The Russian Genome Project
The Russian Federation spans 11 time zones and is the home of ~146,000,000 people: 80% are the ethnic Russians and the remainder identify themselves as one of ~200 indigenous ethnic minorities. Despite the large population size and high ethnic diversity, no centralized reference database of function...
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ftnsoutheastern:oai:nsuworks.nova.edu:cnso_osj-1180 2023-05-15T18:45:05+02:00 The Russian Genome Project O'Brien, Stephen James 2020-02-11T19:45:00Z https://nsuworks.nova.edu/cnso_osj/february-2020/day2/26 unknown NSUWorks https://nsuworks.nova.edu/cnso_osj/february-2020/day2/26 HCAS Ocean Science Research Symposium Biology Marine Biology Oceanography Oceanography and Atmospheric Sciences and Meteorology text 2020 ftnsoutheastern 2022-04-10T22:09:48Z The Russian Federation spans 11 time zones and is the home of ~146,000,000 people: 80% are the ethnic Russians and the remainder identify themselves as one of ~200 indigenous ethnic minorities. Despite the large population size and high ethnic diversity, no centralized reference database of functional and endemic genetic variation has been established to date. The national Genome Russia Project aims to perform high coverage whole genome sequencing and analysis of peoples of the Russian Federation. I shall describe our progress based upon resolving genome-wide variation (SNPs, indels, and copy number variation) from 264 healthy adults, including 60 newly sequenced samples consisting of family trios from three geographic regions: Pskov, Novgorod and Yakutia,. People of Russia are shown to carry known and novel genetic variants of adaptive, clinical and functional consequence that in many cases show appreciable occurrence or allele frequency divergence from the neighboring Eurasian populations. Population genetic phylogenetic analyses revealed strong geographic partitions among indigenous ethnicities corresponding to the geographic locales where they have lived. Allele frequency spectra identified strong constraints to gene flow corresponding to the geological barriers (e.g. the Ural Mountains and Verkhoyansk mountain range). These first conclusions of the Genome Russia Project include results important for medical genetics as well as for population natural history studies and are at present being extended with several hundred additional Russian genomes. Text Yakutia Nova Southeastern University: NSU Works Verkhoyansk ENVELOPE(133.400,133.400,67.544,67.544) |
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Nova Southeastern University: NSU Works |
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Biology Marine Biology Oceanography Oceanography and Atmospheric Sciences and Meteorology |
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Biology Marine Biology Oceanography Oceanography and Atmospheric Sciences and Meteorology O'Brien, Stephen James The Russian Genome Project |
topic_facet |
Biology Marine Biology Oceanography Oceanography and Atmospheric Sciences and Meteorology |
description |
The Russian Federation spans 11 time zones and is the home of ~146,000,000 people: 80% are the ethnic Russians and the remainder identify themselves as one of ~200 indigenous ethnic minorities. Despite the large population size and high ethnic diversity, no centralized reference database of functional and endemic genetic variation has been established to date. The national Genome Russia Project aims to perform high coverage whole genome sequencing and analysis of peoples of the Russian Federation. I shall describe our progress based upon resolving genome-wide variation (SNPs, indels, and copy number variation) from 264 healthy adults, including 60 newly sequenced samples consisting of family trios from three geographic regions: Pskov, Novgorod and Yakutia,. People of Russia are shown to carry known and novel genetic variants of adaptive, clinical and functional consequence that in many cases show appreciable occurrence or allele frequency divergence from the neighboring Eurasian populations. Population genetic phylogenetic analyses revealed strong geographic partitions among indigenous ethnicities corresponding to the geographic locales where they have lived. Allele frequency spectra identified strong constraints to gene flow corresponding to the geological barriers (e.g. the Ural Mountains and Verkhoyansk mountain range). These first conclusions of the Genome Russia Project include results important for medical genetics as well as for population natural history studies and are at present being extended with several hundred additional Russian genomes. |
format |
Text |
author |
O'Brien, Stephen James |
author_facet |
O'Brien, Stephen James |
author_sort |
O'Brien, Stephen James |
title |
The Russian Genome Project |
title_short |
The Russian Genome Project |
title_full |
The Russian Genome Project |
title_fullStr |
The Russian Genome Project |
title_full_unstemmed |
The Russian Genome Project |
title_sort |
russian genome project |
publisher |
NSUWorks |
publishDate |
2020 |
url |
https://nsuworks.nova.edu/cnso_osj/february-2020/day2/26 |
long_lat |
ENVELOPE(133.400,133.400,67.544,67.544) |
geographic |
Verkhoyansk |
geographic_facet |
Verkhoyansk |
genre |
Yakutia |
genre_facet |
Yakutia |
op_source |
HCAS Ocean Science Research Symposium |
op_relation |
https://nsuworks.nova.edu/cnso_osj/february-2020/day2/26 |
_version_ |
1766236044258181120 |