Influence of population density on antibiotic resistance
Antibiotic consumption and population density as a measure of crowding in the community were related to the prevalence of antibiotic resistance of three cities in three different countries: St Johns in Newfoundland (Canada), Athens in Greece and Groningen in The Netherlands. Antibiotic consumption w...
Main Authors: | , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2003
|
Subjects: | |
Online Access: | https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3022823 |
id |
ftnkunivathens:oai:lib.uoa.gr:uoadl:3022823 |
---|---|
record_format |
openpolar |
spelling |
ftnkunivathens:oai:lib.uoa.gr:uoadl:3022823 2024-02-11T10:05:56+01:00 Influence of population density on antibiotic resistance Bruinsma, N. Hutchinson, J.M. van den Bogaard, A.E. Giamarellou, H. Degener, J. Stobberingh, E.E. 2003-01-01 https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3022823 Αγγλικά English eng uoadl:3022823 https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3022823 scientific_publication_article Επιστημονική δημοσίευση - Άρθρο Περιοδικού Scientific publication - Journal Article 2003 ftnkunivathens 2024-01-18T18:46:01Z Antibiotic consumption and population density as a measure of crowding in the community were related to the prevalence of antibiotic resistance of three cities in three different countries: St Johns in Newfoundland (Canada), Athens in Greece and Groningen in The Netherlands. Antibiotic consumption was expressed in DDD (defined daily dose), as DID (DDD/1000 inhabitants/day) and as DSD (DDD/km2). The prevalence of antibiotic-resistant Escherichia coli and enterococci was determined in faecal samples of healthy volunteers. In both Newfoundland (28 DID) and Greece (29 DID) the overall consumption of antibiotics was more than three times higher compared with that of The Netherlands (9 DID). The lowest prevalence of resistant E. coli against the majority of antibiotics tested was found for the samples from Newfoundland and was significant (P< 0.05) for cefazolin, oxytetracycline and trimethoprim. A poor correlation between the number of DID and the prevalence of resistance was observed [the Pearson correlation coefficient (Pcc) ranged between -0.93 and 0.87]. However, when population density was taken into consideration and antibiotic consumption was expressed in DSD, a strong correlation was observed (and Pcc ranged between 0.86 and 1.00). This study suggests that population density is an important factor in the development of antibiotic resistance and warrants special attention as a factor in resistance epidemiology. Article in Journal/Newspaper Newfoundland Pergamos - Library and Information Center of National and Kapodistrian University of Athens Canada |
institution |
Open Polar |
collection |
Pergamos - Library and Information Center of National and Kapodistrian University of Athens |
op_collection_id |
ftnkunivathens |
language |
English |
description |
Antibiotic consumption and population density as a measure of crowding in the community were related to the prevalence of antibiotic resistance of three cities in three different countries: St Johns in Newfoundland (Canada), Athens in Greece and Groningen in The Netherlands. Antibiotic consumption was expressed in DDD (defined daily dose), as DID (DDD/1000 inhabitants/day) and as DSD (DDD/km2). The prevalence of antibiotic-resistant Escherichia coli and enterococci was determined in faecal samples of healthy volunteers. In both Newfoundland (28 DID) and Greece (29 DID) the overall consumption of antibiotics was more than three times higher compared with that of The Netherlands (9 DID). The lowest prevalence of resistant E. coli against the majority of antibiotics tested was found for the samples from Newfoundland and was significant (P< 0.05) for cefazolin, oxytetracycline and trimethoprim. A poor correlation between the number of DID and the prevalence of resistance was observed [the Pearson correlation coefficient (Pcc) ranged between -0.93 and 0.87]. However, when population density was taken into consideration and antibiotic consumption was expressed in DSD, a strong correlation was observed (and Pcc ranged between 0.86 and 1.00). This study suggests that population density is an important factor in the development of antibiotic resistance and warrants special attention as a factor in resistance epidemiology. |
format |
Article in Journal/Newspaper |
author |
Bruinsma, N. Hutchinson, J.M. van den Bogaard, A.E. Giamarellou, H. Degener, J. Stobberingh, E.E. |
spellingShingle |
Bruinsma, N. Hutchinson, J.M. van den Bogaard, A.E. Giamarellou, H. Degener, J. Stobberingh, E.E. Influence of population density on antibiotic resistance |
author_facet |
Bruinsma, N. Hutchinson, J.M. van den Bogaard, A.E. Giamarellou, H. Degener, J. Stobberingh, E.E. |
author_sort |
Bruinsma, N. |
title |
Influence of population density on antibiotic resistance |
title_short |
Influence of population density on antibiotic resistance |
title_full |
Influence of population density on antibiotic resistance |
title_fullStr |
Influence of population density on antibiotic resistance |
title_full_unstemmed |
Influence of population density on antibiotic resistance |
title_sort |
influence of population density on antibiotic resistance |
publishDate |
2003 |
url |
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3022823 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
uoadl:3022823 https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3022823 |
_version_ |
1790603284078133248 |