Age-related thermal response: the cellular resilience of juveniles
Understanding species’ responses to environmental challenges is key to predicting future biodiversity. However, there is currently little data on how developmental stages affect responses and also whether universal gene biomarkers to environmental stress can be identified both within and between spe...
Published in: | Cell Stress and Chaperones |
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ftnerc:oai:nora.nerc.ac.uk:510969 2023-05-15T13:49:32+02:00 Age-related thermal response: the cellular resilience of juveniles Clark, M.S. Thorne, M.A.S. Burns, G. Peck, L.S. 2016-01 text http://nora.nerc.ac.uk/id/eprint/510969/ https://nora.nerc.ac.uk/id/eprint/510969/1/Clark%20et%20al%20-%20Age%20related%20thermal%20response%20AAM.pdf http://link.springer.com/article/10.1007/s12192-015-0640-x en eng Springer https://nora.nerc.ac.uk/id/eprint/510969/1/Clark%20et%20al%20-%20Age%20related%20thermal%20response%20AAM.pdf Clark, M.S. orcid:0000-0002-3442-3824 Thorne, M.A.S. orcid:0000-0001-7759-612X Burns, G.; Peck, L.S. orcid:0000-0003-3479-6791 . 2016 Age-related thermal response: the cellular resilience of juveniles. Cell Stress and Chaperones, 21 (1). 75-85. https://doi.org/10.1007/s12192-015-0640-x <https://doi.org/10.1007/s12192-015-0640-x> Publication - Article PeerReviewed 2016 ftnerc https://doi.org/10.1007/s12192-015-0640-x 2023-02-04T19:41:42Z Understanding species’ responses to environmental challenges is key to predicting future biodiversity. However, there is currently little data on how developmental stages affect responses and also whether universal gene biomarkers to environmental stress can be identified both within and between species. Using the Antarctic clam, Laternula elliptica, as a model species, we examined both the tissue-specific and age-related (juvenile versus mature adult) gene expression response to acute non-lethal warming (12 h at 3 °C). In general, there was a relatively muted response to this sub-lethal thermal challenge when the expression profiles of treated animals, of either age, were compared with those of 0 °C controls, with none of the “classical” stress response genes up-regulated. The expression profiles were very variable between the tissues of all animals, irrespective of age with no single transcript emerging as a universal biomarker of thermal stress. However, when the expression profiles of treated animals of the different age groups were directly compared, a very different pattern emerged. The profiles of the younger animals showed significant up-regulation of chaperone and antioxidant transcripts when compared with those of the older animals. Thus, the younger animals showed evidence of a more robust cellular response to warming. These data substantiate previous physiological analyses showing a more resilient juvenile population. Article in Journal/Newspaper Antarc* Antarctic Natural Environment Research Council: NERC Open Research Archive Antarctic The Antarctic Cell Stress and Chaperones 21 1 75 85 |
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Natural Environment Research Council: NERC Open Research Archive |
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ftnerc |
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English |
description |
Understanding species’ responses to environmental challenges is key to predicting future biodiversity. However, there is currently little data on how developmental stages affect responses and also whether universal gene biomarkers to environmental stress can be identified both within and between species. Using the Antarctic clam, Laternula elliptica, as a model species, we examined both the tissue-specific and age-related (juvenile versus mature adult) gene expression response to acute non-lethal warming (12 h at 3 °C). In general, there was a relatively muted response to this sub-lethal thermal challenge when the expression profiles of treated animals, of either age, were compared with those of 0 °C controls, with none of the “classical” stress response genes up-regulated. The expression profiles were very variable between the tissues of all animals, irrespective of age with no single transcript emerging as a universal biomarker of thermal stress. However, when the expression profiles of treated animals of the different age groups were directly compared, a very different pattern emerged. The profiles of the younger animals showed significant up-regulation of chaperone and antioxidant transcripts when compared with those of the older animals. Thus, the younger animals showed evidence of a more robust cellular response to warming. These data substantiate previous physiological analyses showing a more resilient juvenile population. |
format |
Article in Journal/Newspaper |
author |
Clark, M.S. Thorne, M.A.S. Burns, G. Peck, L.S. |
spellingShingle |
Clark, M.S. Thorne, M.A.S. Burns, G. Peck, L.S. Age-related thermal response: the cellular resilience of juveniles |
author_facet |
Clark, M.S. Thorne, M.A.S. Burns, G. Peck, L.S. |
author_sort |
Clark, M.S. |
title |
Age-related thermal response: the cellular resilience of juveniles |
title_short |
Age-related thermal response: the cellular resilience of juveniles |
title_full |
Age-related thermal response: the cellular resilience of juveniles |
title_fullStr |
Age-related thermal response: the cellular resilience of juveniles |
title_full_unstemmed |
Age-related thermal response: the cellular resilience of juveniles |
title_sort |
age-related thermal response: the cellular resilience of juveniles |
publisher |
Springer |
publishDate |
2016 |
url |
http://nora.nerc.ac.uk/id/eprint/510969/ https://nora.nerc.ac.uk/id/eprint/510969/1/Clark%20et%20al%20-%20Age%20related%20thermal%20response%20AAM.pdf http://link.springer.com/article/10.1007/s12192-015-0640-x |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
https://nora.nerc.ac.uk/id/eprint/510969/1/Clark%20et%20al%20-%20Age%20related%20thermal%20response%20AAM.pdf Clark, M.S. orcid:0000-0002-3442-3824 Thorne, M.A.S. orcid:0000-0001-7759-612X Burns, G.; Peck, L.S. orcid:0000-0003-3479-6791 . 2016 Age-related thermal response: the cellular resilience of juveniles. Cell Stress and Chaperones, 21 (1). 75-85. https://doi.org/10.1007/s12192-015-0640-x <https://doi.org/10.1007/s12192-015-0640-x> |
op_doi |
https://doi.org/10.1007/s12192-015-0640-x |
container_title |
Cell Stress and Chaperones |
container_volume |
21 |
container_issue |
1 |
container_start_page |
75 |
op_container_end_page |
85 |
_version_ |
1766251495234207744 |