Effects of biometrics, location and persistent organic pollutants on blood clinical-chemical parameters in polar bears (Ursus maritimus) from Svalbard, Norway
Embargo until 31 May 2020. In the present study, blood clinical-chemical parameters (BCCPs) were analysed in 20 female and 18 male Svalbard polar bears (Ursus maritimus) captured in spring 2007. The aim was to study how age, body condition (BC), biometrics, plasma lipid content and geographical loca...
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Online Access: | http://hdl.handle.net/11250/2602061 https://doi.org/10.1016/j.envres.2018.04.026 |
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ftnorskinstvf:oai:niva.brage.unit.no:11250/2602061 2023-05-15T18:29:46+02:00 Effects of biometrics, location and persistent organic pollutants on blood clinical-chemical parameters in polar bears (Ursus maritimus) from Svalbard, Norway Ciesielski, Tomasz Maciej Sonne, Christian Ormbostad, Ingunn Aars, Jon Lie, Elisabeth Bytingsvik, Jenny Jenssen, Bjørn Munro 2018 application/pdf http://hdl.handle.net/11250/2602061 https://doi.org/10.1016/j.envres.2018.04.026 eng eng Elsevier Norges forskningsråd: 175989 Environmental Research. 2018, 165, 387-399. urn:issn:0013-9351 http://hdl.handle.net/11250/2602061 https://doi.org/10.1016/j.envres.2018.04.026 cristin:1596097 Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no CC-BY-NC-ND 387-399 165 Environmental Research Journal article Peer reviewed 2018 ftnorskinstvf https://doi.org/10.1016/j.envres.2018.04.026 2023-02-21T08:46:25Z Embargo until 31 May 2020. In the present study, blood clinical-chemical parameters (BCCPs) were analysed in 20 female and 18 male Svalbard polar bears (Ursus maritimus) captured in spring 2007. The aim was to study how age, body condition (BC), biometrics, plasma lipid content and geographical location may confound the relationship between persistent organic pollutants (POPs) including PCBs, HCB, chlordanes, DDTs, HCHs, mirex and OH-PCBs and the concentrations of 12 specific BCCPs (hematocrit [HCT], hemoglobin [HB], aspartate aminotransferase [ASAT], alanine aminotransferase [ALAT], γ-glutamyltransferase [GGT], creatine kinase [CK], triglycerides [TG], cholesterol [CHOL], high-density lipoprotein [HDL], creatinine (CREA], urea, potassium (K]), and to investigate if any of these BCCPs may be applied as potential biomarkers for POP exposure in polar bears. Initial PCA and O-PLS modelling showed that age, lipids, BC and geographical location (longitude and latitude) were important parameters explaining BCCPs in females. Following subsequent partial correlation analyses correcting for age and lipids, multiple POPs in females were still significantly correlated with HCT and HDL (all p < 0.05). In males, age, BM, BC and longitude were important parameters explaining BCCPs. Following partial correlation analyses correcting for age, biometrics, lipids and longitude in males, multiple POPs were significantly correlated with HCT, ASAT, GGT and CHOL (all p < 0.05). In conclusion, several confounding parameters has to be taken into account when studying the relations between BCCPs and POPs in polar bears. When correcting for these, in particular HCT may be used as a simple cost-efficient biomarker of POP exposure in polar bears. Furthermore, decreasing HDL concentrations and increasing CHOL concentration with increasing POP concentrations may indicate responses related to increased risk of cardiovascular disease. We therefore suggest to further study POP exposure and lipidome response to increase knowledge of the ... Article in Journal/Newspaper Svalbard Ursus maritimus Norwegian Institute for Water research: NIVA Open Access Archive (Brage) Norway Svalbard Environmental Research 165 387 399 |
institution |
Open Polar |
collection |
Norwegian Institute for Water research: NIVA Open Access Archive (Brage) |
op_collection_id |
ftnorskinstvf |
language |
English |
description |
Embargo until 31 May 2020. In the present study, blood clinical-chemical parameters (BCCPs) were analysed in 20 female and 18 male Svalbard polar bears (Ursus maritimus) captured in spring 2007. The aim was to study how age, body condition (BC), biometrics, plasma lipid content and geographical location may confound the relationship between persistent organic pollutants (POPs) including PCBs, HCB, chlordanes, DDTs, HCHs, mirex and OH-PCBs and the concentrations of 12 specific BCCPs (hematocrit [HCT], hemoglobin [HB], aspartate aminotransferase [ASAT], alanine aminotransferase [ALAT], γ-glutamyltransferase [GGT], creatine kinase [CK], triglycerides [TG], cholesterol [CHOL], high-density lipoprotein [HDL], creatinine (CREA], urea, potassium (K]), and to investigate if any of these BCCPs may be applied as potential biomarkers for POP exposure in polar bears. Initial PCA and O-PLS modelling showed that age, lipids, BC and geographical location (longitude and latitude) were important parameters explaining BCCPs in females. Following subsequent partial correlation analyses correcting for age and lipids, multiple POPs in females were still significantly correlated with HCT and HDL (all p < 0.05). In males, age, BM, BC and longitude were important parameters explaining BCCPs. Following partial correlation analyses correcting for age, biometrics, lipids and longitude in males, multiple POPs were significantly correlated with HCT, ASAT, GGT and CHOL (all p < 0.05). In conclusion, several confounding parameters has to be taken into account when studying the relations between BCCPs and POPs in polar bears. When correcting for these, in particular HCT may be used as a simple cost-efficient biomarker of POP exposure in polar bears. Furthermore, decreasing HDL concentrations and increasing CHOL concentration with increasing POP concentrations may indicate responses related to increased risk of cardiovascular disease. We therefore suggest to further study POP exposure and lipidome response to increase knowledge of the ... |
format |
Article in Journal/Newspaper |
author |
Ciesielski, Tomasz Maciej Sonne, Christian Ormbostad, Ingunn Aars, Jon Lie, Elisabeth Bytingsvik, Jenny Jenssen, Bjørn Munro |
spellingShingle |
Ciesielski, Tomasz Maciej Sonne, Christian Ormbostad, Ingunn Aars, Jon Lie, Elisabeth Bytingsvik, Jenny Jenssen, Bjørn Munro Effects of biometrics, location and persistent organic pollutants on blood clinical-chemical parameters in polar bears (Ursus maritimus) from Svalbard, Norway |
author_facet |
Ciesielski, Tomasz Maciej Sonne, Christian Ormbostad, Ingunn Aars, Jon Lie, Elisabeth Bytingsvik, Jenny Jenssen, Bjørn Munro |
author_sort |
Ciesielski, Tomasz Maciej |
title |
Effects of biometrics, location and persistent organic pollutants on blood clinical-chemical parameters in polar bears (Ursus maritimus) from Svalbard, Norway |
title_short |
Effects of biometrics, location and persistent organic pollutants on blood clinical-chemical parameters in polar bears (Ursus maritimus) from Svalbard, Norway |
title_full |
Effects of biometrics, location and persistent organic pollutants on blood clinical-chemical parameters in polar bears (Ursus maritimus) from Svalbard, Norway |
title_fullStr |
Effects of biometrics, location and persistent organic pollutants on blood clinical-chemical parameters in polar bears (Ursus maritimus) from Svalbard, Norway |
title_full_unstemmed |
Effects of biometrics, location and persistent organic pollutants on blood clinical-chemical parameters in polar bears (Ursus maritimus) from Svalbard, Norway |
title_sort |
effects of biometrics, location and persistent organic pollutants on blood clinical-chemical parameters in polar bears (ursus maritimus) from svalbard, norway |
publisher |
Elsevier |
publishDate |
2018 |
url |
http://hdl.handle.net/11250/2602061 https://doi.org/10.1016/j.envres.2018.04.026 |
geographic |
Norway Svalbard |
geographic_facet |
Norway Svalbard |
genre |
Svalbard Ursus maritimus |
genre_facet |
Svalbard Ursus maritimus |
op_source |
387-399 165 Environmental Research |
op_relation |
Norges forskningsråd: 175989 Environmental Research. 2018, 165, 387-399. urn:issn:0013-9351 http://hdl.handle.net/11250/2602061 https://doi.org/10.1016/j.envres.2018.04.026 cristin:1596097 |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.envres.2018.04.026 |
container_title |
Environmental Research |
container_volume |
165 |
container_start_page |
387 |
op_container_end_page |
399 |
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1766213133578272768 |