Estimation of Some Biomarkers of Liver Damage and Its Tissue in Male Albino Rats Treated with Isotretinoin AT Different Periods

• Main Authors: Abass, Z. M. (Zainab), Al-Harbi, H. J. (Hussein)
• Format: Article in Journal/Newspaper
• Language: Indonesian
• Published: ScienceScholar 2022
• Subjects: Isotretinoin; liver enzyme; Indonesia; 13-cis-retinoic acid; kallistainen; FABP1; Babylon; Rattus rattus
• Online Access: https://www.neliti.com/publications/576402/estimation-of-some-biomarkers-of-liver-damage-and-its-tissue-in-male-albino-rats

Isotretinoin, commonly known as 13-cis-retinoic acid, is a vitamin derivative used to treat severe acne and several types of skin, head, and neck cancer. According to certain research, isotretinoin causes apoptosis in a number of different types of bodily cells. In instances of clinically obvious acute liver injury with jaundice, isotretinoin has not been definitively linked. It is unknown how isotretinoin elevates serum aminotransferase levels, however, given that this effect seems to occur more frequently with a greater dose of medication, it may be a direct harmful impact. Methods: This study was conducted in the animal house in the College of Science / University of Babylon for the period from 22/11/2021 to 22/12/2021. The study included 40 white male albino rats (Rattus rattus) aged 2-3 months, weighing 100 to 150 g, and at a temperature of (25+3C) and 12 u (light-dark cycle) and then divided into eight groups, each group containing five rats. The animals were left before treatment for two weeks to acclimatize. After that, the rats were treated with Isotretinoin and they were given free water and a ration.