Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology
Background: Discovered and described 40 years ago, non-specific lipid transfer proteins (nsLTP) are present in many plant species and play an important role protecting plants from stressors such as heat or drought. In the last 20 years, sensitization to nsLTP and consequent reactions to plant foods...
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ftnkunivathens:oai:lib.uoa.gr:uoadl:2999878 2024-02-11T10:06:46+01:00 Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology Skypala, I.J. Asero, R. Barber, D. Cecchi, L. Diaz Perales, A. Hoffmann-Sommergruber, K. Pastorello, E.A. Swoboda, I. Bartra, J. Ebo, D.G. Faber, M.A. Fernández-Rivas, M. Gomez, F. Konstantinopoulos, A.P. Luengo, O. van Ree, R. Scala, E. Till, S.J. European Academy of Allergy Clinical Immunology (EAACI) Task Force: Non-specific Lipid Transfer Protein Allergy Across Europe 2021-01-01 https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2999878 Αγγλικά English eng uoadl:2999878 https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2999878 scientific_publication_article Επιστημονική δημοσίευση - Άρθρο Περιοδικού Scientific publication - Journal Article 2021 ftnkunivathens 2024-01-18T19:01:32Z Background: Discovered and described 40 years ago, non-specific lipid transfer proteins (nsLTP) are present in many plant species and play an important role protecting plants from stressors such as heat or drought. In the last 20 years, sensitization to nsLTP and consequent reactions to plant foods has become an increasing concern. Aim: The aim of this paper is to review the evidence for the structure and function of nsLTP allergens, and cross-reactivity, sensitization, and epidemiology of nsLTP allergy. Materials and Methods: A Task Force, supported by the European Academy of Allergy & Clinical Immunology (EAACI), reviewed current evidence and provide a signpost for future research. The search terms for this paper were “Non-specific Lipid Transfer Proteins”, “LTP syndrome”, “Pru p 3”, “plant food allergy”, “pollen-food syndrome”. Results: Most nsLTP allergens have a highly conserved structure stabilised by 4-disulphide bridges. Studies on the peach nsLTP, Pru p 3, demonstrate that nsLTPs are very cross-reactive, with the four major IgE epitopes of Pru p 3 being shared by nsLTP from other botanically related fruits. These nsLTP allergens are to varying degrees resistant to heat and digestion, and sensitization may occur through the oral, inhaled or cutaneous routes. In some populations, Pru p 3 is the primary and sole sensitizing allergen, but many are poly-sensitised both to botanically un-related nsLTP in foods, and non-food sources of nsLTP such as Cannabis sativa, Platanus acerifolia, (plane tree), Ambrosia artemisiifolia (ragweed) and Artemisia vulgaris (mugwort). Initially, nsLTP sensitization appeared to be limited to Mediterranean countries, however more recent studies suggest clinically relevant sensitization occurs in North Atlantic regions and also countries in Northern Europe, with nsLTP sensitisation profiles being broadly similar. Discussion: These robust allergens have the potential to sensitize and provoke symptoms to a large number of plant foods, including those which are raw, cooked or ... Article in Journal/Newspaper North Atlantic Pergamos - Library and Information Center of National and Kapodistrian University of Athens |
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Pergamos - Library and Information Center of National and Kapodistrian University of Athens |
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ftnkunivathens |
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English |
description |
Background: Discovered and described 40 years ago, non-specific lipid transfer proteins (nsLTP) are present in many plant species and play an important role protecting plants from stressors such as heat or drought. In the last 20 years, sensitization to nsLTP and consequent reactions to plant foods has become an increasing concern. Aim: The aim of this paper is to review the evidence for the structure and function of nsLTP allergens, and cross-reactivity, sensitization, and epidemiology of nsLTP allergy. Materials and Methods: A Task Force, supported by the European Academy of Allergy & Clinical Immunology (EAACI), reviewed current evidence and provide a signpost for future research. The search terms for this paper were “Non-specific Lipid Transfer Proteins”, “LTP syndrome”, “Pru p 3”, “plant food allergy”, “pollen-food syndrome”. Results: Most nsLTP allergens have a highly conserved structure stabilised by 4-disulphide bridges. Studies on the peach nsLTP, Pru p 3, demonstrate that nsLTPs are very cross-reactive, with the four major IgE epitopes of Pru p 3 being shared by nsLTP from other botanically related fruits. These nsLTP allergens are to varying degrees resistant to heat and digestion, and sensitization may occur through the oral, inhaled or cutaneous routes. In some populations, Pru p 3 is the primary and sole sensitizing allergen, but many are poly-sensitised both to botanically un-related nsLTP in foods, and non-food sources of nsLTP such as Cannabis sativa, Platanus acerifolia, (plane tree), Ambrosia artemisiifolia (ragweed) and Artemisia vulgaris (mugwort). Initially, nsLTP sensitization appeared to be limited to Mediterranean countries, however more recent studies suggest clinically relevant sensitization occurs in North Atlantic regions and also countries in Northern Europe, with nsLTP sensitisation profiles being broadly similar. Discussion: These robust allergens have the potential to sensitize and provoke symptoms to a large number of plant foods, including those which are raw, cooked or ... |
format |
Article in Journal/Newspaper |
author |
Skypala, I.J. Asero, R. Barber, D. Cecchi, L. Diaz Perales, A. Hoffmann-Sommergruber, K. Pastorello, E.A. Swoboda, I. Bartra, J. Ebo, D.G. Faber, M.A. Fernández-Rivas, M. Gomez, F. Konstantinopoulos, A.P. Luengo, O. van Ree, R. Scala, E. Till, S.J. European Academy of Allergy Clinical Immunology (EAACI) Task Force: Non-specific Lipid Transfer Protein Allergy Across Europe |
spellingShingle |
Skypala, I.J. Asero, R. Barber, D. Cecchi, L. Diaz Perales, A. Hoffmann-Sommergruber, K. Pastorello, E.A. Swoboda, I. Bartra, J. Ebo, D.G. Faber, M.A. Fernández-Rivas, M. Gomez, F. Konstantinopoulos, A.P. Luengo, O. van Ree, R. Scala, E. Till, S.J. European Academy of Allergy Clinical Immunology (EAACI) Task Force: Non-specific Lipid Transfer Protein Allergy Across Europe Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
author_facet |
Skypala, I.J. Asero, R. Barber, D. Cecchi, L. Diaz Perales, A. Hoffmann-Sommergruber, K. Pastorello, E.A. Swoboda, I. Bartra, J. Ebo, D.G. Faber, M.A. Fernández-Rivas, M. Gomez, F. Konstantinopoulos, A.P. Luengo, O. van Ree, R. Scala, E. Till, S.J. European Academy of Allergy Clinical Immunology (EAACI) Task Force: Non-specific Lipid Transfer Protein Allergy Across Europe |
author_sort |
Skypala, I.J. |
title |
Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
title_short |
Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
title_full |
Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
title_fullStr |
Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
title_full_unstemmed |
Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
title_sort |
non-specific lipid-transfer proteins: allergen structure and function, cross-reactivity, sensitization, and epidemiology |
publishDate |
2021 |
url |
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2999878 |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_relation |
uoadl:2999878 https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2999878 |
_version_ |
1790604685727498240 |