Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): Correlation with platelet-activating factor and atherogenesis
Cod (Gadus morhua) is a popular part of the diet in many countries on both sides of the North Atlantic; in most cases it is consumed fried. In this study, total lipids of cod muscle were separated into neutral and polar lipids, which were further fractionated by HPLC. The lipid fractions were tested...
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ftnkunivathens:oai:lib.uoa.gr:uoadl:3011136 2024-02-11T10:03:55+01:00 Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): Correlation with platelet-activating factor and atherogenesis Panayiotou, A. Samartzis, D. Nomikos, T. Fragopoulou, E. Karantonis, H.C. Demopoulos, C.A. Zabetakis, I. 2000-01-01 https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3011136 Αγγλικά English eng uoadl:3011136 https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3011136 scientific_publication_article Επιστημονική δημοσίευση - Άρθρο Περιοδικού Scientific publication - Journal Article 2000 ftnkunivathens 2024-01-18T18:40:48Z Cod (Gadus morhua) is a popular part of the diet in many countries on both sides of the North Atlantic; in most cases it is consumed fried. In this study, total lipids of cod muscle were separated into neutral and polar lipids, which were further fractionated by HPLC. The lipid fractions were tested in vitro, against washed rabbit platelets, for the probable existence of lipid compounds that either exhibit an action similar to that of platelet-activating factor (PAF) or inhibit the action of PAF. The platelet bioassay was used to evaluate total lipids, total polar lipids, and total neutral lipids, before any further separation. Detection of these compounds in fresh and fried cod could be used to evaluate the nutritional value of this important fish. The in vitro biological study of lipids showed that in fresh cod lipid fractions, ranges of PAF-like and anti-PAF-like activities were present, whereas in fried cod lipid fractions, both neutral and polar, anti-PAF activities were mainly observed. Because it has already been reported that PAF is involved in atheromatosis generation, the existence of PAF inhibitors in cod may contribute to the possible protective role of fish, in this case cod, against atherosclerosis. Article in Journal/Newspaper Gadus morhua North Atlantic Pergamos - Library and Information Center of National and Kapodistrian University of Athens |
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Open Polar |
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Pergamos - Library and Information Center of National and Kapodistrian University of Athens |
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ftnkunivathens |
language |
English |
description |
Cod (Gadus morhua) is a popular part of the diet in many countries on both sides of the North Atlantic; in most cases it is consumed fried. In this study, total lipids of cod muscle were separated into neutral and polar lipids, which were further fractionated by HPLC. The lipid fractions were tested in vitro, against washed rabbit platelets, for the probable existence of lipid compounds that either exhibit an action similar to that of platelet-activating factor (PAF) or inhibit the action of PAF. The platelet bioassay was used to evaluate total lipids, total polar lipids, and total neutral lipids, before any further separation. Detection of these compounds in fresh and fried cod could be used to evaluate the nutritional value of this important fish. The in vitro biological study of lipids showed that in fresh cod lipid fractions, ranges of PAF-like and anti-PAF-like activities were present, whereas in fried cod lipid fractions, both neutral and polar, anti-PAF activities were mainly observed. Because it has already been reported that PAF is involved in atheromatosis generation, the existence of PAF inhibitors in cod may contribute to the possible protective role of fish, in this case cod, against atherosclerosis. |
format |
Article in Journal/Newspaper |
author |
Panayiotou, A. Samartzis, D. Nomikos, T. Fragopoulou, E. Karantonis, H.C. Demopoulos, C.A. Zabetakis, I. |
spellingShingle |
Panayiotou, A. Samartzis, D. Nomikos, T. Fragopoulou, E. Karantonis, H.C. Demopoulos, C.A. Zabetakis, I. Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): Correlation with platelet-activating factor and atherogenesis |
author_facet |
Panayiotou, A. Samartzis, D. Nomikos, T. Fragopoulou, E. Karantonis, H.C. Demopoulos, C.A. Zabetakis, I. |
author_sort |
Panayiotou, A. |
title |
Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): Correlation with platelet-activating factor and atherogenesis |
title_short |
Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): Correlation with platelet-activating factor and atherogenesis |
title_full |
Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): Correlation with platelet-activating factor and atherogenesis |
title_fullStr |
Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): Correlation with platelet-activating factor and atherogenesis |
title_full_unstemmed |
Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): Correlation with platelet-activating factor and atherogenesis |
title_sort |
lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (gadus morhua): correlation with platelet-activating factor and atherogenesis |
publishDate |
2000 |
url |
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3011136 |
genre |
Gadus morhua North Atlantic |
genre_facet |
Gadus morhua North Atlantic |
op_relation |
uoadl:3011136 https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3011136 |
_version_ |
1790600294302744576 |