of any chronic musculoskeletal pain and CWP. acceptedVersion This is a pre-copyedited, author-produced version of an article accepted for publication in Sleep following peer review. The version of record is available online at: [10.1093/sleep/zsz127]. |
format |
Article in Journal/Newspaper |
author |
Skarpsno, Eivind S. Mork, Paul Jarle Nilsen, Tom Ivar Lund Steingrímsdóttir, Ólöf Anna Zwart, John Anker Nilsen, Kristian Bernhard |
spellingShingle |
Skarpsno, Eivind S. Mork, Paul Jarle Nilsen, Tom Ivar Lund Steingrímsdóttir, Ólöf Anna Zwart, John Anker Nilsen, Kristian Bernhard The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
author_facet |
Skarpsno, Eivind S. Mork, Paul Jarle Nilsen, Tom Ivar Lund Steingrímsdóttir, Ólöf Anna Zwart, John Anker Nilsen, Kristian Bernhard |
author_sort |
Skarpsno, Eivind S. |
title |
The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
title_short |
The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
title_full |
The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
title_fullStr |
The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
title_full_unstemmed |
The interplay between sleeplessness and high-sensitivity C-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the Tromsø Study |
title_sort |
interplay between sleeplessness and high-sensitivity c-reactive protein on risk of chronic musculoskeletal pain: longitudinal data from the tromsø study |
publisher |
Oxford Universoty Press |
publishDate |
2019 |
url |
http://hdl.handle.net/11250/2635816 https://doi.org/10.1093/sleep/zsz127 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
8 42 Sleep 9 |
op_relation |
Sleep. 2019, 42 (9), . urn:issn:0161-8105 http://hdl.handle.net/11250/2635816 https://doi.org/10.1093/sleep/zsz127 cristin:1712889 |
op_doi |
https://doi.org/10.1093/sleep/zsz127 |
container_title |
Sleep |
container_volume |
42 |
container_issue |
9 |
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1766219852452724736 |