Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird
Over evolutionary time, pathogen challenge shapes the immune phenotype of the host to better respond to an incipient threat. The extent and direction of this selection pressure depends on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. H...
Published in: | Molecular Biology and Evolution |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Oxford University Press
2020
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Online Access: | http://nora.nerc.ac.uk/id/eprint/527074/ https://nora.nerc.ac.uk/id/eprint/527074/1/msaa040.pdf https://nora.nerc.ac.uk/id/eprint/527074/2/msaa040_supplementary_information.pdf https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msaa040/5756218 |
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ftnerc:oai:nora.nerc.ac.uk:527074 2023-05-15T16:19:37+02:00 Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird Levy, Hila Fiddaman, Steven R. Vianna, Juliana A. Noll, Daly Clucas, Gemma V. Sidhu, Jasmine K.H. Polito, Michael J. Bost, Charles A. Phillips, Richard Crofts, Sarah Miller, Gary D. Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés A. Trathan, Phil Rey, Andrea Raya Frantz, Laurent A.F. Hart, Tom Smith, Adrian L. 2020-06-01 text http://nora.nerc.ac.uk/id/eprint/527074/ https://nora.nerc.ac.uk/id/eprint/527074/1/msaa040.pdf https://nora.nerc.ac.uk/id/eprint/527074/2/msaa040_supplementary_information.pdf https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msaa040/5756218 en eng Oxford University Press https://nora.nerc.ac.uk/id/eprint/527074/1/msaa040.pdf https://nora.nerc.ac.uk/id/eprint/527074/2/msaa040_supplementary_information.pdf Levy, Hila; Fiddaman, Steven R.; Vianna, Juliana A.; Noll, Daly; Clucas, Gemma V.; Sidhu, Jasmine K.H.; Polito, Michael J.; Bost, Charles A.; Phillips, Richard; Crofts, Sarah; Miller, Gary D.; Pistorius, Pierre; Bonnadonna, Francesco; Le Bohec, Céline; Barbosa, Andrés A.; Trathan, Phil orcid:0000-0001-6673-9930 Rey, Andrea Raya; Frantz, Laurent A.F.; Hart, Tom; Smith, Adrian L. 2020 Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird. Molecular Biology and Evolution, 37 (6). 1708-1726. https://doi.org/10.1093/molbev/msaa040 <https://doi.org/10.1093/molbev/msaa040> cc_by_4 CC-BY Publication - Article PeerReviewed 2020 ftnerc https://doi.org/10.1093/molbev/msaa040 2023-02-04T19:50:20Z Over evolutionary time, pathogen challenge shapes the immune phenotype of the host to better respond to an incipient threat. The extent and direction of this selection pressure depends on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation because of its circumpolar distribution over a large latitudinal range, with little or no admixture between different clades. In this study, we examine the diversity in a key family of innate immune genes - the Toll-like receptors (TLRs) - across the range of the Gentoo. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7. We present evidence of positive selection in TLR4 and TLR5, which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected co-segregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo as a sentinel species in some of the world’s most rapidly changing environments. Article in Journal/Newspaper Gentoo penguin Pygoscelis papua Natural Environment Research Council: NERC Open Research Archive Molecular Biology and Evolution 37 6 1708 1726 |
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Open Polar |
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Natural Environment Research Council: NERC Open Research Archive |
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ftnerc |
language |
English |
description |
Over evolutionary time, pathogen challenge shapes the immune phenotype of the host to better respond to an incipient threat. The extent and direction of this selection pressure depends on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation because of its circumpolar distribution over a large latitudinal range, with little or no admixture between different clades. In this study, we examine the diversity in a key family of innate immune genes - the Toll-like receptors (TLRs) - across the range of the Gentoo. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7. We present evidence of positive selection in TLR4 and TLR5, which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected co-segregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo as a sentinel species in some of the world’s most rapidly changing environments. |
format |
Article in Journal/Newspaper |
author |
Levy, Hila Fiddaman, Steven R. Vianna, Juliana A. Noll, Daly Clucas, Gemma V. Sidhu, Jasmine K.H. Polito, Michael J. Bost, Charles A. Phillips, Richard Crofts, Sarah Miller, Gary D. Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés A. Trathan, Phil Rey, Andrea Raya Frantz, Laurent A.F. Hart, Tom Smith, Adrian L. |
spellingShingle |
Levy, Hila Fiddaman, Steven R. Vianna, Juliana A. Noll, Daly Clucas, Gemma V. Sidhu, Jasmine K.H. Polito, Michael J. Bost, Charles A. Phillips, Richard Crofts, Sarah Miller, Gary D. Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés A. Trathan, Phil Rey, Andrea Raya Frantz, Laurent A.F. Hart, Tom Smith, Adrian L. Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
author_facet |
Levy, Hila Fiddaman, Steven R. Vianna, Juliana A. Noll, Daly Clucas, Gemma V. Sidhu, Jasmine K.H. Polito, Michael J. Bost, Charles A. Phillips, Richard Crofts, Sarah Miller, Gary D. Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés A. Trathan, Phil Rey, Andrea Raya Frantz, Laurent A.F. Hart, Tom Smith, Adrian L. |
author_sort |
Levy, Hila |
title |
Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
title_short |
Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
title_full |
Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
title_fullStr |
Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
title_full_unstemmed |
Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
title_sort |
evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
publisher |
Oxford University Press |
publishDate |
2020 |
url |
http://nora.nerc.ac.uk/id/eprint/527074/ https://nora.nerc.ac.uk/id/eprint/527074/1/msaa040.pdf https://nora.nerc.ac.uk/id/eprint/527074/2/msaa040_supplementary_information.pdf https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msaa040/5756218 |
genre |
Gentoo penguin Pygoscelis papua |
genre_facet |
Gentoo penguin Pygoscelis papua |
op_relation |
https://nora.nerc.ac.uk/id/eprint/527074/1/msaa040.pdf https://nora.nerc.ac.uk/id/eprint/527074/2/msaa040_supplementary_information.pdf Levy, Hila; Fiddaman, Steven R.; Vianna, Juliana A.; Noll, Daly; Clucas, Gemma V.; Sidhu, Jasmine K.H.; Polito, Michael J.; Bost, Charles A.; Phillips, Richard; Crofts, Sarah; Miller, Gary D.; Pistorius, Pierre; Bonnadonna, Francesco; Le Bohec, Céline; Barbosa, Andrés A.; Trathan, Phil orcid:0000-0001-6673-9930 Rey, Andrea Raya; Frantz, Laurent A.F.; Hart, Tom; Smith, Adrian L. 2020 Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird. Molecular Biology and Evolution, 37 (6). 1708-1726. https://doi.org/10.1093/molbev/msaa040 <https://doi.org/10.1093/molbev/msaa040> |
op_rights |
cc_by_4 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/molbev/msaa040 |
container_title |
Molecular Biology and Evolution |
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37 |
container_issue |
6 |
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1708 |
op_container_end_page |
1726 |
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1766006027703025664 |