Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator
Environmental factors that can influence telomeres are diverse, but the association between telomeres and exposure to environmental contaminants is yet to be elucidated. To date, prior studies have focused on legacy persistent chlorinated pollutants (POPs), while the effects of poly- and perfluoroal...
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Online Access: | https://hdl.handle.net/11250/2729470 https://doi.org/10.1021/acs.est.0c03099 |
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ftnilu:oai:nilu.brage.unit.no:11250/2729470 2023-07-30T04:01:35+02:00 Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator Sebastiano, Manrico Angelier, Frédéric Blévin, Pierre Ribout, Cécile Sagerup, Kjetil Descamps, Sebastien Herzke, Dorte Moe, Børge Barbarud, Christophe Bustnes, Jan Ove Gabrielsen, Geir W. Chastel, Olivier 2020 application/pdf https://hdl.handle.net/11250/2729470 https://doi.org/10.1021/acs.est.0c03099 eng eng Framsenteret: Flagship Hazardous Substances NILU - Norsk institutt for luftforskning: 114029 NILU - Norsk institutt for luftforskning: 119008 Norges forskningsråd: 287114 Environmental Science and Technology. 2020, 54, 10217-10226. urn:issn:0013-936X https://hdl.handle.net/11250/2729470 https://doi.org/10.1021/acs.est.0c03099 cristin:1822228 Copyright © 2020 American Chemical Society 10217-10226 54 Environmental Science and Technology VDP::Zoologiske og botaniske fag: 480 VDP::Zoology and botany: 480 Peer reviewed Journal article 2020 ftnilu https://doi.org/10.1021/acs.est.0c03099 2023-07-08T19:54:10Z Environmental factors that can influence telomeres are diverse, but the association between telomeres and exposure to environmental contaminants is yet to be elucidated. To date, prior studies have focused on legacy persistent chlorinated pollutants (POPs), while the effects of poly- and perfluoroalkyl substances (PFAS) have been poorly documented. Here, we investigated the associations among PFAS congeners, absolute telomere length (cross-sectional approach), and telomere dynamics (rate of telomere length change over time, longitudinal approach) in one of the most contaminated arctic top predators, the glaucous gull Larus hyperboreus from Svalbard. We further estimated the effect of PFAS on apparent survival rates and re-sighting probabilities using a 10-year capture/recapture dataset (2010–2019). We found that birds exposed to higher concentrations of perfluorononadecanoate (PFNA) (median of 1565 pg/mL of ww in males and 1370 pg/mL of ww in females) and perfluorotetradecanoate (PFTeDA) (median of 370 pg/mL of ww in males and 210 pg/mL of ww in females) showed the slowest rate of telomere shortening. We also found that high blood concentrations of perfluorooctanoate (PFOA) (median of 120 pg/mL of ww in males and 150 pg/mL of ww in females) and perfluorohexanesulfonate (PFHxS) (median of 495 pg/mL of ww in males and 395 pg/mL of ww in females) were positively associated with higher re-sighting probabilities and apparent survival in males but not in females. Our work is the first to report an association between single PFAS compounds and telomeres, and the first to link PFAS exposure with survival probabilities, suggesting that the effect of PFAS exposure might be more tied to the type of compound rather than the total concentration of PFAS. acceptedVersion Article in Journal/Newspaper Arctic Glaucous Gull Larus hyperboreus Svalbard NILU – Norwegian Institute for Air Research: NILU Brage Arctic Svalbard Environmental Science & Technology 54 16 10217 10226 |
institution |
Open Polar |
collection |
NILU – Norwegian Institute for Air Research: NILU Brage |
op_collection_id |
ftnilu |
language |
English |
topic |
VDP::Zoologiske og botaniske fag: 480 VDP::Zoology and botany: 480 |
spellingShingle |
VDP::Zoologiske og botaniske fag: 480 VDP::Zoology and botany: 480 Sebastiano, Manrico Angelier, Frédéric Blévin, Pierre Ribout, Cécile Sagerup, Kjetil Descamps, Sebastien Herzke, Dorte Moe, Børge Barbarud, Christophe Bustnes, Jan Ove Gabrielsen, Geir W. Chastel, Olivier Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
topic_facet |
VDP::Zoologiske og botaniske fag: 480 VDP::Zoology and botany: 480 |
description |
Environmental factors that can influence telomeres are diverse, but the association between telomeres and exposure to environmental contaminants is yet to be elucidated. To date, prior studies have focused on legacy persistent chlorinated pollutants (POPs), while the effects of poly- and perfluoroalkyl substances (PFAS) have been poorly documented. Here, we investigated the associations among PFAS congeners, absolute telomere length (cross-sectional approach), and telomere dynamics (rate of telomere length change over time, longitudinal approach) in one of the most contaminated arctic top predators, the glaucous gull Larus hyperboreus from Svalbard. We further estimated the effect of PFAS on apparent survival rates and re-sighting probabilities using a 10-year capture/recapture dataset (2010–2019). We found that birds exposed to higher concentrations of perfluorononadecanoate (PFNA) (median of 1565 pg/mL of ww in males and 1370 pg/mL of ww in females) and perfluorotetradecanoate (PFTeDA) (median of 370 pg/mL of ww in males and 210 pg/mL of ww in females) showed the slowest rate of telomere shortening. We also found that high blood concentrations of perfluorooctanoate (PFOA) (median of 120 pg/mL of ww in males and 150 pg/mL of ww in females) and perfluorohexanesulfonate (PFHxS) (median of 495 pg/mL of ww in males and 395 pg/mL of ww in females) were positively associated with higher re-sighting probabilities and apparent survival in males but not in females. Our work is the first to report an association between single PFAS compounds and telomeres, and the first to link PFAS exposure with survival probabilities, suggesting that the effect of PFAS exposure might be more tied to the type of compound rather than the total concentration of PFAS. acceptedVersion |
format |
Article in Journal/Newspaper |
author |
Sebastiano, Manrico Angelier, Frédéric Blévin, Pierre Ribout, Cécile Sagerup, Kjetil Descamps, Sebastien Herzke, Dorte Moe, Børge Barbarud, Christophe Bustnes, Jan Ove Gabrielsen, Geir W. Chastel, Olivier |
author_facet |
Sebastiano, Manrico Angelier, Frédéric Blévin, Pierre Ribout, Cécile Sagerup, Kjetil Descamps, Sebastien Herzke, Dorte Moe, Børge Barbarud, Christophe Bustnes, Jan Ove Gabrielsen, Geir W. Chastel, Olivier |
author_sort |
Sebastiano, Manrico |
title |
Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
title_short |
Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
title_full |
Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
title_fullStr |
Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
title_full_unstemmed |
Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
title_sort |
exposure to pfas is associated with telomere length dynamics and demographic responses of an arctic top predator |
publishDate |
2020 |
url |
https://hdl.handle.net/11250/2729470 https://doi.org/10.1021/acs.est.0c03099 |
geographic |
Arctic Svalbard |
geographic_facet |
Arctic Svalbard |
genre |
Arctic Glaucous Gull Larus hyperboreus Svalbard |
genre_facet |
Arctic Glaucous Gull Larus hyperboreus Svalbard |
op_source |
10217-10226 54 Environmental Science and Technology |
op_relation |
Framsenteret: Flagship Hazardous Substances NILU - Norsk institutt for luftforskning: 114029 NILU - Norsk institutt for luftforskning: 119008 Norges forskningsråd: 287114 Environmental Science and Technology. 2020, 54, 10217-10226. urn:issn:0013-936X https://hdl.handle.net/11250/2729470 https://doi.org/10.1021/acs.est.0c03099 cristin:1822228 |
op_rights |
Copyright © 2020 American Chemical Society |
op_doi |
https://doi.org/10.1021/acs.est.0c03099 |
container_title |
Environmental Science & Technology |
container_volume |
54 |
container_issue |
16 |
container_start_page |
10217 |
op_container_end_page |
10226 |
_version_ |
1772812363052875776 |