Identification of Ras, Pten and p70S6K homologs in the Pacific oyster Crassostrea gigas and diet control of insulin pathway
International audience Insulin pathways were demonstrated from invertebrates to vertebrates to be involved in the regulation of numerous processes including storage metabolism and reproduction. In addition, insulin system may integrate variations of environmental conditions like dietary restrictions...
Published in: | General and Comparative Endocrinology |
---|---|
Main Authors: | , , , , , , |
Other Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2012
|
Subjects: | |
Online Access: | https://normandie-univ.hal.science/hal-02296527 https://doi.org/10.1016/j.ygcen.2011.12.008 |
id |
ftnormandieuniv:oai:HAL:hal-02296527v1 |
---|---|
record_format |
openpolar |
spelling |
ftnormandieuniv:oai:HAL:hal-02296527v1 2023-11-12T04:16:04+01:00 Identification of Ras, Pten and p70S6K homologs in the Pacific oyster Crassostrea gigas and diet control of insulin pathway Jouaux, A. Franco, A. Heude-Berthelin, C. Sourdaine, P. Blin, J.L. Mathieu, M. Kellner, K. Biologie des mollusques marins et des écosystèmes associés (BioMEA) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS) Synergie MEr et Littoral (SMEL) 2012-03 https://normandie-univ.hal.science/hal-02296527 https://doi.org/10.1016/j.ygcen.2011.12.008 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ygcen.2011.12.008 hal-02296527 https://normandie-univ.hal.science/hal-02296527 doi:10.1016/j.ygcen.2011.12.008 ISSN: 0016-6480 EISSN: 1095-6840 General and Comparative Endocrinology https://normandie-univ.hal.science/hal-02296527 General and Comparative Endocrinology, 2012, 176 (1), pp.28-38. ⟨10.1016/j.ygcen.2011.12.008⟩ p70S6K Pten Ras Insulin Crassostrea gigas Dietary restriction [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2012 ftnormandieuniv https://doi.org/10.1016/j.ygcen.2011.12.008 2023-10-17T22:47:49Z International audience Insulin pathways were demonstrated from invertebrates to vertebrates to be involved in the regulation of numerous processes including storage metabolism and reproduction. In addition, insulin system may integrate variations of environmental conditions like dietary restrictions. In the Pacific oyster Crassostrea gigas, reproductive and storage compartments are closely intricated in the gonadal area and their respective development was found to be dependant of trophic conditions. For these reasons, C. gigas is an original and interesting model for investigating the role of insulin control in the balance between storage and reproduction and the integration of environmental parameters. On the basis of sequence conservation, we identified three potential elements of the oyster insulin pathway, Ras, Pten and p70S6K and we investigated their expression levels in various tissues. In the gonadal area, we used laser microdissection in order to precise the targeted contribution of insulin signaling to the restoration of storage tissue and to the control of vitellogenesis. Food deprivation during gametogenesis reinitiation stage led to reduced proliferations of gonia and also to modulate insulin signal by transcriptional activation of insulin pathway elements. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Normandie Université: HAL Pacific General and Comparative Endocrinology 176 1 28 38 |
institution |
Open Polar |
collection |
Normandie Université: HAL |
op_collection_id |
ftnormandieuniv |
language |
English |
topic |
p70S6K Pten Ras Insulin Crassostrea gigas Dietary restriction [SDV]Life Sciences [q-bio] |
spellingShingle |
p70S6K Pten Ras Insulin Crassostrea gigas Dietary restriction [SDV]Life Sciences [q-bio] Jouaux, A. Franco, A. Heude-Berthelin, C. Sourdaine, P. Blin, J.L. Mathieu, M. Kellner, K. Identification of Ras, Pten and p70S6K homologs in the Pacific oyster Crassostrea gigas and diet control of insulin pathway |
topic_facet |
p70S6K Pten Ras Insulin Crassostrea gigas Dietary restriction [SDV]Life Sciences [q-bio] |
description |
International audience Insulin pathways were demonstrated from invertebrates to vertebrates to be involved in the regulation of numerous processes including storage metabolism and reproduction. In addition, insulin system may integrate variations of environmental conditions like dietary restrictions. In the Pacific oyster Crassostrea gigas, reproductive and storage compartments are closely intricated in the gonadal area and their respective development was found to be dependant of trophic conditions. For these reasons, C. gigas is an original and interesting model for investigating the role of insulin control in the balance between storage and reproduction and the integration of environmental parameters. On the basis of sequence conservation, we identified three potential elements of the oyster insulin pathway, Ras, Pten and p70S6K and we investigated their expression levels in various tissues. In the gonadal area, we used laser microdissection in order to precise the targeted contribution of insulin signaling to the restoration of storage tissue and to the control of vitellogenesis. Food deprivation during gametogenesis reinitiation stage led to reduced proliferations of gonia and also to modulate insulin signal by transcriptional activation of insulin pathway elements. |
author2 |
Biologie des mollusques marins et des écosystèmes associés (BioMEA) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS) Synergie MEr et Littoral (SMEL) |
format |
Article in Journal/Newspaper |
author |
Jouaux, A. Franco, A. Heude-Berthelin, C. Sourdaine, P. Blin, J.L. Mathieu, M. Kellner, K. |
author_facet |
Jouaux, A. Franco, A. Heude-Berthelin, C. Sourdaine, P. Blin, J.L. Mathieu, M. Kellner, K. |
author_sort |
Jouaux, A. |
title |
Identification of Ras, Pten and p70S6K homologs in the Pacific oyster Crassostrea gigas and diet control of insulin pathway |
title_short |
Identification of Ras, Pten and p70S6K homologs in the Pacific oyster Crassostrea gigas and diet control of insulin pathway |
title_full |
Identification of Ras, Pten and p70S6K homologs in the Pacific oyster Crassostrea gigas and diet control of insulin pathway |
title_fullStr |
Identification of Ras, Pten and p70S6K homologs in the Pacific oyster Crassostrea gigas and diet control of insulin pathway |
title_full_unstemmed |
Identification of Ras, Pten and p70S6K homologs in the Pacific oyster Crassostrea gigas and diet control of insulin pathway |
title_sort |
identification of ras, pten and p70s6k homologs in the pacific oyster crassostrea gigas and diet control of insulin pathway |
publisher |
HAL CCSD |
publishDate |
2012 |
url |
https://normandie-univ.hal.science/hal-02296527 https://doi.org/10.1016/j.ygcen.2011.12.008 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
ISSN: 0016-6480 EISSN: 1095-6840 General and Comparative Endocrinology https://normandie-univ.hal.science/hal-02296527 General and Comparative Endocrinology, 2012, 176 (1), pp.28-38. ⟨10.1016/j.ygcen.2011.12.008⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ygcen.2011.12.008 hal-02296527 https://normandie-univ.hal.science/hal-02296527 doi:10.1016/j.ygcen.2011.12.008 |
op_doi |
https://doi.org/10.1016/j.ygcen.2011.12.008 |
container_title |
General and Comparative Endocrinology |
container_volume |
176 |
container_issue |
1 |
container_start_page |
28 |
op_container_end_page |
38 |
_version_ |
1782333251388440576 |