Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: A double-blind cross-over trial
The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these conditions. Several studies have shown a protein preload before a meal to be...
Published in: | Journal of Nutritional Science |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Cambridge University Press (CUP)
2018
|
Subjects: | |
Online Access: | http://hdl.handle.net/11250/2593662 https://doi.org/10.1017/jns.2018.23 |
id |
ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/2593662 |
---|---|
record_format |
openpolar |
spelling |
ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/2593662 2023-05-15T15:27:51+02:00 Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: A double-blind cross-over trial Dale, Hanna Fjeldheim Jensen, Caroline Hausken, Trygve Lied, Einar Hatlebakk, Jan Gunnar Brønstad, Ingeborg Hoff, Dag Arne Lihaug Lied, Gülen Arslan 2018 http://hdl.handle.net/11250/2593662 https://doi.org/10.1017/jns.2018.23 eng eng Cambridge University Press (CUP) Journal of Nutritional Science. 2018, 7 . urn:issn:2048-6790 http://hdl.handle.net/11250/2593662 https://doi.org/10.1017/jns.2018.23 cristin:1637341 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no CC-BY 9 7 Journal of Nutritional Science Journal article Peer reviewed 2018 ftntnutrondheimi https://doi.org/10.1017/jns.2018.23 2019-09-17T06:54:49Z The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these conditions. Several studies have shown a protein preload before a meal to be effective in lowering the postprandial glycaemic response in healthy individuals and patients with T2DM. The aim of the present study was to assess the effect of a marine protein hydrolysate (MPH) from Atlantic cod (Gadus morhua) on postprandial glucose metabolism in healthy, middle-aged to elderly subjects. This double-blind cross-over trial (n 41) included two study days with 4–7 d wash-out in between. The intervention consisted of 20 mg of MPH (or casein as control) per kg body weight given before a breakfast meal. The primary outcome was postprandial response in glucose metabolism, measured by samples of serum glucose, insulin and plasma glucagon-like peptide 1 (GLP-1) in 20 min intervals for 180 min. In a mixed-model regression analysis, no differences were observed between MPH and control for postprandial glucose concentration (mean difference: −0·04 (95 % CI –0·17, 0·09) mmol/l; P = 0·573) or GLP-1 concentration (mean difference between geometric means: 1·02 (95 % CI 0·99, 1·06) pmol/l; P = 0·250). The postprandial insulin concentration was significantly lower after MPH compared with control (mean difference between geometric means: 1·067 (95 % CI 1·01, 1·13) mIU/l; P = 0·032). Our findings demonstrate that a single dose of MPH before a breakfast meal reduces postprandial insulin secretion, without affecting blood glucose response or GLP-1 levels, in healthy individuals. Further studies with repeated dosing and in target groups with abnormal glucose control are warranted. publishedVersion This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Article in Journal/Newspaper atlantic cod Gadus morhua NTNU Open Archive (Norwegian University of Science and Technology) Journal of Nutritional Science 7 |
institution |
Open Polar |
collection |
NTNU Open Archive (Norwegian University of Science and Technology) |
op_collection_id |
ftntnutrondheimi |
language |
English |
description |
The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these conditions. Several studies have shown a protein preload before a meal to be effective in lowering the postprandial glycaemic response in healthy individuals and patients with T2DM. The aim of the present study was to assess the effect of a marine protein hydrolysate (MPH) from Atlantic cod (Gadus morhua) on postprandial glucose metabolism in healthy, middle-aged to elderly subjects. This double-blind cross-over trial (n 41) included two study days with 4–7 d wash-out in between. The intervention consisted of 20 mg of MPH (or casein as control) per kg body weight given before a breakfast meal. The primary outcome was postprandial response in glucose metabolism, measured by samples of serum glucose, insulin and plasma glucagon-like peptide 1 (GLP-1) in 20 min intervals for 180 min. In a mixed-model regression analysis, no differences were observed between MPH and control for postprandial glucose concentration (mean difference: −0·04 (95 % CI –0·17, 0·09) mmol/l; P = 0·573) or GLP-1 concentration (mean difference between geometric means: 1·02 (95 % CI 0·99, 1·06) pmol/l; P = 0·250). The postprandial insulin concentration was significantly lower after MPH compared with control (mean difference between geometric means: 1·067 (95 % CI 1·01, 1·13) mIU/l; P = 0·032). Our findings demonstrate that a single dose of MPH before a breakfast meal reduces postprandial insulin secretion, without affecting blood glucose response or GLP-1 levels, in healthy individuals. Further studies with repeated dosing and in target groups with abnormal glucose control are warranted. publishedVersion This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
format |
Article in Journal/Newspaper |
author |
Dale, Hanna Fjeldheim Jensen, Caroline Hausken, Trygve Lied, Einar Hatlebakk, Jan Gunnar Brønstad, Ingeborg Hoff, Dag Arne Lihaug Lied, Gülen Arslan |
spellingShingle |
Dale, Hanna Fjeldheim Jensen, Caroline Hausken, Trygve Lied, Einar Hatlebakk, Jan Gunnar Brønstad, Ingeborg Hoff, Dag Arne Lihaug Lied, Gülen Arslan Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: A double-blind cross-over trial |
author_facet |
Dale, Hanna Fjeldheim Jensen, Caroline Hausken, Trygve Lied, Einar Hatlebakk, Jan Gunnar Brønstad, Ingeborg Hoff, Dag Arne Lihaug Lied, Gülen Arslan |
author_sort |
Dale, Hanna Fjeldheim |
title |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: A double-blind cross-over trial |
title_short |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: A double-blind cross-over trial |
title_full |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: A double-blind cross-over trial |
title_fullStr |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: A double-blind cross-over trial |
title_full_unstemmed |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: A double-blind cross-over trial |
title_sort |
effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
publisher |
Cambridge University Press (CUP) |
publishDate |
2018 |
url |
http://hdl.handle.net/11250/2593662 https://doi.org/10.1017/jns.2018.23 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
9 7 Journal of Nutritional Science |
op_relation |
Journal of Nutritional Science. 2018, 7 . urn:issn:2048-6790 http://hdl.handle.net/11250/2593662 https://doi.org/10.1017/jns.2018.23 cristin:1637341 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1017/jns.2018.23 |
container_title |
Journal of Nutritional Science |
container_volume |
7 |
_version_ |
1766358256428515328 |