陸生哺乳類動物世代長短對輻射遺傳效應風險改變之推測與比較

碩士國立清華大學工程與系統科學系 GH009511508 從1977年開始人類建立了一套專屬於人的輻射防護機制，近年則開始以人為輻射防護的中心開始關心周圍的生態與環境保護，因此本文想探討人與陸生哺乳類動物因世代長短不同對於輻射遺傳效應的風險分別會有不同的結果。本文中有介紹輻射效應的種類，主要分為確定效應與機率效應，而輻射遺傳效應屬於機率效應的一種，輻射遺傳效應下面又再細分三種不同的遺傳疾病：孟德爾遺傳學說疾病、多因疾病以及染色體遺傳疾病，由於本文使用的方法只適用於低線性能量轉移的輻射源，所以並不是所有的輻射來源都適用，所以也需要探討輻射的來源；文中也解釋為何選擇陸生哺乳類動物做為探討的對...

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Main Authors:	陳巧柔, Chiao-Jou Chen
Other Authors:	李四海, Shih-Hai Li
Language:	Chinese
Published:	2008
Subjects:	遺傳效應風險陸生哺乳類動物加倍劑量法 heretitary effect heretitary disease effect risk doubling dose 22 Arctic Rangifer
Online Access:	http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/34419

id	ftnthuniv:oai:nthur.lib.nthu.edu.tw:987654321/34419
record_format	openpolar
institution	Open Polar
collection	National Tsing Hua University Institutional Repository (NTHUR)
op_collection_id	ftnthuniv
language	Chinese
topic	遺傳效應風險陸生哺乳類動物加倍劑量法 heretitary effect heretitary disease effect risk doubling dose 22
spellingShingle	遺傳效應風險陸生哺乳類動物加倍劑量法 heretitary effect heretitary disease effect risk doubling dose 22 陳巧柔 Chiao-Jou Chen 陸生哺乳類動物世代長短對輻射遺傳效應風險改變之推測與比較
topic_facet	遺傳效應風險陸生哺乳類動物加倍劑量法 heretitary effect heretitary disease effect risk doubling dose 22
description	碩士國立清華大學工程與系統科學系 GH009511508 從1977年開始人類建立了一套專屬於人的輻射防護機制，近年則開始以人為輻射防護的中心開始關心周圍的生態與環境保護，因此本文想探討人與陸生哺乳類動物因世代長短不同對於輻射遺傳效應的風險分別會有不同的結果。本文中有介紹輻射效應的種類，主要分為確定效應與機率效應，而輻射遺傳效應屬於機率效應的一種，輻射遺傳效應下面又再細分三種不同的遺傳疾病：孟德爾遺傳學說疾病、多因疾病以及染色體遺傳疾病，由於本文使用的方法只適用於低線性能量轉移的輻射源，所以並不是所有的輻射來源都適用，所以也需要探討輻射的來源；文中也解釋為何選擇陸生哺乳類動物做為探討的對象，以及如何從中挑選出鹿以及鼠做為比較的對象，以及介紹人、鹿和鼠在生物方面的參數，除了世代長短外還包含性別比例、及生殖狀況等，這些參數主要是應用在推測遺傳效應風險的方法裡所需要用到的。本文使用修正過的加倍劑量法，增加了潛在修護修正因子，基本上是認為生物族群最後會達到動態的平衡，當沒有輻射照射時有一突變之基線頻率，每增加照射一定輻射劑量後會增加突變的風險，文中分兩種狀況，其一是只有母代受到照射，其二是連續世代均受到輻射之照射，無論是哪種狀況均須收集物種之生物特性以求得突變成因因子之數值以及潛在修護修正因子，將基線頻率、突變成因因子及潛在修護修正因子相乘後即可得遺傳效應之風險。無論何種狀況，世代越長族群達到新平衡的速度就越慢，反之則越快，因此可利用世代較短的物種評估輻射是否持續照射群體，進而改善所生長之環境，並且還可以由世代較短的物種得知輻射環境是否改善，而本身的世代較長的物種，即使是到下一代也不會受到很大的影響。
author2	李四海 Shih-Hai Li
author	陳巧柔 Chiao-Jou Chen
author_facet	陳巧柔 Chiao-Jou Chen
author_sort	陳巧柔
title	陸生哺乳類動物世代長短對輻射遺傳效應風險改變之推測與比較
title_short	陸生哺乳類動物世代長短對輻射遺傳效應風險改變之推測與比較
title_full	陸生哺乳類動物世代長短對輻射遺傳效應風險改變之推測與比較
title_fullStr	陸生哺乳類動物世代長短對輻射遺傳效應風險改變之推測與比較
title_full_unstemmed	陸生哺乳類動物世代長短對輻射遺傳效應風險改變之推測與比較
title_sort	陸生哺乳類動物世代長短對輻射遺傳效應風險改變之推測與比較
publishDate	2008
url	http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/34419
genre	Arctic Rangifer
genre_facet	Arctic Rangifer
op_relation	1. ICRP (1991) Recommendations of the International Commission on Radiological Protection, Publication 60. Annals of ICRP 21(1-3),p.1-89 2. ICRP (1998) Genetic susceptibility to cancar,Publication79.Annals of ICRP28(1-2),p.1-157 3. ICRP (1998) Biological Effects after Prenatal Irradiation (Embryo and Fetus), Publication 83.Annals of ICRP 29(3-4),p.13-62,85-127 4. ICRP (2003) Biological Effects after Prenatal Irradiation (Embryo and Fetus), Publication 90.Annals of ICRP 33(1-2),p12-56,121-182,196-200. 5. ICRP (2003) A Framework for Assessing the Impact of Ionising Radiation on Non-Human Species, Publication 91, Annals of ICRP33(3),p.214-256 6. ICRP (2005) Low Dose Extrapolation of Radiation-related cancer risk, Publication 99. Annals of ICRP35(4),p.26-54,64-132 7. ICRP (2007) Environmental Protection: the Concept and Use of Reference Animals and Plants, Publication XXX (Draft 4a),all 8. ICRP(2008) The 2007 Recommendations of the International Commission on Radiological Protection. Annals of ICRP37(2-4).p.9-79 9. The National Academies (1981), THE EFFECTS ON POPULATIONS OF EXPOSURE TO LOW LEVELS OF IONISING RADIATION, BEIR III,p.18-20 10. The National Academies (1988) Health Risks of Radon and Other Internally Deposited Alpha-Emitters, BEIR IV,all 11. The National Academies (1990) Health Risks from Exposure to Low Levels of Ionizing Radiation, BEIR V,p.23-65,86-103,162-175 12. The National Academies (1998) Health Risks from Exposure to Low Levels of Ionizing Radiation, BEIR VII, Phase I,all 13. The National Academies (2006) Health Risks from Exposure to Low Levels of Ionizing Radiation, BEIR VII, Phase II,all 14. UNSCEAR (2000) United Nations Scientific Committee on the Effects of Atomic Radiation, Sources and Effects of Ionizing radiation,NY,USA,p.23 15. Journal of Animal Science(2008) Prion biology relevant to bovine spongiform encephalopathy,p.46-52,63-77 16. Journal of Environmental Radioactivity 74 (2004) Radionuclide speciation and its relevance in environmental impact assessments, B. Salbu, O. C. Lind and L. Skipperud,p.233-24217. Environmental Sciences Division, Publication No. 4494(1995), Effects of Ionizing Radiation on Terrestrial Plants and Animals: A workshop Report, Lawrence W. Barnthouse,p.3-18 18. JSTOR, Use of X-Ray in Determining Pregnancy in Deer ,The Journal of Wildlife Management, 26( 4) (Oct., 1962),p. 409-411http://www.jstor.org/pss/3798022 19. Protection of Non-human Species from Ionising Radiation；Lars-Erik Holm,p.162-198,http://www.srp-uk.org/utrecht/utr34.pdf 20. The mammal society；http://www.abdn.ac.uk/mammal/deer.shtml 21. Neurological Review Emerging Pharmacotherapies for Creutzfeldt-Jakob Disease ；Carsten Korth, MD; Peter J. Peters, PhD.http://archneur.ama-assn.org/cgi/reprint/63/4/497.pdf 22. Canadian Cooperative Wildlife Health Centre, (1996), Canadian Cooperative Wildlife Health Centre: University of Nebraska – Lincoln, Volume 4-2,p.37-72,87-91 23. Deer Health；http://www.whitetailquest.com/deerhealth.html 24. National Institute for Biological Standards and Control, NIBSC, CJD Resource Cntre; http://www.nibsc.ac.uk/CJD/ 25. Molecular Biology and Evolution(2003), Estimating the Distribution of Selection Coefficients from Phylogenetic Data with Applications to Mitochondrial and Viral DNA；Rasmus Nielsen and Ziheng Yang,p.all;http://mbe.oxfordjournals.org/cgi/reprint/20/8/1231 26. Microevolution - Population Genetics Evolutionary Biology (BI 25) Lecture Notes, http://www.anselm.edu/homepage/jpitocch/evolution/evolmicro.html 27. Genetic risks of exposure to ionizing radiation: current estimates of scientific organizations involved in radiation risk estimation, the uncertainties and research needs(1998) Genetic Major impacts of gonadal mosaicism on hereditary risk estimation, origin of hereditary diseases, and evolution ,102/103,p.445–462 28. The Science of The Total Environment(1992)；Regional variation in radionuclide concentrations and radiation dose in caribou (Rangifer tarandus) in the Canadian Arctic,vol.182, MACDONALD C. R., EWING L. L. , ELKIN B. T. , WIEWEL A. M.,p.53-73 29. International Journal of Low Radiation, IJLR (2007) Suicides and Exposure to Low Doses of Ionising Radiation; K. Loganovsky, 4[3],p.176-183 30. 行政院主計處第三局第二科國情統計通報：近十年人類平均壽命概況; http: //www.stat.gov.tw/ct.asp?xItem=11440&ctNode=3259 31. 行政院主計處第三局第二科國情統計通報：全球總生育率概況; http://www.dgbas.gov.tw/public/Data/7651553871.pdf 32. 中華民國核能協會; http://www.chns.org/index.php 33. 哺乳類動物介紹;http://www.tchcc.gov.tw/air_art/program/nat_019.htm 38 34. 自體隱性疾病與近親通婚(2007);簡穎秀醫師; http://www.genes-at-taiwan.com.tw/genehelp/Sense/news_7.htm 35. 疾病介紹(2006)；台大醫院基因醫學部分子細胞遺傳檢驗室; http://ntuh.mc.ntu.edu.tw/gene/prenatal_cytolab/news.html 36. 生物進化論的發展(2007); http://www.ehappystudy.com/html/5/289/295/2007/4/ li57662385901470022720-0.htm 37. 天擇對基因的影響(1998),D.L. Hartl & E. W. Jones. Genetics. Fourth edition. Jones & Bartlett. P.J. Russell. Genetics；http://vschool.scu.edu.tw/biology/content/genetics/ge075-1.htm 38. LET、RBE與對DNA的損傷(2003); http://www.myoops.org/twocw/mit/NR/rdonlyres/ Nuclear-Engineering/22-01Introduction-to-Ionizing-RadiationFall2003/243A1A6C-255B-42FB-9E2F-4DCBC2C4BE3A/0/let_and_rbe_tw.pdf,p.1-4
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spelling	ftnthuniv:oai:nthur.lib.nthu.edu.tw:987654321/34419 2023-05-15T14:28:24+02:00 陸生哺乳類動物世代長短對輻射遺傳效應風險改變之推測與比較 Estimation and Comparison of the Radiation Hereditary Disease Effect Risk with Terrestrial Mammal in Different Generation Length 陳巧柔 Chiao-Jou Chen 李四海 Shih-Hai Li 2008 155 bytes text/html http://nthur.lib.nthu.edu.tw/dspace/handle/987654321/34419 zh_TW chi 1. ICRP (1991) Recommendations of the International Commission on Radiological Protection, Publication 60. Annals of ICRP 21(1-3),p.1-89 2. ICRP (1998) Genetic susceptibility to cancar,Publication79.Annals of ICRP28(1-2),p.1-157 3. ICRP (1998) Biological Effects after Prenatal Irradiation (Embryo and Fetus), Publication 83.Annals of ICRP 29(3-4),p.13-62,85-127 4. ICRP (2003) Biological Effects after Prenatal Irradiation (Embryo and Fetus), Publication 90.Annals of ICRP 33(1-2),p12-56,121-182,196-200. 5. ICRP (2003) A Framework for Assessing the Impact of Ionising Radiation on Non-Human Species, Publication 91, Annals of ICRP33(3),p.214-256 6. ICRP (2005) Low Dose Extrapolation of Radiation-related cancer risk, Publication 99. Annals of ICRP35(4),p.26-54,64-132 7. ICRP (2007) Environmental Protection: the Concept and Use of Reference Animals and Plants, Publication XXX (Draft 4a),all 8. ICRP(2008) The 2007 Recommendations of the International Commission on Radiological Protection. Annals of ICRP37(2-4).p.9-79 9. The National Academies (1981), THE EFFECTS ON POPULATIONS OF EXPOSURE TO LOW LEVELS OF IONISING RADIATION, BEIR III,p.18-20 10. The National Academies (1988) Health Risks of Radon and Other Internally Deposited Alpha-Emitters, BEIR IV,all 11. The National Academies (1990) Health Risks from Exposure to Low Levels of Ionizing Radiation, BEIR V,p.23-65,86-103,162-175 12. The National Academies (1998) Health Risks from Exposure to Low Levels of Ionizing Radiation, BEIR VII, Phase I,all 13. The National Academies (2006) Health Risks from Exposure to Low Levels of Ionizing Radiation, BEIR VII, Phase II,all 14. UNSCEAR (2000) United Nations Scientific Committee on the Effects of Atomic Radiation, Sources and Effects of Ionizing radiation,NY,USA,p.23 15. Journal of Animal Science(2008) Prion biology relevant to bovine spongiform encephalopathy,p.46-52,63-77 16. Journal of Environmental Radioactivity 74 (2004) Radionuclide speciation and its relevance in environmental impact assessments, B. Salbu, O. C. Lind and L. Skipperud,p.233-24217. Environmental Sciences Division, Publication No. 4494(1995), Effects of Ionizing Radiation on Terrestrial Plants and Animals: A workshop Report, Lawrence W. Barnthouse,p.3-18 18. JSTOR, Use of X-Ray in Determining Pregnancy in Deer ,The Journal of Wildlife Management, 26( 4) (Oct., 1962),p. 409-411http://www.jstor.org/pss/3798022 19. Protection of Non-human Species from Ionising Radiation；Lars-Erik Holm,p.162-198,http://www.srp-uk.org/utrecht/utr34.pdf 20. The mammal society；http://www.abdn.ac.uk/mammal/deer.shtml 21. Neurological Review Emerging Pharmacotherapies for Creutzfeldt-Jakob Disease ；Carsten Korth, MD; Peter J. Peters, PhD.http://archneur.ama-assn.org/cgi/reprint/63/4/497.pdf 22. Canadian Cooperative Wildlife Health Centre, (1996), Canadian Cooperative Wildlife Health Centre: University of Nebraska – Lincoln, Volume 4-2,p.37-72,87-91 23. Deer Health；http://www.whitetailquest.com/deerhealth.html 24. National Institute for Biological Standards and Control, NIBSC, CJD Resource Cntre; http://www.nibsc.ac.uk/CJD/ 25. Molecular Biology and Evolution(2003), Estimating the Distribution of Selection Coefficients from Phylogenetic Data with Applications to Mitochondrial and Viral DNA；Rasmus Nielsen and Ziheng Yang,p.all;http://mbe.oxfordjournals.org/cgi/reprint/20/8/1231 26. Microevolution - Population Genetics Evolutionary Biology (BI 25) Lecture Notes, http://www.anselm.edu/homepage/jpitocch/evolution/evolmicro.html 27. Genetic risks of exposure to ionizing radiation: current estimates of scientific organizations involved in radiation risk estimation, the uncertainties and research needs(1998) Genetic Major impacts of gonadal mosaicism on hereditary risk estimation, origin of hereditary diseases, and evolution ,102/103,p.445–462 28. The Science of The Total Environment(1992)；Regional variation in radionuclide concentrations and radiation dose in caribou (Rangifer tarandus) in the Canadian Arctic,vol.182, MACDONALD C. R., EWING L. L. , ELKIN B. T. , WIEWEL A. M.,p.53-73 29. International Journal of Low Radiation, IJLR (2007) Suicides and Exposure to Low Doses of Ionising Radiation; K. Loganovsky, 4[3],p.176-183 30. 行政院主計處第三局第二科國情統計通報：近十年人類平均壽命概況; http: //www.stat.gov.tw/ct.asp?xItem=11440&ctNode=3259 31. 行政院主計處第三局第二科國情統計通報：全球總生育率概況; http://www.dgbas.gov.tw/public/Data/7651553871.pdf 32. 中華民國核能協會; http://www.chns.org/index.php 33. 哺乳類動物介紹;http://www.tchcc.gov.tw/air_art/program/nat_019.htm 38 34. 自體隱性疾病與近親通婚(2007);簡穎秀醫師; http://www.genes-at-taiwan.com.tw/genehelp/Sense/news_7.htm 35. 疾病介紹(2006)；台大醫院基因醫學部分子細胞遺傳檢驗室; http://ntuh.mc.ntu.edu.tw/gene/prenatal_cytolab/news.html 36. 生物進化論的發展(2007); http://www.ehappystudy.com/html/5/289/295/2007/4/ li57662385901470022720-0.htm 37. 天擇對基因的影響(1998),D.L. Hartl & E. W. Jones. Genetics. Fourth edition. Jones & Bartlett. P.J. Russell. Genetics；http://vschool.scu.edu.tw/biology/content/genetics/ge075-1.htm 38. LET、RBE與對DNA的損傷(2003); http://www.myoops.org/twocw/mit/NR/rdonlyres/ Nuclear-Engineering/22-01Introduction-to-Ionizing-RadiationFall2003/243A1A6C-255B-42FB-9E2F-4DCBC2C4BE3A/0/let_and_rbe_tw.pdf,p.1-4 遺傳效應風險陸生哺乳類動物加倍劑量法 heretitary effect heretitary disease effect risk doubling dose 22 2008 ftnthuniv 2014-12-17T20:16:29Z 碩士國立清華大學工程與系統科學系 GH009511508 從1977年開始人類建立了一套專屬於人的輻射防護機制，近年則開始以人為輻射防護的中心開始關心周圍的生態與環境保護，因此本文想探討人與陸生哺乳類動物因世代長短不同對於輻射遺傳效應的風險分別會有不同的結果。本文中有介紹輻射效應的種類，主要分為確定效應與機率效應，而輻射遺傳效應屬於機率效應的一種，輻射遺傳效應下面又再細分三種不同的遺傳疾病：孟德爾遺傳學說疾病、多因疾病以及染色體遺傳疾病，由於本文使用的方法只適用於低線性能量轉移的輻射源，所以並不是所有的輻射來源都適用，所以也需要探討輻射的來源；文中也解釋為何選擇陸生哺乳類動物做為探討的對象，以及如何從中挑選出鹿以及鼠做為比較的對象，以及介紹人、鹿和鼠在生物方面的參數，除了世代長短外還包含性別比例、及生殖狀況等，這些參數主要是應用在推測遺傳效應風險的方法裡所需要用到的。本文使用修正過的加倍劑量法，增加了潛在修護修正因子，基本上是認為生物族群最後會達到動態的平衡，當沒有輻射照射時有一突變之基線頻率，每增加照射一定輻射劑量後會增加突變的風險，文中分兩種狀況，其一是只有母代受到照射，其二是連續世代均受到輻射之照射，無論是哪種狀況均須收集物種之生物特性以求得突變成因因子之數值以及潛在修護修正因子，將基線頻率、突變成因因子及潛在修護修正因子相乘後即可得遺傳效應之風險。無論何種狀況，世代越長族群達到新平衡的速度就越慢，反之則越快，因此可利用世代較短的物種評估輻射是否持續照射群體，進而改善所生長之環境，並且還可以由世代較短的物種得知輻射環境是否改善，而本身的世代較長的物種，即使是到下一代也不會受到很大的影響。 Other/Unknown Material Arctic Rangifer National Tsing Hua University Institutional Repository (NTHUR)

陸生哺乳類動物世代長短對輻射遺傳效應風險改變之推測與比較

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