Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids

Novel silybin acylated derivatives with dicarboxylic acids were prepared in various organic solvents using immobilized Candida antarctica lipase B (Novozym 435 ®). The reaction parameters affecting the silybin conversion, such as the nature of the organic solvent and the acyl donor used were investi...

Full description

Bibliographic Details
Main Authors: Theodosiou, E., Loutrari, H., Stamatis, H., Roussos, C., Kolisis, F.N.
Format: Article in Journal/Newspaper
Language:unknown
English
Published: 2011
Subjects:
Antarc*
Antarctica
Online Access:https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2981635
id ftnkunivathens:oai:lib.uoa.gr:uoadl:2981635
record_format openpolar
spelling ftnkunivathens:oai:lib.uoa.gr:uoadl:2981635 2024-04-14T08:04:41+00:00 Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids Theodosiou, E. Loutrari, H. Stamatis, H. Roussos, C. Kolisis, F.N. 2011-01-01 https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2981635 Αγγλικά English unknown eng uoadl:2981635 https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2981635 scientific_publication_article Επιστημονική δημοσίευση - Άρθρο Περιοδικού Scientific publication - Journal Article 2011 ftnkunivathens 2024-03-19T08:51:29Z Novel silybin acylated derivatives with dicarboxylic acids were prepared in various organic solvents using immobilized Candida antarctica lipase B (Novozym 435 ®). The reaction parameters affecting the silybin conversion, such as the nature of the organic solvent and the acyl donor used were investigated. The antiproliferative effects of silybin monoesters, and their ability to modulate the secretion of vascular endothelial growth factor (VEGF) were estimated using K562 human lymphoblastoma cells and compared to the parental compound. The synthesized esters retained the biological function of silybin and in some cases were more effective, indicating that target biotransformation may generate novel compounds with improved antitumor and antiangiogenic activities. © 2011 Elsevier B.V. Article in Journal/Newspaper Antarc* Antarctica Pergamos - Library and Information Center of National and Kapodistrian University of Athens
institution Open Polar
collection Pergamos - Library and Information Center of National and Kapodistrian University of Athens
op_collection_id ftnkunivathens
language unknown
English
description Novel silybin acylated derivatives with dicarboxylic acids were prepared in various organic solvents using immobilized Candida antarctica lipase B (Novozym 435 ®). The reaction parameters affecting the silybin conversion, such as the nature of the organic solvent and the acyl donor used were investigated. The antiproliferative effects of silybin monoesters, and their ability to modulate the secretion of vascular endothelial growth factor (VEGF) were estimated using K562 human lymphoblastoma cells and compared to the parental compound. The synthesized esters retained the biological function of silybin and in some cases were more effective, indicating that target biotransformation may generate novel compounds with improved antitumor and antiangiogenic activities. © 2011 Elsevier B.V.
format Article in Journal/Newspaper
author Theodosiou, E.
Loutrari, H.
Stamatis, H.
Roussos, C.
Kolisis, F.N.
spellingShingle Theodosiou, E.
Loutrari, H.
Stamatis, H.
Roussos, C.
Kolisis, F.N.
Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids
author_facet Theodosiou, E.
Loutrari, H.
Stamatis, H.
Roussos, C.
Kolisis, F.N.
author_sort Theodosiou, E.
title Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids
title_short Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids
title_full Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids
title_fullStr Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids
title_full_unstemmed Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids
title_sort biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids
publishDate 2011
url https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2981635
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_relation uoadl:2981635
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2981635
_version_ 1796301385989357568

Similar Items