Antioxidant and Anti-Inflammatory Activities in Extracts from Minke Whale (Balaenoptera acutorostrata) Blubber
Intake of long-chain omega-3 polyunsaturated fatty acids (LC-n3-PUFA) is commonly recognized to reduce cardiovascular disease (CVD). In previous studies, cold-pressed whale oil (CWO) and cod liver oil (CLO) were given as a dietary supplement to healthy volunteers. Even though CWO contains less than...
Published in: | Mediators of Inflammation |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2017
|
Subjects: | |
Online Access: | http://hdl.handle.net/11250/2480584 https://doi.org/10.1155/2017/3835851 |
id |
ftnofima:oai:nofima.brage.unit.no:11250/2480584 |
---|---|
record_format |
openpolar |
spelling |
ftnofima:oai:nofima.brage.unit.no:11250/2480584 2023-05-15T15:36:08+02:00 Antioxidant and Anti-Inflammatory Activities in Extracts from Minke Whale (Balaenoptera acutorostrata) Blubber Walquist, Mari Stormo, Svein Kristian Jensen, Ida-Johanne Østerud, Bjarne Eilertsen, Karl-Erik 2017 application/pdf http://hdl.handle.net/11250/2480584 https://doi.org/10.1155/2017/3835851 eng eng https://www.hindawi.com/journals/mi/2017/3835851/ MABIT: UB0046 Mediators of Inflammation. 2017, . urn:issn:0962-9351 http://hdl.handle.net/11250/2480584 https://doi.org/10.1155/2017/3835851 cristin:1511721 9 Mediators of Inflammation Peer reviewed Journal article 2017 ftnofima https://doi.org/10.1155/2017/3835851 2022-11-18T06:51:11Z Intake of long-chain omega-3 polyunsaturated fatty acids (LC-n3-PUFA) is commonly recognized to reduce cardiovascular disease (CVD). In previous studies, cold-pressed whale oil (CWO) and cod liver oil (CLO) were given as a dietary supplement to healthy volunteers. Even though CWO contains less than half the amount of LC-n3-PUFA of CLO, CWO supplement resulted in beneficial effects on anti-inflammatory and CVD risk markers compared to CLO. In the present study, we prepared virtually lipid-free extracts from CWO and CLO and evaluated the antioxidative capacity (AOC) and anti-inflammatory effects. Oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays were used to test the AOC, and the results indicated high levels of antioxidants present in all extracts. The anti-inflammatory effects of the extracts were tested with lipopolysaccharide- (LPS-) treated THP-1 cells, measuring its ability to reduce cytokine and chemokine secretion. Several CWO extracts displayed anti-inflammatory activity, and a butyl alcohol extract of CWO most effectively reduced TNF-α (50%, ) and MCP-1 (85%, ) secretion. This extract maintained a stable effect of reducing MCP-1 secretion (60%, ) even after long-term storage. In conclusion, CWO has antioxidant and anti-inflammatory activities that may act in addition to its well-known LC-n3-PUFA effects. publishedVersion Article in Journal/Newspaper Balaenoptera acutorostrata minke whale Nofima Knowledge Archive (Brage) Mediators of Inflammation 2017 1 9 |
institution |
Open Polar |
collection |
Nofima Knowledge Archive (Brage) |
op_collection_id |
ftnofima |
language |
English |
description |
Intake of long-chain omega-3 polyunsaturated fatty acids (LC-n3-PUFA) is commonly recognized to reduce cardiovascular disease (CVD). In previous studies, cold-pressed whale oil (CWO) and cod liver oil (CLO) were given as a dietary supplement to healthy volunteers. Even though CWO contains less than half the amount of LC-n3-PUFA of CLO, CWO supplement resulted in beneficial effects on anti-inflammatory and CVD risk markers compared to CLO. In the present study, we prepared virtually lipid-free extracts from CWO and CLO and evaluated the antioxidative capacity (AOC) and anti-inflammatory effects. Oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays were used to test the AOC, and the results indicated high levels of antioxidants present in all extracts. The anti-inflammatory effects of the extracts were tested with lipopolysaccharide- (LPS-) treated THP-1 cells, measuring its ability to reduce cytokine and chemokine secretion. Several CWO extracts displayed anti-inflammatory activity, and a butyl alcohol extract of CWO most effectively reduced TNF-α (50%, ) and MCP-1 (85%, ) secretion. This extract maintained a stable effect of reducing MCP-1 secretion (60%, ) even after long-term storage. In conclusion, CWO has antioxidant and anti-inflammatory activities that may act in addition to its well-known LC-n3-PUFA effects. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Walquist, Mari Stormo, Svein Kristian Jensen, Ida-Johanne Østerud, Bjarne Eilertsen, Karl-Erik |
spellingShingle |
Walquist, Mari Stormo, Svein Kristian Jensen, Ida-Johanne Østerud, Bjarne Eilertsen, Karl-Erik Antioxidant and Anti-Inflammatory Activities in Extracts from Minke Whale (Balaenoptera acutorostrata) Blubber |
author_facet |
Walquist, Mari Stormo, Svein Kristian Jensen, Ida-Johanne Østerud, Bjarne Eilertsen, Karl-Erik |
author_sort |
Walquist, Mari |
title |
Antioxidant and Anti-Inflammatory Activities in Extracts from Minke Whale (Balaenoptera acutorostrata) Blubber |
title_short |
Antioxidant and Anti-Inflammatory Activities in Extracts from Minke Whale (Balaenoptera acutorostrata) Blubber |
title_full |
Antioxidant and Anti-Inflammatory Activities in Extracts from Minke Whale (Balaenoptera acutorostrata) Blubber |
title_fullStr |
Antioxidant and Anti-Inflammatory Activities in Extracts from Minke Whale (Balaenoptera acutorostrata) Blubber |
title_full_unstemmed |
Antioxidant and Anti-Inflammatory Activities in Extracts from Minke Whale (Balaenoptera acutorostrata) Blubber |
title_sort |
antioxidant and anti-inflammatory activities in extracts from minke whale (balaenoptera acutorostrata) blubber |
publishDate |
2017 |
url |
http://hdl.handle.net/11250/2480584 https://doi.org/10.1155/2017/3835851 |
genre |
Balaenoptera acutorostrata minke whale |
genre_facet |
Balaenoptera acutorostrata minke whale |
op_source |
9 Mediators of Inflammation |
op_relation |
https://www.hindawi.com/journals/mi/2017/3835851/ MABIT: UB0046 Mediators of Inflammation. 2017, . urn:issn:0962-9351 http://hdl.handle.net/11250/2480584 https://doi.org/10.1155/2017/3835851 cristin:1511721 |
op_doi |
https://doi.org/10.1155/2017/3835851 |
container_title |
Mediators of Inflammation |
container_volume |
2017 |
container_start_page |
1 |
op_container_end_page |
9 |
_version_ |
1766366477855752192 |