Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for seasonal feeders. We set out to study whether organohalogenated compounds (OHCs) c...
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ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/2468494 2023-05-15T15:17:52+02:00 Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears Tartu, Sabrina Lille-Langøy, Roger Størseth, Trond Røvik Bourgeon, Sophie Brunsvik, Anders Goksøyr, Anders Jenssen, Bjørn Munro Polder, Anuschka Thiemann, Gregory W. Torget, Vidar Routti, Heli 2017 http://hdl.handle.net/11250/2468494 https://doi.org/10.1038/s41598-017-16820-5 eng eng Nature Publishing Group Scientific Reports. 2017, 7: 16487 urn:issn:2045-2322 http://hdl.handle.net/11250/2468494 https://doi.org/10.1038/s41598-017-16820-5 cristin:1519516 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no CC-BY 7 Scientific Reports Journal article Peer reviewed 2017 ftntnutrondheimi https://doi.org/10.1038/s41598-017-16820-5 2019-09-17T06:53:14Z There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for seasonal feeders. We set out to study whether organohalogenated compounds (OHCs) could cause disruption of energy metabolism in female polar bears (Ursus maritimus) from Svalbard, Norway (n=112). We analyzed biomarkers of energy metabolism including the abundance profles of nine lipid-related genes, fatty acid (FA) synthesis and elongation indices in adipose tissue, and concentrations of lipid-related variables in plasma (cholesterol, high-density lipoprotein, triglycerides). Furthermore, the plasma metabolome and lipidome were characterized by low molecular weight metabolites and lipid fngerprinting, respectively. Polychlorinated biphenyls, chlordanes, brominated diphenyl ethers and perfuoroalkyl substances were signifcantly related to biomarkers involved in lipid accumulation, FA metabolism, insulin utilization, and cholesterol homeostasis. Moreover, the efects of pollutants were measurable at the metabolome and lipidome levels. Our results indicate that several OHCs afect lipid biosynthesis and catabolism in female polar bears. Furthermore, these efects were more pronounced when combined with reduced sea ice extent and thickness, suggesting that climatedriven sea ice decline and OHCs have synergistic negative efects on polar bears. publishedVersion © The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Article in Journal/Newspaper Arctic Sea ice Svalbard Ursus maritimus NTNU Open Archive (Norwegian University of Science and Technology) Arctic Norway Svalbard Scientific Reports 7 1 |
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NTNU Open Archive (Norwegian University of Science and Technology) |
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ftntnutrondheimi |
language |
English |
description |
There is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for seasonal feeders. We set out to study whether organohalogenated compounds (OHCs) could cause disruption of energy metabolism in female polar bears (Ursus maritimus) from Svalbard, Norway (n=112). We analyzed biomarkers of energy metabolism including the abundance profles of nine lipid-related genes, fatty acid (FA) synthesis and elongation indices in adipose tissue, and concentrations of lipid-related variables in plasma (cholesterol, high-density lipoprotein, triglycerides). Furthermore, the plasma metabolome and lipidome were characterized by low molecular weight metabolites and lipid fngerprinting, respectively. Polychlorinated biphenyls, chlordanes, brominated diphenyl ethers and perfuoroalkyl substances were signifcantly related to biomarkers involved in lipid accumulation, FA metabolism, insulin utilization, and cholesterol homeostasis. Moreover, the efects of pollutants were measurable at the metabolome and lipidome levels. Our results indicate that several OHCs afect lipid biosynthesis and catabolism in female polar bears. Furthermore, these efects were more pronounced when combined with reduced sea ice extent and thickness, suggesting that climatedriven sea ice decline and OHCs have synergistic negative efects on polar bears. publishedVersion © The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
format |
Article in Journal/Newspaper |
author |
Tartu, Sabrina Lille-Langøy, Roger Størseth, Trond Røvik Bourgeon, Sophie Brunsvik, Anders Goksøyr, Anders Jenssen, Bjørn Munro Polder, Anuschka Thiemann, Gregory W. Torget, Vidar Routti, Heli |
spellingShingle |
Tartu, Sabrina Lille-Langøy, Roger Størseth, Trond Røvik Bourgeon, Sophie Brunsvik, Anders Goksøyr, Anders Jenssen, Bjørn Munro Polder, Anuschka Thiemann, Gregory W. Torget, Vidar Routti, Heli Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
author_facet |
Tartu, Sabrina Lille-Langøy, Roger Størseth, Trond Røvik Bourgeon, Sophie Brunsvik, Anders Goksøyr, Anders Jenssen, Bjørn Munro Polder, Anuschka Thiemann, Gregory W. Torget, Vidar Routti, Heli |
author_sort |
Tartu, Sabrina |
title |
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
title_short |
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
title_full |
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
title_fullStr |
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
title_full_unstemmed |
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
title_sort |
multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears |
publisher |
Nature Publishing Group |
publishDate |
2017 |
url |
http://hdl.handle.net/11250/2468494 https://doi.org/10.1038/s41598-017-16820-5 |
geographic |
Arctic Norway Svalbard |
geographic_facet |
Arctic Norway Svalbard |
genre |
Arctic Sea ice Svalbard Ursus maritimus |
genre_facet |
Arctic Sea ice Svalbard Ursus maritimus |
op_source |
7 Scientific Reports |
op_relation |
Scientific Reports. 2017, 7: 16487 urn:issn:2045-2322 http://hdl.handle.net/11250/2468494 https://doi.org/10.1038/s41598-017-16820-5 cristin:1519516 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-017-16820-5 |
container_title |
Scientific Reports |
container_volume |
7 |
container_issue |
1 |
_version_ |
1766348117348712448 |