Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex
The rat hippocampal formation (HF), parahippocampal region (PHR), and retrosplenial cortex (RSC) play critical roles in spatial processing. These regions are interconnected, and functionally dependent. The neuronal networks mediating this reciprocal dependency are largely unknown. Establishing the d...
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Online Access: | http://hdl.handle.net/11250/2624037 https://doi.org/10.1111/ejn.14395 |
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ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/2624037 2023-05-15T14:25:30+02:00 Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex Haugland, Kamilla Gjerland Sugar, Jørgen Witter, Menno 2019 http://hdl.handle.net/11250/2624037 https://doi.org/10.1111/ejn.14395 eng eng Wiley Norges forskningsråd: Centre for Neural Computation 223262 Norges forskningsråd: NORBRAIN 1 197467 Universitetet i Tromsø: The Arctic University of Norway 227769 European Journal of Neuroscience. 2019, 1-21. urn:issn:0953-816X http://hdl.handle.net/11250/2624037 https://doi.org/10.1111/ejn.14395 cristin:1702583 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no CC-BY 1-21 European Journal of Neuroscience Journal article Peer reviewed 2019 ftntnutrondheimi https://doi.org/10.1111/ejn.14395 2019-11-01T12:24:05Z The rat hippocampal formation (HF), parahippocampal region (PHR), and retrosplenial cortex (RSC) play critical roles in spatial processing. These regions are interconnected, and functionally dependent. The neuronal networks mediating this reciprocal dependency are largely unknown. Establishing the developmental timing of network formation will help to understand the emergence of this dependency. We questioned whether the long‐range outputs from HF‐PHR to RSC in Long Evans rats develop during the same time periods as previously reported for the intrinsic HF‐PHR connectivity and the projections from RSC to HF‐PHR. The results of a series of retrograde and anterograde tracing experiments in rats of different postnatal ages show that the postnatal projections from HF‐PHR to RSC display low densities around birth, but develop during the first postnatal week, reaching adult‐like densities around the time of eye‐opening. Developing projections display a topographical organization similar to adult projections. We conclude that the long‐range projections from HF‐PHR to RSC develop in parallel with the intrinsic circuitry of HF‐PHR and the projections of RSC to HF‐PHR. publishedVersion © 2019 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License Article in Journal/Newspaper Arctic NTNU Open Archive (Norwegian University of Science and Technology) European Journal of Neuroscience 50 1 1799 1819 |
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Open Polar |
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NTNU Open Archive (Norwegian University of Science and Technology) |
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ftntnutrondheimi |
language |
English |
description |
The rat hippocampal formation (HF), parahippocampal region (PHR), and retrosplenial cortex (RSC) play critical roles in spatial processing. These regions are interconnected, and functionally dependent. The neuronal networks mediating this reciprocal dependency are largely unknown. Establishing the developmental timing of network formation will help to understand the emergence of this dependency. We questioned whether the long‐range outputs from HF‐PHR to RSC in Long Evans rats develop during the same time periods as previously reported for the intrinsic HF‐PHR connectivity and the projections from RSC to HF‐PHR. The results of a series of retrograde and anterograde tracing experiments in rats of different postnatal ages show that the postnatal projections from HF‐PHR to RSC display low densities around birth, but develop during the first postnatal week, reaching adult‐like densities around the time of eye‐opening. Developing projections display a topographical organization similar to adult projections. We conclude that the long‐range projections from HF‐PHR to RSC develop in parallel with the intrinsic circuitry of HF‐PHR and the projections of RSC to HF‐PHR. publishedVersion © 2019 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License |
format |
Article in Journal/Newspaper |
author |
Haugland, Kamilla Gjerland Sugar, Jørgen Witter, Menno |
spellingShingle |
Haugland, Kamilla Gjerland Sugar, Jørgen Witter, Menno Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex |
author_facet |
Haugland, Kamilla Gjerland Sugar, Jørgen Witter, Menno |
author_sort |
Haugland, Kamilla Gjerland |
title |
Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex |
title_short |
Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex |
title_full |
Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex |
title_fullStr |
Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex |
title_full_unstemmed |
Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex |
title_sort |
development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex |
publisher |
Wiley |
publishDate |
2019 |
url |
http://hdl.handle.net/11250/2624037 https://doi.org/10.1111/ejn.14395 |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
1-21 European Journal of Neuroscience |
op_relation |
Norges forskningsråd: Centre for Neural Computation 223262 Norges forskningsråd: NORBRAIN 1 197467 Universitetet i Tromsø: The Arctic University of Norway 227769 European Journal of Neuroscience. 2019, 1-21. urn:issn:0953-816X http://hdl.handle.net/11250/2624037 https://doi.org/10.1111/ejn.14395 cristin:1702583 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1111/ejn.14395 |
container_title |
European Journal of Neuroscience |
container_volume |
50 |
container_issue |
1 |
container_start_page |
1799 |
op_container_end_page |
1819 |
_version_ |
1766297883216183296 |