Potential natural immunization against atherosclerosis in hibernating bears
Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney insufciency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated...
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ftninstnf:oai:brage.nina.no:11250/2759886 2024-06-23T07:57:22+00:00 Potential natural immunization against atherosclerosis in hibernating bears Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan Sverige 2021 application/pdf https://hdl.handle.net/11250/2759886 https://doi.org/10.1038/s41598/s41598-021-91679-1 eng eng Andre: Swedish Research Council Andre: INTRICARE Marie Skłodowska Curie Grant Number 722609 Andre: Swedish Heart Lung Foundation Andre: King Gustav V 80th Birthday Fund Andre: Swedish Association against Rheumatism Andre: CIMED Andre: Stockholm County urn:issn:2045-2322 https://hdl.handle.net/11250/2759886 https://doi.org/10.1038/s41598/s41598-021-91679-1 cristin:1916025 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no © The Author(s) 2021 11 Scientific Reports 12120 VDP::Zoologiske og botaniske fag: 480 VDP::Zoology and botany: 480 Peer reviewed Journal article 2021 ftninstnf https://doi.org/10.1038/s41598/s41598-021-91679-1 2024-06-07T03:57:56Z Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney insufciency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have antiinfammatory and other potentially protective properties. PC but not MDA is exposed on diferent types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), signifcantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the diference was striking; 100 IQR (85.9–107.9) vs 782.3, IQR (422.8–1586.0; p < 0.001). In contrast, subclasses and isotypes of anti-MDA were signifcantly lower in winter except IgA anti-MDA, which was not detectable. Anti-PCs are signifcantly raised during hibernation in brown bears; especially IgA anti-PC was strikingly high. In contrast, anti-MDA titers was decreased during hibernation. Our observation may represent natural immunization with microorganisms during a vulnerable period and could have therapeutic implications for prevention of atherosclerosis. publishedVersion Article in Journal/Newspaper Ursus arctos Norwegian Institute for Nature Research: Brage NINA |
institution |
Open Polar |
collection |
Norwegian Institute for Nature Research: Brage NINA |
op_collection_id |
ftninstnf |
language |
English |
topic |
VDP::Zoologiske og botaniske fag: 480 VDP::Zoology and botany: 480 |
spellingShingle |
VDP::Zoologiske og botaniske fag: 480 VDP::Zoology and botany: 480 Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan Potential natural immunization against atherosclerosis in hibernating bears |
topic_facet |
VDP::Zoologiske og botaniske fag: 480 VDP::Zoology and botany: 480 |
description |
Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney insufciency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have antiinfammatory and other potentially protective properties. PC but not MDA is exposed on diferent types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), signifcantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the diference was striking; 100 IQR (85.9–107.9) vs 782.3, IQR (422.8–1586.0; p < 0.001). In contrast, subclasses and isotypes of anti-MDA were signifcantly lower in winter except IgA anti-MDA, which was not detectable. Anti-PCs are signifcantly raised during hibernation in brown bears; especially IgA anti-PC was strikingly high. In contrast, anti-MDA titers was decreased during hibernation. Our observation may represent natural immunization with microorganisms during a vulnerable period and could have therapeutic implications for prevention of atherosclerosis. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan |
author_facet |
Samal, Shailesh Kumar Fröbert, Ole Kindberg, Jonas Stenvinkel, Peter Frostegård, Johan |
author_sort |
Samal, Shailesh Kumar |
title |
Potential natural immunization against atherosclerosis in hibernating bears |
title_short |
Potential natural immunization against atherosclerosis in hibernating bears |
title_full |
Potential natural immunization against atherosclerosis in hibernating bears |
title_fullStr |
Potential natural immunization against atherosclerosis in hibernating bears |
title_full_unstemmed |
Potential natural immunization against atherosclerosis in hibernating bears |
title_sort |
potential natural immunization against atherosclerosis in hibernating bears |
publishDate |
2021 |
url |
https://hdl.handle.net/11250/2759886 https://doi.org/10.1038/s41598/s41598-021-91679-1 |
op_coverage |
Sverige |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
11 Scientific Reports 12120 |
op_relation |
Andre: Swedish Research Council Andre: INTRICARE Marie Skłodowska Curie Grant Number 722609 Andre: Swedish Heart Lung Foundation Andre: King Gustav V 80th Birthday Fund Andre: Swedish Association against Rheumatism Andre: CIMED Andre: Stockholm County urn:issn:2045-2322 https://hdl.handle.net/11250/2759886 https://doi.org/10.1038/s41598/s41598-021-91679-1 cristin:1916025 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no © The Author(s) 2021 |
op_doi |
https://doi.org/10.1038/s41598/s41598-021-91679-1 |
_version_ |
1802650969181257728 |