Primary hepatocytes from Arctic char (Salvelinus alpinus) as a relevant Arctic in vitro model for screening contaminants and environmental extracts

• Published in: Aquatic Toxicology
• Main Authors: Petersen, Karina, Hultman, Maria T, Tollefsen, Knut Erik
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2017
• Subjects: Arctic; Moa; Salvelinus alpinus
• Online Access: http://hdl.handle.net/11250/2561365; https://doi.org/10.1016/j.aquatox.2017.03.023

Embargo until 02 April 2019. Contaminants find their way to the Arctic through long-range atmospheric transport, transport via ocean currents, and through increased anthropogenic activity. Some of the typical pollutants reaching the Arctic (PAHs, PCBs) are known to induce cytochrome P450 1a (CYP1A)...