Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring Results
Background: One of the most serious human health concerns related to environmental contamination with polychlorinated biphenyls (PCBs) is the presence of these chemicals in breast milk. Objectives: We developed a physiologically based pharmacokinetic model of PCB-153 in women, and predict its transf...
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US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
2008
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ftnhri:oai:ir.nhri.org.tw:3990099045/3277 2023-07-02T03:32:46+02:00 Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring Results Redding, LE;Sohn, MD;McKone, TE;Chen, JW;Wang, SL;Hsieh, DPH;Yang, RSH Division of Environmental Health and Occupational Medicine 2008-12 application/pdf 166639 bytes http://ir.nhri.org.tw/handle/3990099045/3277 http://ir.nhri.org.tw/bitstream/3990099045/3277/3/SCP58149356242.pdf en-US en_US eng US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE Environmental Health Perspectives. 2008 Dec;116(12):1629-1634. 0091-6765 10.1289/ehp.11519 http://ir.nhri.org.tw/handle/3990099045/3277 http://ir.nhri.org.tw/bitstream/3990099045/3277/3/SCP58149356242.pdf Article 2008 ftnhri 2023-06-13T16:08:14Z Background: One of the most serious human health concerns related to environmental contamination with polychlorinated biphenyls (PCBs) is the presence of these chemicals in breast milk. Objectives: We developed a physiologically based pharmacokinetic model of PCB-153 in women, and predict its transfer via lactation to infants. The model is the first human, population-scale lactational model for PCB-153. Data in the literature provided estimates for model development and for performance assessment. Methods: We used physiologic parameters from a cohort in Taiwan and reference values given in the literature to estimate partition coefficients based on chemical structure and the lipid content in various body tissues. Using exposure data from Japan, we predicted acquired body burden of PCB-153 at an average childbearing age of 25 years and compared predictions to measurements from studies in multiple countries. We attempted one example of reverse dosimetry modeling using our PBPK model for possible exposure scenarios in Canadian Inuits, the population with the highest breast milk PCB-153 level in the world. Results: Forward-model predictions agree well with human biomonitoring measurements, as represented by summary statistics and uncertainty estimates. Conclusion: The model successfully describes the range of possible PCB-153 dispositions in maternal milk, suggesting a promising option for back-estimating doses for various populations. Article in Journal/Newspaper inuits National Health Research Institutes (NHRI): Institutional Repository |
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National Health Research Institutes (NHRI): Institutional Repository |
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English |
description |
Background: One of the most serious human health concerns related to environmental contamination with polychlorinated biphenyls (PCBs) is the presence of these chemicals in breast milk. Objectives: We developed a physiologically based pharmacokinetic model of PCB-153 in women, and predict its transfer via lactation to infants. The model is the first human, population-scale lactational model for PCB-153. Data in the literature provided estimates for model development and for performance assessment. Methods: We used physiologic parameters from a cohort in Taiwan and reference values given in the literature to estimate partition coefficients based on chemical structure and the lipid content in various body tissues. Using exposure data from Japan, we predicted acquired body burden of PCB-153 at an average childbearing age of 25 years and compared predictions to measurements from studies in multiple countries. We attempted one example of reverse dosimetry modeling using our PBPK model for possible exposure scenarios in Canadian Inuits, the population with the highest breast milk PCB-153 level in the world. Results: Forward-model predictions agree well with human biomonitoring measurements, as represented by summary statistics and uncertainty estimates. Conclusion: The model successfully describes the range of possible PCB-153 dispositions in maternal milk, suggesting a promising option for back-estimating doses for various populations. |
author2 |
Division of Environmental Health and Occupational Medicine |
format |
Article in Journal/Newspaper |
author |
Redding, LE;Sohn, MD;McKone, TE;Chen, JW;Wang, SL;Hsieh, DPH;Yang, RSH |
spellingShingle |
Redding, LE;Sohn, MD;McKone, TE;Chen, JW;Wang, SL;Hsieh, DPH;Yang, RSH Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring Results |
author_facet |
Redding, LE;Sohn, MD;McKone, TE;Chen, JW;Wang, SL;Hsieh, DPH;Yang, RSH |
author_sort |
Redding, LE;Sohn, MD;McKone, TE;Chen, JW;Wang, SL;Hsieh, DPH;Yang, RSH |
title |
Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring Results |
title_short |
Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring Results |
title_full |
Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring Results |
title_fullStr |
Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring Results |
title_full_unstemmed |
Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring Results |
title_sort |
population physiologically based pharmacokinetic modeling for the human lactational transfer of pcb-153 with consideration of worldwide human biomonitoring results |
publisher |
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE |
publishDate |
2008 |
url |
http://ir.nhri.org.tw/handle/3990099045/3277 http://ir.nhri.org.tw/bitstream/3990099045/3277/3/SCP58149356242.pdf |
genre |
inuits |
genre_facet |
inuits |
op_relation |
Environmental Health Perspectives. 2008 Dec;116(12):1629-1634. 0091-6765 10.1289/ehp.11519 http://ir.nhri.org.tw/handle/3990099045/3277 http://ir.nhri.org.tw/bitstream/3990099045/3277/3/SCP58149356242.pdf |
_version_ |
1770272449818001408 |