A process for synthesizing high purity monoglyceride
Synthesis of high-purity (>99%) monostearin was carried out using a two-step process. The first step involved lipase-assisted enzymatic esterification of fatty acid with glycerol catalyzed by immobilized lipase Candida antarctica (Novozym, 435) in acetone. The reaction was carried out at a fatty...
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ftntaiwanust:oai:ir.lib.ntust.edu.tw:987654321/33780 2023-05-15T13:50:22+02:00 A process for synthesizing high purity monoglyceride Yang, Y.C.;Vali, S.R.;Ju, Y.H. 2003 http://ir.lib.ntust.edu.tw/handle/987654321/33780 en_US eng Journal of the Chinese Institute of Chemical Engineers, Vol.34, No.6, pp.617-623 acylglycerols esterification lipase monoglycerides reaction equilibrium solvent polarity glycerolysis selectivity media Article 2003 ftntaiwanust 2019-06-28T00:32:43Z Synthesis of high-purity (>99%) monostearin was carried out using a two-step process. The first step involved lipase-assisted enzymatic esterification of fatty acid with glycerol catalyzed by immobilized lipase Candida antarctica (Novozym, 435) in acetone. The reaction was carried out at a fatty acid (FA) to glycerol molar ratio of 1:4 with 5% lipase based on the fatty acid (FA) weight. Equilibrium was attained within 8 h with a nionoglyceride (MG) content and a degree of esterification of 82.4 wt% and 85.5%, respectively. The addition of solvent shifted the equilibrium toward product formation and resulted in further increases of the MG content and the degree of esterification to 89.7 wt% and 92.7%, respectively, after 16 h (total: 24 h). The major impurities in the reaction product were free fatty acids (up to 7 wt%) and di- and triglycerides (<3.5%). The second step involved the removal of fatty acids by a mild alkali treatment, and it produced MG with purity greater than 99 wt% and an overall yield of 66.8%. Comparison of various solvents shows that the extent of esterification and product selectivity are strongly dependent on the solubility-solvation of the substrate and product in the reaction medium. Thus, monoglycerides was carried out using monostearin synthesis as model system in this investigation. Article in Journal/Newspaper Antarc* Antarctica National Taiwan University of Science and Technology Repository (NTUSTR) |
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Open Polar |
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National Taiwan University of Science and Technology Repository (NTUSTR) |
op_collection_id |
ftntaiwanust |
language |
English |
topic |
acylglycerols esterification lipase monoglycerides reaction equilibrium solvent polarity glycerolysis selectivity media |
spellingShingle |
acylglycerols esterification lipase monoglycerides reaction equilibrium solvent polarity glycerolysis selectivity media Yang, Y.C.;Vali, S.R.;Ju, Y.H. A process for synthesizing high purity monoglyceride |
topic_facet |
acylglycerols esterification lipase monoglycerides reaction equilibrium solvent polarity glycerolysis selectivity media |
description |
Synthesis of high-purity (>99%) monostearin was carried out using a two-step process. The first step involved lipase-assisted enzymatic esterification of fatty acid with glycerol catalyzed by immobilized lipase Candida antarctica (Novozym, 435) in acetone. The reaction was carried out at a fatty acid (FA) to glycerol molar ratio of 1:4 with 5% lipase based on the fatty acid (FA) weight. Equilibrium was attained within 8 h with a nionoglyceride (MG) content and a degree of esterification of 82.4 wt% and 85.5%, respectively. The addition of solvent shifted the equilibrium toward product formation and resulted in further increases of the MG content and the degree of esterification to 89.7 wt% and 92.7%, respectively, after 16 h (total: 24 h). The major impurities in the reaction product were free fatty acids (up to 7 wt%) and di- and triglycerides (<3.5%). The second step involved the removal of fatty acids by a mild alkali treatment, and it produced MG with purity greater than 99 wt% and an overall yield of 66.8%. Comparison of various solvents shows that the extent of esterification and product selectivity are strongly dependent on the solubility-solvation of the substrate and product in the reaction medium. Thus, monoglycerides was carried out using monostearin synthesis as model system in this investigation. |
format |
Article in Journal/Newspaper |
author |
Yang, Y.C.;Vali, S.R.;Ju, Y.H. |
author_facet |
Yang, Y.C.;Vali, S.R.;Ju, Y.H. |
author_sort |
Yang, Y.C.;Vali, S.R.;Ju, Y.H. |
title |
A process for synthesizing high purity monoglyceride |
title_short |
A process for synthesizing high purity monoglyceride |
title_full |
A process for synthesizing high purity monoglyceride |
title_fullStr |
A process for synthesizing high purity monoglyceride |
title_full_unstemmed |
A process for synthesizing high purity monoglyceride |
title_sort |
process for synthesizing high purity monoglyceride |
publishDate |
2003 |
url |
http://ir.lib.ntust.edu.tw/handle/987654321/33780 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
Journal of the Chinese Institute of Chemical Engineers, Vol.34, No.6, pp.617-623 |
_version_ |
1766253439218614272 |