Dissimilar effects of organohalogenated compounds on thyroid hormones in glaucous gulls
The glaucous gull (Larus hyperboreus) is an arctic top predator and scavenger exposed to high levels of mixtures of organohalogenated contaminants (OHCs) of which many interfere with the thyroid hormone (TH) system. In the present study, we applied statistical modeling to investigate the potential c...
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Online Access: | http://hdl.handle.net/11250/2457519 https://doi.org/10.1016/j.envres.2017.06.007 |
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ftntnutrondheimi:oai:ntnuopen.ntnu.no:11250/2457519 2023-05-15T15:08:34+02:00 Dissimilar effects of organohalogenated compounds on thyroid hormones in glaucous gulls Melnes, Marte Gabrielsen, Geir W Herzke, Dorte Sagerup, Kjetil Jenssen, Bjørn Munro 2017 http://hdl.handle.net/11250/2457519 https://doi.org/10.1016/j.envres.2017.06.007 eng eng Elsevier Environmental Research. 2017, 158 350-357. urn:issn:0013-9351 http://hdl.handle.net/11250/2457519 https://doi.org/10.1016/j.envres.2017.06.007 cristin:1493658 Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no CC-BY-NC-ND 350-357 158 Environmental Research Journal article Peer reviewed 2017 ftntnutrondheimi https://doi.org/10.1016/j.envres.2017.06.007 2019-09-17T06:52:53Z The glaucous gull (Larus hyperboreus) is an arctic top predator and scavenger exposed to high levels of mixtures of organohalogenated contaminants (OHCs) of which many interfere with the thyroid hormone (TH) system. In the present study, we applied statistical modeling to investigate the potential combined influence of the mixture of chlorinated, brominated and perfluorinated organic compounds in plasma of glaucous gulls on their plasma TH concentrations. In females, there were significant negative associations between several organochlorinated compounds (OCs) and free thyroxin (FT4) and triiodothyronine (FT3), indicating additive negative effects on FT4 and FT3. However, in these females there was also a significant positive association between perfluorooctane sulfonate (PFOS) and FT3. The inverse associations between several OCs and FT3 and the contrasting positive association between PFOS and FT3, indicate that these two groups of OHCs may have dissimilar and antagonistic effects on FT3 in female glaucous gulls. In males, there were no associations between any of the OHCs and the THs. That OHCs affect THs in a complex manner involving both additive and antagonistic effects add to the challenge of interpreting the overall functional effect of thyroid disruptive chemicals in wildlife. However, experimental studies are needed to confirm or disprove such effects. acceptedVersion This is the authors' accepted and refereed manuscript to the article. Locked until 03 July 2019 due to copyright restrictions Article in Journal/Newspaper Arctic Glaucous Gull Larus hyperboreus NTNU Open Archive (Norwegian University of Science and Technology) Arctic Environmental Research 158 350 357 |
institution |
Open Polar |
collection |
NTNU Open Archive (Norwegian University of Science and Technology) |
op_collection_id |
ftntnutrondheimi |
language |
English |
description |
The glaucous gull (Larus hyperboreus) is an arctic top predator and scavenger exposed to high levels of mixtures of organohalogenated contaminants (OHCs) of which many interfere with the thyroid hormone (TH) system. In the present study, we applied statistical modeling to investigate the potential combined influence of the mixture of chlorinated, brominated and perfluorinated organic compounds in plasma of glaucous gulls on their plasma TH concentrations. In females, there were significant negative associations between several organochlorinated compounds (OCs) and free thyroxin (FT4) and triiodothyronine (FT3), indicating additive negative effects on FT4 and FT3. However, in these females there was also a significant positive association between perfluorooctane sulfonate (PFOS) and FT3. The inverse associations between several OCs and FT3 and the contrasting positive association between PFOS and FT3, indicate that these two groups of OHCs may have dissimilar and antagonistic effects on FT3 in female glaucous gulls. In males, there were no associations between any of the OHCs and the THs. That OHCs affect THs in a complex manner involving both additive and antagonistic effects add to the challenge of interpreting the overall functional effect of thyroid disruptive chemicals in wildlife. However, experimental studies are needed to confirm or disprove such effects. acceptedVersion This is the authors' accepted and refereed manuscript to the article. Locked until 03 July 2019 due to copyright restrictions |
format |
Article in Journal/Newspaper |
author |
Melnes, Marte Gabrielsen, Geir W Herzke, Dorte Sagerup, Kjetil Jenssen, Bjørn Munro |
spellingShingle |
Melnes, Marte Gabrielsen, Geir W Herzke, Dorte Sagerup, Kjetil Jenssen, Bjørn Munro Dissimilar effects of organohalogenated compounds on thyroid hormones in glaucous gulls |
author_facet |
Melnes, Marte Gabrielsen, Geir W Herzke, Dorte Sagerup, Kjetil Jenssen, Bjørn Munro |
author_sort |
Melnes, Marte |
title |
Dissimilar effects of organohalogenated compounds on thyroid hormones in glaucous gulls |
title_short |
Dissimilar effects of organohalogenated compounds on thyroid hormones in glaucous gulls |
title_full |
Dissimilar effects of organohalogenated compounds on thyroid hormones in glaucous gulls |
title_fullStr |
Dissimilar effects of organohalogenated compounds on thyroid hormones in glaucous gulls |
title_full_unstemmed |
Dissimilar effects of organohalogenated compounds on thyroid hormones in glaucous gulls |
title_sort |
dissimilar effects of organohalogenated compounds on thyroid hormones in glaucous gulls |
publisher |
Elsevier |
publishDate |
2017 |
url |
http://hdl.handle.net/11250/2457519 https://doi.org/10.1016/j.envres.2017.06.007 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Glaucous Gull Larus hyperboreus |
genre_facet |
Arctic Glaucous Gull Larus hyperboreus |
op_source |
350-357 158 Environmental Research |
op_relation |
Environmental Research. 2017, 158 350-357. urn:issn:0013-9351 http://hdl.handle.net/11250/2457519 https://doi.org/10.1016/j.envres.2017.06.007 cristin:1493658 |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.envres.2017.06.007 |
container_title |
Environmental Research |
container_volume |
158 |
container_start_page |
350 |
op_container_end_page |
357 |
_version_ |
1766339905607172096 |