Epstein-Barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland
Undifferentiated nasopharyngeal carcinoma is associated with Epstein-Barr virus (EBV) infection. Presence of EBV IgA antibodies is rare among healthy individuals and is used as a marker of nasopharyngeal carcinoma in high-incidence populations. Reasons for EBV IgA seropositivity are unknown, but hig...
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ftnhri:oai:ir.nhri.org.tw:3990099045/2868 2023-07-02T03:32:25+02:00 Epstein-Barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland Friborg, J Jarrett, RF Liu, MY Falk, KI Koch, A Olsen, OR Duncan, P Wohlfarht, J Chen, JY Melbye, M National Institute of Cancer Research 2007-12 application/pdf 144650 bytes http://ir.nhri.org.tw/handle/3990099045/2868 http://ir.nhri.org.tw/bitstream/3990099045/2868/1/000250319100013.pdf en-US en_US eng WILEY Journal of Medical Virology. 2007 Dec;79(12):1877-1881. 0146-6615 10.1002/jmv.21014 http://ir.nhri.org.tw/handle/3990099045/2868 http://ir.nhri.org.tw/bitstream/3990099045/2868/1/000250319100013.pdf Virology Article 2007 ftnhri 2023-06-13T16:08:08Z Undifferentiated nasopharyngeal carcinoma is associated with Epstein-Barr virus (EBV) infection. Presence of EBV IgA antibodies is rare among healthy individuals and is used as a marker of nasopharyngeal carcinoma in high-incidence populations. Reasons for EBV IgA seropositivity are unknown, but high EBV IgA levels have been found among unaffected close family members and spouses to nasopharyngeal carcinoma patients in Chinese populations. In Greenland, a nasopharyngeal carcinoma-high-incidence area, we compared EBV serology and viral load in high-risk nasopharyngeal carcinoma family members (N=20) and controls without nasopharyngeal carcinoma-affected relatives (N = 90). There was no significant difference in EBV viral loads between relatives and controls, and EBV was detected in plasma in 5.0% of relatives and 11.4% of controls. There was no significant difference in EBV serology, but the seroprevalence of EBV viral capsid antigen (VCA) IgA was high in both relatives (25.0%) and controls (20.5%). Compared with anti-VCA IgA-negative, anti-VCA IgA-positive individuals had significantly higher EBV viral loads in peripheral blood mononuclear cells (PBMCs) (P<0.01). The very high prevalence of anti-VCA IgA indicates that this antibody is unsuitable for nasopharyngeal carcinoma screening among Inuits. Article in Journal/Newspaper Greenland inuits National Health Research Institutes (NHRI): Institutional Repository Greenland |
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Open Polar |
collection |
National Health Research Institutes (NHRI): Institutional Repository |
op_collection_id |
ftnhri |
language |
English |
topic |
Virology |
spellingShingle |
Virology Friborg, J Jarrett, RF Liu, MY Falk, KI Koch, A Olsen, OR Duncan, P Wohlfarht, J Chen, JY Melbye, M Epstein-Barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland |
topic_facet |
Virology |
description |
Undifferentiated nasopharyngeal carcinoma is associated with Epstein-Barr virus (EBV) infection. Presence of EBV IgA antibodies is rare among healthy individuals and is used as a marker of nasopharyngeal carcinoma in high-incidence populations. Reasons for EBV IgA seropositivity are unknown, but high EBV IgA levels have been found among unaffected close family members and spouses to nasopharyngeal carcinoma patients in Chinese populations. In Greenland, a nasopharyngeal carcinoma-high-incidence area, we compared EBV serology and viral load in high-risk nasopharyngeal carcinoma family members (N=20) and controls without nasopharyngeal carcinoma-affected relatives (N = 90). There was no significant difference in EBV viral loads between relatives and controls, and EBV was detected in plasma in 5.0% of relatives and 11.4% of controls. There was no significant difference in EBV serology, but the seroprevalence of EBV viral capsid antigen (VCA) IgA was high in both relatives (25.0%) and controls (20.5%). Compared with anti-VCA IgA-negative, anti-VCA IgA-positive individuals had significantly higher EBV viral loads in peripheral blood mononuclear cells (PBMCs) (P<0.01). The very high prevalence of anti-VCA IgA indicates that this antibody is unsuitable for nasopharyngeal carcinoma screening among Inuits. |
author2 |
National Institute of Cancer Research |
format |
Article in Journal/Newspaper |
author |
Friborg, J Jarrett, RF Liu, MY Falk, KI Koch, A Olsen, OR Duncan, P Wohlfarht, J Chen, JY Melbye, M |
author_facet |
Friborg, J Jarrett, RF Liu, MY Falk, KI Koch, A Olsen, OR Duncan, P Wohlfarht, J Chen, JY Melbye, M |
author_sort |
Friborg, J |
title |
Epstein-Barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland |
title_short |
Epstein-Barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland |
title_full |
Epstein-Barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland |
title_fullStr |
Epstein-Barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland |
title_full_unstemmed |
Epstein-Barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland |
title_sort |
epstein-barr virus immune response in high-risk nasopharyngeal carcinoma families in greenland |
publisher |
WILEY |
publishDate |
2007 |
url |
http://ir.nhri.org.tw/handle/3990099045/2868 http://ir.nhri.org.tw/bitstream/3990099045/2868/1/000250319100013.pdf |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuits |
genre_facet |
Greenland inuits |
op_relation |
Journal of Medical Virology. 2007 Dec;79(12):1877-1881. 0146-6615 10.1002/jmv.21014 http://ir.nhri.org.tw/handle/3990099045/2868 http://ir.nhri.org.tw/bitstream/3990099045/2868/1/000250319100013.pdf |
_version_ |
1770271994246332416 |