Investigation of complement system activation and regulation during Indian Antarctic expedition
Antarctica is one of the most effective sites to measure the impact of human isolation, sleep deprivation, light-dark period and harsh environmental conditions. In the present study we address several aspects of the activation and regulation of the complement system. Alterations in the body systems...
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ftnipr:oai:nipr.repo.nii.ac.jp:00016840 2023-05-15T13:49:00+02:00 Investigation of complement system activation and regulation during Indian Antarctic expedition 2021-09 https://nipr.repo.nii.ac.jp/?action=repository_uri&item_id=16840 http://id.nii.ac.jp/1291/00016710/ en eng https://doi.org/10.1016/j.polar.2021.100699 https://nipr.repo.nii.ac.jp/?action=repository_uri&item_id=16840 http://id.nii.ac.jp/1291/00016710/ Polar Science, 29, 100699(2021-09) 18739652 Antarctic stress Complement activation Anaphylatoxin Complement regulators Journal Article 2021 ftnipr https://doi.org/10.1016/j.polar.2021.100699 2022-12-03T19:43:21Z Antarctica is one of the most effective sites to measure the impact of human isolation, sleep deprivation, light-dark period and harsh environmental conditions. In the present study we address several aspects of the activation and regulation of the complement system. Alterations in the body systems mainly related to immunology, physiology and psychology, during expeditions to the Antarctica, leads to various complexities. In the present study the research findings are based on two group members from 34th Indian Scientific Expedition to the Antarctic. The first group-included members from “summer” expedition, while the second group-included members subjected to the Antarctic environment for the “winter” expedition. Blood samples were collected from both the groups and evaluated for various activation and regulatory complement protein. Serum levels of C3, C4 & C5a were analysed. Anaphylatoxin C3a was up regulated significantly in both the teams. However, C5a, another anaphylatoxin was also increased in both teams though not significantly during winter expedition. Complement regulatory proteins C1- Inhibitor, Factor D, Factor H were unregulated significantly during summer and winter exposures. However, Factor D levels increased significantly only in the month of April (W2) of summer exposure. Thus, this indicates that harsh Antarctic conditions could be detrimental factor for activation of complement system in both the teams. However, the effect of activated complement system during the expedition was regulated in positive manner and could not be correlated with clinical manifestations due to the multiple stressors and small population size during Antarctic expedition. Article in Journal/Newspaper Antarc* Antarctic Antarctica Polar Science Polar Science National Institute of Polar Research Repository, Japan Antarctic The Antarctic Indian Polar Science 29 100699 |
institution |
Open Polar |
collection |
National Institute of Polar Research Repository, Japan |
op_collection_id |
ftnipr |
language |
English |
topic |
Antarctic stress Complement activation Anaphylatoxin Complement regulators |
spellingShingle |
Antarctic stress Complement activation Anaphylatoxin Complement regulators Investigation of complement system activation and regulation during Indian Antarctic expedition |
topic_facet |
Antarctic stress Complement activation Anaphylatoxin Complement regulators |
description |
Antarctica is one of the most effective sites to measure the impact of human isolation, sleep deprivation, light-dark period and harsh environmental conditions. In the present study we address several aspects of the activation and regulation of the complement system. Alterations in the body systems mainly related to immunology, physiology and psychology, during expeditions to the Antarctica, leads to various complexities. In the present study the research findings are based on two group members from 34th Indian Scientific Expedition to the Antarctic. The first group-included members from “summer” expedition, while the second group-included members subjected to the Antarctic environment for the “winter” expedition. Blood samples were collected from both the groups and evaluated for various activation and regulatory complement protein. Serum levels of C3, C4 & C5a were analysed. Anaphylatoxin C3a was up regulated significantly in both the teams. However, C5a, another anaphylatoxin was also increased in both teams though not significantly during winter expedition. Complement regulatory proteins C1- Inhibitor, Factor D, Factor H were unregulated significantly during summer and winter exposures. However, Factor D levels increased significantly only in the month of April (W2) of summer exposure. Thus, this indicates that harsh Antarctic conditions could be detrimental factor for activation of complement system in both the teams. However, the effect of activated complement system during the expedition was regulated in positive manner and could not be correlated with clinical manifestations due to the multiple stressors and small population size during Antarctic expedition. |
format |
Article in Journal/Newspaper |
title |
Investigation of complement system activation and regulation during Indian Antarctic expedition |
title_short |
Investigation of complement system activation and regulation during Indian Antarctic expedition |
title_full |
Investigation of complement system activation and regulation during Indian Antarctic expedition |
title_fullStr |
Investigation of complement system activation and regulation during Indian Antarctic expedition |
title_full_unstemmed |
Investigation of complement system activation and regulation during Indian Antarctic expedition |
title_sort |
investigation of complement system activation and regulation during indian antarctic expedition |
publishDate |
2021 |
url |
https://nipr.repo.nii.ac.jp/?action=repository_uri&item_id=16840 http://id.nii.ac.jp/1291/00016710/ |
geographic |
Antarctic The Antarctic Indian |
geographic_facet |
Antarctic The Antarctic Indian |
genre |
Antarc* Antarctic Antarctica Polar Science Polar Science |
genre_facet |
Antarc* Antarctic Antarctica Polar Science Polar Science |
op_relation |
https://doi.org/10.1016/j.polar.2021.100699 https://nipr.repo.nii.ac.jp/?action=repository_uri&item_id=16840 http://id.nii.ac.jp/1291/00016710/ Polar Science, 29, 100699(2021-09) 18739652 |
op_doi |
https://doi.org/10.1016/j.polar.2021.100699 |
container_title |
Polar Science |
container_volume |
29 |
container_start_page |
100699 |
_version_ |
1766250398178344960 |