Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions
Background: Longitudinal monitoring studies of persistent organic pollutants (POPs) in human populations are important to better understand changes with time and age, and for future predictions. Objectives: We sought to describe serum POP time trends on an individual level, investigate age–period–co...
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Online Access: | http://hdl.handle.net/11250/275480 https://doi.org/10.1289/ehp.1206317 |
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ftnilu:oai:nilu.brage.unit.no:11250/275480 2023-07-30T04:05:51+02:00 Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions Nøst, Therese Haugdahl Breivik, Knut Fuskevåg, Ole-Martin Nieboer, Evert Odland, Jon Øyvind Sandanger, Torkjel M 2015-01-21T12:26:57Z application/pdf http://hdl.handle.net/11250/275480 https://doi.org/10.1289/ehp.1206317 eng eng Norges forskningsråd: 196191 Nøst, T.H., Breivik, K., Fuskevåg, O.-M., Nieboer, E., Odland, J.Ø., Sandanger, T.M. (2013) Persistent organic pollutants in Norwegian men from 1979 to 2007: Intraindividual changes, age-period-cohort effects, and model predictions. Environ. Health Perspect., 121, 1292-1298. doi:10.1289/ehp.1206317. urn:issn:0091-6765 http://hdl.handle.net/11250/275480 https://doi.org/10.1289/ehp.1206317 cristin:1072176 1292-1298 121 Environmental Health Perspectives 11-12 Journal article Peer reviewed 2015 ftnilu https://doi.org/10.1289/ehp.1206317 2023-07-08T19:53:52Z Background: Longitudinal monitoring studies of persistent organic pollutants (POPs) in human populations are important to better understand changes with time and age, and for future predictions. Objectives: We sought to describe serum POP time trends on an individual level, investigate age–period–cohort effects, and compare predicted polychlorinated biphenyl (PCB) concentrations to measured values. Methods: Serum was sampled in 1979, 1986, 1994, 2001, and 2007 from a cohort of 53 men in Northern Norway and analyzed for 41 POPs. Time period, age, and birth cohort effects were assessed by graphical analyses and mixed-effect models. We derived the predicted concentrations of four PCBs for each sampling year using the CoZMoMAN model. Results: The median decreases in summed serum POP concentrations (lipid-adjusted) in 1986, 1994, 2001, and 2007 relative to 1979 were –22%, –52%, –54%, and –68%, respectively. We observed substantial declines in all POP groups with the exception of chlordanes. Time period (reflected by sampling year) was the strongest descriptor of changes in PCB-153 concentrations. Predicted PCB-153 concentrations were consistent with measured concentrations in the study population. Conclusions: Our results suggest substantial intraindividual declines in serum concentrations of legacy POPs from 1979 to 2007 in men from Northern Norway. These changes are consistent with reduced environmental exposure during these 30 years and highlight the relation between historic emissions and POP concentrations measured in humans. Observed data and interpretations are supported by estimates from the CoZMoMAN emission-based model. A longitudinal decrease in concentrations with age was evident for all birth cohorts. Overall, our findings support the relevance of age–period–cohort effects to human biomonitoring of environmental contaminants. Article in Journal/Newspaper Northern Norway NILU – Norwegian Institute for Air Research: NILU Brage Norway Environmental Health Perspectives 121 11-12 1292 1298 |
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Open Polar |
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NILU – Norwegian Institute for Air Research: NILU Brage |
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ftnilu |
language |
English |
description |
Background: Longitudinal monitoring studies of persistent organic pollutants (POPs) in human populations are important to better understand changes with time and age, and for future predictions. Objectives: We sought to describe serum POP time trends on an individual level, investigate age–period–cohort effects, and compare predicted polychlorinated biphenyl (PCB) concentrations to measured values. Methods: Serum was sampled in 1979, 1986, 1994, 2001, and 2007 from a cohort of 53 men in Northern Norway and analyzed for 41 POPs. Time period, age, and birth cohort effects were assessed by graphical analyses and mixed-effect models. We derived the predicted concentrations of four PCBs for each sampling year using the CoZMoMAN model. Results: The median decreases in summed serum POP concentrations (lipid-adjusted) in 1986, 1994, 2001, and 2007 relative to 1979 were –22%, –52%, –54%, and –68%, respectively. We observed substantial declines in all POP groups with the exception of chlordanes. Time period (reflected by sampling year) was the strongest descriptor of changes in PCB-153 concentrations. Predicted PCB-153 concentrations were consistent with measured concentrations in the study population. Conclusions: Our results suggest substantial intraindividual declines in serum concentrations of legacy POPs from 1979 to 2007 in men from Northern Norway. These changes are consistent with reduced environmental exposure during these 30 years and highlight the relation between historic emissions and POP concentrations measured in humans. Observed data and interpretations are supported by estimates from the CoZMoMAN emission-based model. A longitudinal decrease in concentrations with age was evident for all birth cohorts. Overall, our findings support the relevance of age–period–cohort effects to human biomonitoring of environmental contaminants. |
format |
Article in Journal/Newspaper |
author |
Nøst, Therese Haugdahl Breivik, Knut Fuskevåg, Ole-Martin Nieboer, Evert Odland, Jon Øyvind Sandanger, Torkjel M |
spellingShingle |
Nøst, Therese Haugdahl Breivik, Knut Fuskevåg, Ole-Martin Nieboer, Evert Odland, Jon Øyvind Sandanger, Torkjel M Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
author_facet |
Nøst, Therese Haugdahl Breivik, Knut Fuskevåg, Ole-Martin Nieboer, Evert Odland, Jon Øyvind Sandanger, Torkjel M |
author_sort |
Nøst, Therese Haugdahl |
title |
Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
title_short |
Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
title_full |
Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
title_fullStr |
Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
title_full_unstemmed |
Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
title_sort |
persistent organic pollutants in norwegian men from 1979 to 2007: intraindividual changes, age–period–cohort effects, and model predictions |
publishDate |
2015 |
url |
http://hdl.handle.net/11250/275480 https://doi.org/10.1289/ehp.1206317 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Northern Norway |
genre_facet |
Northern Norway |
op_source |
1292-1298 121 Environmental Health Perspectives 11-12 |
op_relation |
Norges forskningsråd: 196191 Nøst, T.H., Breivik, K., Fuskevåg, O.-M., Nieboer, E., Odland, J.Ø., Sandanger, T.M. (2013) Persistent organic pollutants in Norwegian men from 1979 to 2007: Intraindividual changes, age-period-cohort effects, and model predictions. Environ. Health Perspect., 121, 1292-1298. doi:10.1289/ehp.1206317. urn:issn:0091-6765 http://hdl.handle.net/11250/275480 https://doi.org/10.1289/ehp.1206317 cristin:1072176 |
op_doi |
https://doi.org/10.1289/ehp.1206317 |
container_title |
Environmental Health Perspectives |
container_volume |
121 |
container_issue |
11-12 |
container_start_page |
1292 |
op_container_end_page |
1298 |
_version_ |
1772818125817905152 |