Pathogenic potential of an environmental Aspergillus fumigatus strain recovered from soil of Pygoscelis papua (Gentoo Penguins) colony in Antarctica
Aspergillus fumigatus is a common opportunistic pathogen in different animals, including birds such as penguins. For the first time, a fungal strain identified as A. fumigatus was isolated from soil in the nests of gentoo penguins, Pygoscelis papua, on Livingston Island, South Shetland Islands (mari...
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ftnerc:oai:nora.nerc.ac.uk:534510 2024-05-19T07:32:34+00:00 Pathogenic potential of an environmental Aspergillus fumigatus strain recovered from soil of Pygoscelis papua (Gentoo Penguins) colony in Antarctica Gonçalves, Vívian Nicolau Amorim, Soraya Sander da Costa, Marliete Carvalho de Assis Santos, Daniel Convey, Peter Rosa, Luiz Henrique 2024-04-23 http://nora.nerc.ac.uk/id/eprint/534510/ https://link.springer.com/article/10.1007/s42770-024-01326-w unknown Springer Gonçalves, Vívian Nicolau; Amorim, Soraya Sander; da Costa, Marliete Carvalho; de Assis Santos, Daniel; Convey, Peter orcid:0000-0001-8497-9903 Rosa, Luiz Henrique. 2024 Pathogenic potential of an environmental Aspergillus fumigatus strain recovered from soil of Pygoscelis papua (Gentoo Penguins) colony in Antarctica. Brazilian Journal of Microbiology. 8, pp. https://doi.org/10.1007/s42770-024-01326-w <https://doi.org/10.1007/s42770-024-01326-w> Publication - Article PeerReviewed 2024 ftnerc https://doi.org/10.1007/s42770-024-01326-w 2024-04-30T23:32:31Z Aspergillus fumigatus is a common opportunistic pathogen in different animals, including birds such as penguins. For the first time, a fungal strain identified as A. fumigatus was isolated from soil in the nests of gentoo penguins, Pygoscelis papua, on Livingston Island, South Shetland Islands (maritime Antarctica). This isolate (A. fumigatus UFMGCB 11829) displayed a series of potentially pathogenic characteristics in vitro. We evaluated its detailed molecular taxonomy and submitted the A. fumigatus UFMGCB 11829 Antarctic strain to in vivo pathogenic modelling. The isolate was confirmed to represent A. fumigatus morphological and phylogenetic analysis showed that it was closely related to A. fumigatus sequences reported from animals, immunosuppressed humans, storage grains, plants and soils. The strain displayed the best mycelial growth and conidia production at 37 ºC; however, it was also able to grow and produce conidia at 15º, demonstrating its capability to survive and colonize penguin nest at least in the summer season in maritime Antarctica. In pathogenicity tests, healthy mice did not showed symptoms of infection; however, 50% lethality was observed in immunosuppressed mice that were inoculated with 106 and 107 spores. Lethality increased to 100% when inoculated with 108 spores. Our data highlight the potential pathogenicity of opportunistic A. fumigatus that may be present in the Antarctic, and the risks of both their further transfer within Antarctica and outwards to other continents, risks which may be exacerbated due global climatic changes. Article in Journal/Newspaper Antarc* Antarctic Antarctica Livingston Island Pygoscelis papua South Shetland Islands Natural Environment Research Council: NERC Open Research Archive Brazilian Journal of Microbiology |
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Open Polar |
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Natural Environment Research Council: NERC Open Research Archive |
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description |
Aspergillus fumigatus is a common opportunistic pathogen in different animals, including birds such as penguins. For the first time, a fungal strain identified as A. fumigatus was isolated from soil in the nests of gentoo penguins, Pygoscelis papua, on Livingston Island, South Shetland Islands (maritime Antarctica). This isolate (A. fumigatus UFMGCB 11829) displayed a series of potentially pathogenic characteristics in vitro. We evaluated its detailed molecular taxonomy and submitted the A. fumigatus UFMGCB 11829 Antarctic strain to in vivo pathogenic modelling. The isolate was confirmed to represent A. fumigatus morphological and phylogenetic analysis showed that it was closely related to A. fumigatus sequences reported from animals, immunosuppressed humans, storage grains, plants and soils. The strain displayed the best mycelial growth and conidia production at 37 ºC; however, it was also able to grow and produce conidia at 15º, demonstrating its capability to survive and colonize penguin nest at least in the summer season in maritime Antarctica. In pathogenicity tests, healthy mice did not showed symptoms of infection; however, 50% lethality was observed in immunosuppressed mice that were inoculated with 106 and 107 spores. Lethality increased to 100% when inoculated with 108 spores. Our data highlight the potential pathogenicity of opportunistic A. fumigatus that may be present in the Antarctic, and the risks of both their further transfer within Antarctica and outwards to other continents, risks which may be exacerbated due global climatic changes. |
format |
Article in Journal/Newspaper |
author |
Gonçalves, Vívian Nicolau Amorim, Soraya Sander da Costa, Marliete Carvalho de Assis Santos, Daniel Convey, Peter Rosa, Luiz Henrique |
spellingShingle |
Gonçalves, Vívian Nicolau Amorim, Soraya Sander da Costa, Marliete Carvalho de Assis Santos, Daniel Convey, Peter Rosa, Luiz Henrique Pathogenic potential of an environmental Aspergillus fumigatus strain recovered from soil of Pygoscelis papua (Gentoo Penguins) colony in Antarctica |
author_facet |
Gonçalves, Vívian Nicolau Amorim, Soraya Sander da Costa, Marliete Carvalho de Assis Santos, Daniel Convey, Peter Rosa, Luiz Henrique |
author_sort |
Gonçalves, Vívian Nicolau |
title |
Pathogenic potential of an environmental Aspergillus fumigatus strain recovered from soil of Pygoscelis papua (Gentoo Penguins) colony in Antarctica |
title_short |
Pathogenic potential of an environmental Aspergillus fumigatus strain recovered from soil of Pygoscelis papua (Gentoo Penguins) colony in Antarctica |
title_full |
Pathogenic potential of an environmental Aspergillus fumigatus strain recovered from soil of Pygoscelis papua (Gentoo Penguins) colony in Antarctica |
title_fullStr |
Pathogenic potential of an environmental Aspergillus fumigatus strain recovered from soil of Pygoscelis papua (Gentoo Penguins) colony in Antarctica |
title_full_unstemmed |
Pathogenic potential of an environmental Aspergillus fumigatus strain recovered from soil of Pygoscelis papua (Gentoo Penguins) colony in Antarctica |
title_sort |
pathogenic potential of an environmental aspergillus fumigatus strain recovered from soil of pygoscelis papua (gentoo penguins) colony in antarctica |
publisher |
Springer |
publishDate |
2024 |
url |
http://nora.nerc.ac.uk/id/eprint/534510/ https://link.springer.com/article/10.1007/s42770-024-01326-w |
genre |
Antarc* Antarctic Antarctica Livingston Island Pygoscelis papua South Shetland Islands |
genre_facet |
Antarc* Antarctic Antarctica Livingston Island Pygoscelis papua South Shetland Islands |
op_relation |
Gonçalves, Vívian Nicolau; Amorim, Soraya Sander; da Costa, Marliete Carvalho; de Assis Santos, Daniel; Convey, Peter orcid:0000-0001-8497-9903 Rosa, Luiz Henrique. 2024 Pathogenic potential of an environmental Aspergillus fumigatus strain recovered from soil of Pygoscelis papua (Gentoo Penguins) colony in Antarctica. Brazilian Journal of Microbiology. 8, pp. https://doi.org/10.1007/s42770-024-01326-w <https://doi.org/10.1007/s42770-024-01326-w> |
op_doi |
https://doi.org/10.1007/s42770-024-01326-w |
container_title |
Brazilian Journal of Microbiology |
_version_ |
1799470669302333440 |