Glucose Kinetics in Neonatal Elephant Seals During Postweaning Aphagia
Northern elephant seal (Mirounga angustirostris) pups undergo extended periods of terrestrial aphagia after weaning and exhibit a paradoxical fasting hyperglycemia. To investigate the details of glucose metabolism during this period, reversible and irreversible radiotracers were used to determine th...
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ftnsoutheastern:oai:nsuworks.nova.edu:occ_facarticles-1695 2023-05-15T16:05:12+02:00 Glucose Kinetics in Neonatal Elephant Seals During Postweaning Aphagia Keith, Edward O. Ortiz, Charles L. 1989-04-01T08:00:00Z https://nsuworks.nova.edu/occ_facarticles/673 unknown NSUWorks https://nsuworks.nova.edu/occ_facarticles/673 Marine & Environmental Sciences Faculty Articles Northern elephant seal Glucose metabolism Fasting Marine Biology Oceanography and Atmospheric Sciences and Meteorology article 1989 ftnsoutheastern 2022-04-10T21:33:22Z Northern elephant seal (Mirounga angustirostris) pups undergo extended periods of terrestrial aphagia after weaning and exhibit a paradoxical fasting hyperglycemia. To investigate the details of glucose metabolism during this period, reversible and irreversible radiotracers were used to determine the body mass of glucose, and rates of glucose turnover, recycling, and oxidation in fasting seal pups. A typical 75 kg pup has a glucose mass of about 4.5 g (60 mg/kg), and a blood glucose concentration of about 174 mg/dl. Blood glucose removal rate was about 30 grams per day (17 mg/kg · h-1), but less than 2.5% of this glucose was oxidized, contributing less than 1% of the total metabolic rate. About 20% of the glucose pool was removed from the blood per hour, yielding a turnover time in the vascular space of about five hours. Most glucose removed from the blood was returned to the blood by recycling. Such recycling may contribute to mechanisms which prolong survival during fasting, such as high rates of triacyclglycerol turnover, synthesis of new protein pools, low ketone levels, and the Cori cycle which is important during diving. Article in Journal/Newspaper Elephant Seal Elephant Seals Nova Southeastern University: NSU Works |
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Open Polar |
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Nova Southeastern University: NSU Works |
op_collection_id |
ftnsoutheastern |
language |
unknown |
topic |
Northern elephant seal Glucose metabolism Fasting Marine Biology Oceanography and Atmospheric Sciences and Meteorology |
spellingShingle |
Northern elephant seal Glucose metabolism Fasting Marine Biology Oceanography and Atmospheric Sciences and Meteorology Keith, Edward O. Ortiz, Charles L. Glucose Kinetics in Neonatal Elephant Seals During Postweaning Aphagia |
topic_facet |
Northern elephant seal Glucose metabolism Fasting Marine Biology Oceanography and Atmospheric Sciences and Meteorology |
description |
Northern elephant seal (Mirounga angustirostris) pups undergo extended periods of terrestrial aphagia after weaning and exhibit a paradoxical fasting hyperglycemia. To investigate the details of glucose metabolism during this period, reversible and irreversible radiotracers were used to determine the body mass of glucose, and rates of glucose turnover, recycling, and oxidation in fasting seal pups. A typical 75 kg pup has a glucose mass of about 4.5 g (60 mg/kg), and a blood glucose concentration of about 174 mg/dl. Blood glucose removal rate was about 30 grams per day (17 mg/kg · h-1), but less than 2.5% of this glucose was oxidized, contributing less than 1% of the total metabolic rate. About 20% of the glucose pool was removed from the blood per hour, yielding a turnover time in the vascular space of about five hours. Most glucose removed from the blood was returned to the blood by recycling. Such recycling may contribute to mechanisms which prolong survival during fasting, such as high rates of triacyclglycerol turnover, synthesis of new protein pools, low ketone levels, and the Cori cycle which is important during diving. |
format |
Article in Journal/Newspaper |
author |
Keith, Edward O. Ortiz, Charles L. |
author_facet |
Keith, Edward O. Ortiz, Charles L. |
author_sort |
Keith, Edward O. |
title |
Glucose Kinetics in Neonatal Elephant Seals During Postweaning Aphagia |
title_short |
Glucose Kinetics in Neonatal Elephant Seals During Postweaning Aphagia |
title_full |
Glucose Kinetics in Neonatal Elephant Seals During Postweaning Aphagia |
title_fullStr |
Glucose Kinetics in Neonatal Elephant Seals During Postweaning Aphagia |
title_full_unstemmed |
Glucose Kinetics in Neonatal Elephant Seals During Postweaning Aphagia |
title_sort |
glucose kinetics in neonatal elephant seals during postweaning aphagia |
publisher |
NSUWorks |
publishDate |
1989 |
url |
https://nsuworks.nova.edu/occ_facarticles/673 |
genre |
Elephant Seal Elephant Seals |
genre_facet |
Elephant Seal Elephant Seals |
op_source |
Marine & Environmental Sciences Faculty Articles |
op_relation |
https://nsuworks.nova.edu/occ_facarticles/673 |
_version_ |
1766401089793425408 |