High fish density delays wound healing in Atlantic salmon (Salmo salar)
In this study, we look closer at how high fish densities influence wound repair mechanisms in post-smolt Atlantic salmon. The fish were wounded with a 5 mm skin punch biopsy needle and stocked at two different densities, a high fish density (100 kg/m3) treatment and a low fish density treatment (20...
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ftnofima:oai:nofima.brage.unit.no:11250/2575990 2024-09-15T17:55:54+00:00 High fish density delays wound healing in Atlantic salmon (Salmo salar) Sveen, Lene Timmerhaus, Gerrit Krasnov, Aleksei Takle, Harald Stefansson, Sigurd Olav Handeland, Sigurd O Ytteborg, Elisabeth 2018 application/pdf http://hdl.handle.net/11250/2575990 https://doi.org/10.1038/s41598-018-35002-5 eng eng Norges forskningsråd: 237856 urn:issn:2045-2322 http://hdl.handle.net/11250/2575990 https://doi.org/10.1038/s41598-018-35002-5 cristin:1635194 8 Scientific Reports Peer reviewed Journal article 2018 ftnofima https://doi.org/10.1038/s41598-018-35002-5 2024-06-27T03:01:21Z In this study, we look closer at how high fish densities influence wound repair mechanisms in post-smolt Atlantic salmon. The fish were wounded with a 5 mm skin punch biopsy needle and stocked at two different densities, a high fish density (100 kg/m3) treatment and a low fish density treatment (20 kg/m3) serving as the control. The healing wounds were followed for 57 days with samples taken 1, 3, 7, 14, 36, 43 and 57 days post wounding. The transcriptomic analysis suggests that high fish density enhance inflammation and represses cell proliferation, tissue secretion and collagen synthesis in the healing wounds. The histological analysis further showed delayed epidermal and dermal repair in the high fish density treatment compared to control. The overall wound contraction was also altered by the treatment. In conclusion, high fish density enhances immune responses and delay tissue repair, which ultimately results in delayed wound healing. High fish density delays wound healing in Atlantic salmon (Salmo salar) publishedVersion Article in Journal/Newspaper Atlantic salmon Salmo salar Nofima Knowledge Archive (Brage) Scientific Reports 8 1 |
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Nofima Knowledge Archive (Brage) |
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English |
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In this study, we look closer at how high fish densities influence wound repair mechanisms in post-smolt Atlantic salmon. The fish were wounded with a 5 mm skin punch biopsy needle and stocked at two different densities, a high fish density (100 kg/m3) treatment and a low fish density treatment (20 kg/m3) serving as the control. The healing wounds were followed for 57 days with samples taken 1, 3, 7, 14, 36, 43 and 57 days post wounding. The transcriptomic analysis suggests that high fish density enhance inflammation and represses cell proliferation, tissue secretion and collagen synthesis in the healing wounds. The histological analysis further showed delayed epidermal and dermal repair in the high fish density treatment compared to control. The overall wound contraction was also altered by the treatment. In conclusion, high fish density enhances immune responses and delay tissue repair, which ultimately results in delayed wound healing. High fish density delays wound healing in Atlantic salmon (Salmo salar) publishedVersion |
format |
Article in Journal/Newspaper |
author |
Sveen, Lene Timmerhaus, Gerrit Krasnov, Aleksei Takle, Harald Stefansson, Sigurd Olav Handeland, Sigurd O Ytteborg, Elisabeth |
spellingShingle |
Sveen, Lene Timmerhaus, Gerrit Krasnov, Aleksei Takle, Harald Stefansson, Sigurd Olav Handeland, Sigurd O Ytteborg, Elisabeth High fish density delays wound healing in Atlantic salmon (Salmo salar) |
author_facet |
Sveen, Lene Timmerhaus, Gerrit Krasnov, Aleksei Takle, Harald Stefansson, Sigurd Olav Handeland, Sigurd O Ytteborg, Elisabeth |
author_sort |
Sveen, Lene |
title |
High fish density delays wound healing in Atlantic salmon (Salmo salar) |
title_short |
High fish density delays wound healing in Atlantic salmon (Salmo salar) |
title_full |
High fish density delays wound healing in Atlantic salmon (Salmo salar) |
title_fullStr |
High fish density delays wound healing in Atlantic salmon (Salmo salar) |
title_full_unstemmed |
High fish density delays wound healing in Atlantic salmon (Salmo salar) |
title_sort |
high fish density delays wound healing in atlantic salmon (salmo salar) |
publishDate |
2018 |
url |
http://hdl.handle.net/11250/2575990 https://doi.org/10.1038/s41598-018-35002-5 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
8 Scientific Reports |
op_relation |
Norges forskningsråd: 237856 urn:issn:2045-2322 http://hdl.handle.net/11250/2575990 https://doi.org/10.1038/s41598-018-35002-5 cristin:1635194 |
op_doi |
https://doi.org/10.1038/s41598-018-35002-5 |
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Scientific Reports |
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8 |
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1 |
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1810432121212239872 |