Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes
Salmonid red blood cells are the main target cells for Piscine orthoreovirus (PRV). Three genotypes of PRV (PRV-1,2,3) infect Atlantic salmon (Salmo salar), Chinook salmon (Onchorhynchus tshawytscha), Coho salmon (Oncorhynchus kisutch), rainbow trout (Onchorhynchus mykiss) and brown trout (Salmo tru...
Published in: | Frontiers in Immunology |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2019
|
Subjects: | |
Online Access: | http://hdl.handle.net/11250/2591971 https://doi.org/10.3389/fimmu.2018.03182 |
id |
ftnofima:oai:nofima.brage.unit.no:11250/2591971 |
---|---|
record_format |
openpolar |
spelling |
ftnofima:oai:nofima.brage.unit.no:11250/2591971 2023-05-15T15:30:17+02:00 Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes Wessel, Øystein Krasnov, Aleksei Timmerhaus, Gerrit Rimstad, Espen Dahle, Maria 2019 application/pdf http://hdl.handle.net/11250/2591971 https://doi.org/10.3389/fimmu.2018.03182 eng eng Norges forskningsråd: 237315 Norges forskningsråd: 280847 Frontiers in Immunology. 2019, 9 1-6. urn:issn:1664-3224 http://hdl.handle.net/11250/2591971 https://doi.org/10.3389/fimmu.2018.03182 cristin:1685998 1-6 9 Frontiers in Immunology Peer reviewed Journal article 2019 ftnofima https://doi.org/10.3389/fimmu.2018.03182 2022-11-18T06:51:07Z Salmonid red blood cells are the main target cells for Piscine orthoreovirus (PRV). Three genotypes of PRV (PRV-1,2,3) infect Atlantic salmon (Salmo salar), Chinook salmon (Onchorhynchus tshawytscha), Coho salmon (Oncorhynchus kisutch), rainbow trout (Onchorhynchus mykiss) and brown trout (Salmo trutta), and can cause diseases like heart and skeletal muscle inflammation (HSMI), jaundice syndrome, erythrocyte inclusion body syndrome (EIBS) and proliferative darkening syndrome (PDS). Purified PRV administrated to fish has proven the causality for HSMI and EIBS. During the early peak phase of infection, salmonid erythrocytes are the main virus-replicating cells. In this initial phase, cytoplasmic inclusions called “virus factories” can be observed in the erythrocytes, and are the primary sites for the formation of new virus particles. The PRV-infected erythrocytes in Atlantic salmon mount a strong long-lasting innate antiviral response lasting for many weeks after the onset of infection. The antiviral response of Atlantic salmon erythrocytes involves upregulation of potential inhibitors of translation. In accordance with this, PRV-1 protein production in erythrocytes halts while virus RNA can persist for months. Furthermore, PRV infection in Coho salmon and rainbow trout are associated with anemia, and in Atlantic salmon lower hemoglobin levels are observed. Here we summarize and discuss the recently published findings on PRV infection, replication and effects on salmonid erythrocytes, and discuss how PRV can be a useful tool for the study of innate immune responses in erythrocytes, and help reveal novel immune functions of the red blood cells in fish. publishedVersion Article in Journal/Newspaper Atlantic salmon Salmo salar Nofima Knowledge Archive (Brage) Frontiers in Immunology 9 |
institution |
Open Polar |
collection |
Nofima Knowledge Archive (Brage) |
op_collection_id |
ftnofima |
language |
English |
description |
Salmonid red blood cells are the main target cells for Piscine orthoreovirus (PRV). Three genotypes of PRV (PRV-1,2,3) infect Atlantic salmon (Salmo salar), Chinook salmon (Onchorhynchus tshawytscha), Coho salmon (Oncorhynchus kisutch), rainbow trout (Onchorhynchus mykiss) and brown trout (Salmo trutta), and can cause diseases like heart and skeletal muscle inflammation (HSMI), jaundice syndrome, erythrocyte inclusion body syndrome (EIBS) and proliferative darkening syndrome (PDS). Purified PRV administrated to fish has proven the causality for HSMI and EIBS. During the early peak phase of infection, salmonid erythrocytes are the main virus-replicating cells. In this initial phase, cytoplasmic inclusions called “virus factories” can be observed in the erythrocytes, and are the primary sites for the formation of new virus particles. The PRV-infected erythrocytes in Atlantic salmon mount a strong long-lasting innate antiviral response lasting for many weeks after the onset of infection. The antiviral response of Atlantic salmon erythrocytes involves upregulation of potential inhibitors of translation. In accordance with this, PRV-1 protein production in erythrocytes halts while virus RNA can persist for months. Furthermore, PRV infection in Coho salmon and rainbow trout are associated with anemia, and in Atlantic salmon lower hemoglobin levels are observed. Here we summarize and discuss the recently published findings on PRV infection, replication and effects on salmonid erythrocytes, and discuss how PRV can be a useful tool for the study of innate immune responses in erythrocytes, and help reveal novel immune functions of the red blood cells in fish. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Wessel, Øystein Krasnov, Aleksei Timmerhaus, Gerrit Rimstad, Espen Dahle, Maria |
spellingShingle |
Wessel, Øystein Krasnov, Aleksei Timmerhaus, Gerrit Rimstad, Espen Dahle, Maria Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes |
author_facet |
Wessel, Øystein Krasnov, Aleksei Timmerhaus, Gerrit Rimstad, Espen Dahle, Maria |
author_sort |
Wessel, Øystein |
title |
Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes |
title_short |
Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes |
title_full |
Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes |
title_fullStr |
Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes |
title_full_unstemmed |
Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes |
title_sort |
antiviral responses and biological concequences of piscine orthoreovirus infection in salmonid erythrocytes |
publishDate |
2019 |
url |
http://hdl.handle.net/11250/2591971 https://doi.org/10.3389/fimmu.2018.03182 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
1-6 9 Frontiers in Immunology |
op_relation |
Norges forskningsråd: 237315 Norges forskningsråd: 280847 Frontiers in Immunology. 2019, 9 1-6. urn:issn:1664-3224 http://hdl.handle.net/11250/2591971 https://doi.org/10.3389/fimmu.2018.03182 cristin:1685998 |
op_doi |
https://doi.org/10.3389/fimmu.2018.03182 |
container_title |
Frontiers in Immunology |
container_volume |
9 |
_version_ |
1766360736433438720 |