Short-term bioaccumulation, circulation and metabolism of estradiol-17β in the oyster Crassostrea gigas
International audience Steroids are active signal transmitters in Vertebrates. These roles have also been hypothesized in other Phyla and endocrine disrupting effects have been reported for different estrogen-like compounds in fishes and some marine invertebrates. As estradiol-17β has shown some phy...
Published in: | Journal of Experimental Marine Biology and Ecology |
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Online Access: | https://hal.science/hal-03039350 https://doi.org/10.1016/j.jembe.2005.04.027 |
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ftnormandieuniv:oai:HAL:hal-03039350v1 2024-04-28T08:16:26+00:00 Short-term bioaccumulation, circulation and metabolism of estradiol-17β in the oyster Crassostrea gigas Le Curieux-Belfond, O. Fievet, B. Séralini, G.E. Mathieu, M. Physiologie et Ecophysiologie des Mollusques Marins (PE2M) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS) Laboratoire de Radioécologie de Cherbourg-Octeville (IRSN/PSE-ENV/SRTE/LRC) Service de recherche sur les transferts et les effets des radionucléides sur les écosystèmes (IRSN/PSE-ENV/SRTE) Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN) 2005-11-29 https://hal.science/hal-03039350 https://doi.org/10.1016/j.jembe.2005.04.027 en eng HAL CCSD info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jembe.2005.04.027 hal-03039350 https://hal.science/hal-03039350 doi:10.1016/j.jembe.2005.04.027 Journal of Experimental Marine Biology and Ecology https://hal.science/hal-03039350 Journal of Experimental Marine Biology and Ecology, 2005, 325 (2), pp.125-133. ⟨10.1016/j.jembe.2005.04.027⟩ bioaccumulation biomarker bivalve estrogenic compound Bivalvia Crassostrea gigas Invertebrata Mollusca Ostreidae Pisces Vertebrata [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2005 ftnormandieuniv https://doi.org/10.1016/j.jembe.2005.04.027 2024-04-11T00:35:07Z International audience Steroids are active signal transmitters in Vertebrates. These roles have also been hypothesized in other Phyla and endocrine disrupting effects have been reported for different estrogen-like compounds in fishes and some marine invertebrates. As estradiol-17β has shown some physiological activities in the oyster and as estrogens or estrogen-like molecules can be present in water, we have investigated the bioaccumulation and metabolism of this estrogen in vivo in the oyster Crassostrea gigas. When dissolved in seawater, in less than 48 h estradiol-17β concentrated up to 31 times in the soft tissues of the suspension-feeder mollusc. Injected in the adductor muscle, estradiol-17β circulated from muscle to the gonad, the gills, the mantle, the labial palps, and to a lesser extent to the digestive gland. After 2 h, estradiol flow increased specifically towards this gland. Different hypotheses were raised concerning the circulation paths. However, in all cases estradiol metabolism primarily evidenced an in vivo transformation into estrone in the whole oyster and in its digestive gland. This strong 17β-hydroxysteroid-dehydrogenase activity confirms our previous in vitro results. In conclusion, it is proposed that oyster is able to take in charge estradiol as a potential contaminant in seawater. Therefore, its bioaccumulation and transformation into estrone could be studied as potential biomarkers of endocrine disruption. Furthermore, the experimental approach with dissolved steroids in the seawater combined to an anatomical screening appears as an interesting tool to investigate the bivalve endocrinology. © 2005 Elsevier B.V. All rights reserved. Article in Journal/Newspaper Crassostrea gigas Normandie Université: HAL Journal of Experimental Marine Biology and Ecology 325 2 125 133 |
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Open Polar |
collection |
Normandie Université: HAL |
op_collection_id |
ftnormandieuniv |
language |
English |
topic |
bioaccumulation biomarker bivalve estrogenic compound Bivalvia Crassostrea gigas Invertebrata Mollusca Ostreidae Pisces Vertebrata [SDV]Life Sciences [q-bio] |
spellingShingle |
bioaccumulation biomarker bivalve estrogenic compound Bivalvia Crassostrea gigas Invertebrata Mollusca Ostreidae Pisces Vertebrata [SDV]Life Sciences [q-bio] Le Curieux-Belfond, O. Fievet, B. Séralini, G.E. Mathieu, M. Short-term bioaccumulation, circulation and metabolism of estradiol-17β in the oyster Crassostrea gigas |
topic_facet |
bioaccumulation biomarker bivalve estrogenic compound Bivalvia Crassostrea gigas Invertebrata Mollusca Ostreidae Pisces Vertebrata [SDV]Life Sciences [q-bio] |
description |
International audience Steroids are active signal transmitters in Vertebrates. These roles have also been hypothesized in other Phyla and endocrine disrupting effects have been reported for different estrogen-like compounds in fishes and some marine invertebrates. As estradiol-17β has shown some physiological activities in the oyster and as estrogens or estrogen-like molecules can be present in water, we have investigated the bioaccumulation and metabolism of this estrogen in vivo in the oyster Crassostrea gigas. When dissolved in seawater, in less than 48 h estradiol-17β concentrated up to 31 times in the soft tissues of the suspension-feeder mollusc. Injected in the adductor muscle, estradiol-17β circulated from muscle to the gonad, the gills, the mantle, the labial palps, and to a lesser extent to the digestive gland. After 2 h, estradiol flow increased specifically towards this gland. Different hypotheses were raised concerning the circulation paths. However, in all cases estradiol metabolism primarily evidenced an in vivo transformation into estrone in the whole oyster and in its digestive gland. This strong 17β-hydroxysteroid-dehydrogenase activity confirms our previous in vitro results. In conclusion, it is proposed that oyster is able to take in charge estradiol as a potential contaminant in seawater. Therefore, its bioaccumulation and transformation into estrone could be studied as potential biomarkers of endocrine disruption. Furthermore, the experimental approach with dissolved steroids in the seawater combined to an anatomical screening appears as an interesting tool to investigate the bivalve endocrinology. © 2005 Elsevier B.V. All rights reserved. |
author2 |
Physiologie et Ecophysiologie des Mollusques Marins (PE2M) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS) Laboratoire de Radioécologie de Cherbourg-Octeville (IRSN/PSE-ENV/SRTE/LRC) Service de recherche sur les transferts et les effets des radionucléides sur les écosystèmes (IRSN/PSE-ENV/SRTE) Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN) |
format |
Article in Journal/Newspaper |
author |
Le Curieux-Belfond, O. Fievet, B. Séralini, G.E. Mathieu, M. |
author_facet |
Le Curieux-Belfond, O. Fievet, B. Séralini, G.E. Mathieu, M. |
author_sort |
Le Curieux-Belfond, O. |
title |
Short-term bioaccumulation, circulation and metabolism of estradiol-17β in the oyster Crassostrea gigas |
title_short |
Short-term bioaccumulation, circulation and metabolism of estradiol-17β in the oyster Crassostrea gigas |
title_full |
Short-term bioaccumulation, circulation and metabolism of estradiol-17β in the oyster Crassostrea gigas |
title_fullStr |
Short-term bioaccumulation, circulation and metabolism of estradiol-17β in the oyster Crassostrea gigas |
title_full_unstemmed |
Short-term bioaccumulation, circulation and metabolism of estradiol-17β in the oyster Crassostrea gigas |
title_sort |
short-term bioaccumulation, circulation and metabolism of estradiol-17β in the oyster crassostrea gigas |
publisher |
HAL CCSD |
publishDate |
2005 |
url |
https://hal.science/hal-03039350 https://doi.org/10.1016/j.jembe.2005.04.027 |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Journal of Experimental Marine Biology and Ecology https://hal.science/hal-03039350 Journal of Experimental Marine Biology and Ecology, 2005, 325 (2), pp.125-133. ⟨10.1016/j.jembe.2005.04.027⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jembe.2005.04.027 hal-03039350 https://hal.science/hal-03039350 doi:10.1016/j.jembe.2005.04.027 |
op_doi |
https://doi.org/10.1016/j.jembe.2005.04.027 |
container_title |
Journal of Experimental Marine Biology and Ecology |
container_volume |
325 |
container_issue |
2 |
container_start_page |
125 |
op_container_end_page |
133 |
_version_ |
1797581565138567168 |