Cannabis use in pregnancy and maternal and infant outcomes: a Canadian cross-jurisdictional population-based cohort study.
BACKGROUND: With the recent legalization of cannabis in Canada, there is an urgent need to understand the effect of cannabis use in pregnancy. Our population-based study investigated the effects of prenatal cannabis use on maternal and newborn outcomes, and modification by infant sex. METHODS: The c...
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Public Library of Science
2022
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Online Access: | https://www.drugsandalcohol.ie/37904/ https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276824 https://doi.org/10.1371/journal.pone.0276824 |
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Open Polar |
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HRB National Drugs Library (Health Research Board) |
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unknown |
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Substance use behaviour Effects or consequences Cannabis / Marijuana Pregnancy Developmental disorder (reproductive effects) Pregnant woman Canada |
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Substance use behaviour Effects or consequences Cannabis / Marijuana Pregnancy Developmental disorder (reproductive effects) Pregnant woman Canada Luke, Sabrina Hobbs, Amy J Smith, Michaela Riddell, Catherine Murphy, Phil Agborsangaya, Calypse Cantin, Christina Fahey, John Der, Kenny Pederson, Ann Nelson, Chantal Cannabis use in pregnancy and maternal and infant outcomes: a Canadian cross-jurisdictional population-based cohort study. |
topic_facet |
Substance use behaviour Effects or consequences Cannabis / Marijuana Pregnancy Developmental disorder (reproductive effects) Pregnant woman Canada |
description |
BACKGROUND: With the recent legalization of cannabis in Canada, there is an urgent need to understand the effect of cannabis use in pregnancy. Our population-based study investigated the effects of prenatal cannabis use on maternal and newborn outcomes, and modification by infant sex. METHODS: The cohort included 1,280,447 singleton births from the British Columbia Perinatal Data Registry, the Better Outcomes Registry & Network Ontario, and the Perinatal Program Newfoundland Labrador from April 1st, 2012 to March 31st, 2019. Logistic regression determined the associations between prenatal cannabis use and low birth weight, small-for-gestational age, large-for-gestational age, spontaneous and medically indicated preterm birth, very preterm birth, stillbirth, major congenital anomalies, caesarean section, gestational diabetes and gestational hypertension. Models were adjusted for other substance use, socio-demographic and-economic characteristics, co-morbidities. Interaction terms were included to investigate modification by infant sex. RESULTS: The prevalence of cannabis use in our cohort was approximately 2%. Prenatal cannabis use is associated with increased risks of spontaneous and medically indicated preterm birth, very preterm birth, low birth weight, small-for-gestational age and large-for-gestational age, any major congenital anomaly, caesarean section, and gestational diabetes. No association was found for stillbirth or gestational hypertension. Only small-for-gestational age (p = 0.03) and spontaneous preterm birth (p = 0.04) showed evidence of modification by infant sex. CONCLUSIONS: Prenatal cannabis use increases the likelihood of preterm birth, low birth weight, small-for-gestational age and major congenital anomalies with prenatally exposed female infants showing evidence of increased susceptibility. Additional measures are needed to inform the public and providers of the inherent risks of cannabis exposure in pregnancy. |
format |
Article in Journal/Newspaper |
author |
Luke, Sabrina Hobbs, Amy J Smith, Michaela Riddell, Catherine Murphy, Phil Agborsangaya, Calypse Cantin, Christina Fahey, John Der, Kenny Pederson, Ann Nelson, Chantal |
author_facet |
Luke, Sabrina Hobbs, Amy J Smith, Michaela Riddell, Catherine Murphy, Phil Agborsangaya, Calypse Cantin, Christina Fahey, John Der, Kenny Pederson, Ann Nelson, Chantal |
author_sort |
Luke, Sabrina |
title |
Cannabis use in pregnancy and maternal and infant outcomes: a Canadian cross-jurisdictional population-based cohort study. |
title_short |
Cannabis use in pregnancy and maternal and infant outcomes: a Canadian cross-jurisdictional population-based cohort study. |
title_full |
Cannabis use in pregnancy and maternal and infant outcomes: a Canadian cross-jurisdictional population-based cohort study. |
title_fullStr |
Cannabis use in pregnancy and maternal and infant outcomes: a Canadian cross-jurisdictional population-based cohort study. |
title_full_unstemmed |
Cannabis use in pregnancy and maternal and infant outcomes: a Canadian cross-jurisdictional population-based cohort study. |
title_sort |
cannabis use in pregnancy and maternal and infant outcomes: a canadian cross-jurisdictional population-based cohort study. |
publisher |
Public Library of Science |
publishDate |
2022 |
url |
https://www.drugsandalcohol.ie/37904/ https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276824 https://doi.org/10.1371/journal.pone.0276824 |
long_lat |
ENVELOPE(-125.003,-125.003,54.000,54.000) |
geographic |
Newfoundland Canada British Columbia |
geographic_facet |
Newfoundland Canada British Columbia |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
Luke, Sabrina <https://www.drugsandalcohol.ie/view/people/Luke=3ASabrina=3A=3A.html> and Hobbs, Amy J <https://www.drugsandalcohol.ie/view/people/Hobbs=3AAmy_J=3A=3A.html> and Smith, Michaela <https://www.drugsandalcohol.ie/view/people/Smith=3AMichaela=3A=3A.html> and Riddell, Catherine <https://www.drugsandalcohol.ie/view/people/Riddell=3ACatherine=3A=3A.html> and Murphy, Phil <https://www.drugsandalcohol.ie/view/people/Murphy=3APhil=3A=3A.html> and Agborsangaya, Calypse <https://www.drugsandalcohol.ie/view/people/Agborsangaya=3ACalypse=3A=3A.html> and Cantin, Christina <https://www.drugsandalcohol.ie/view/people/Cantin=3AChristina=3A=3A.html> and Fahey, John <https://www.drugsandalcohol.ie/view/people/Fahey=3AJohn=3A=3A.html> and Der, Kenny <https://www.drugsandalcohol.ie/view/people/Der=3AKenny=3A=3A.html> and Pederson, Ann <https://www.drugsandalcohol.ie/view/people/Pederson=3AAnn=3A=3A.html> and Nelson, Chantal <https://www.drugsandalcohol.ie/view/people/Nelson=3AChantal=3A=3A.html> (2022) Cannabis use in pregnancy and maternal and infant outcomes: a Canadian cross-jurisdictional population-based cohort study. PLoS ONE, 17, (11), e0276824. doi:10.1371/journal.pone.0276824. |
op_doi |
https://doi.org/10.1371/journal.pone.0276824 |
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PLOS ONE |
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17 |
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11 |
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ftndcdu:oai:generic.eprints.org:37904 2023-07-30T04:05:03+02:00 Cannabis use in pregnancy and maternal and infant outcomes: a Canadian cross-jurisdictional population-based cohort study. Luke, Sabrina Hobbs, Amy J Smith, Michaela Riddell, Catherine Murphy, Phil Agborsangaya, Calypse Cantin, Christina Fahey, John Der, Kenny Pederson, Ann Nelson, Chantal 2022-11 https://www.drugsandalcohol.ie/37904/ https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276824 https://doi.org/10.1371/journal.pone.0276824 unknown Public Library of Science Luke, Sabrina <https://www.drugsandalcohol.ie/view/people/Luke=3ASabrina=3A=3A.html> and Hobbs, Amy J <https://www.drugsandalcohol.ie/view/people/Hobbs=3AAmy_J=3A=3A.html> and Smith, Michaela <https://www.drugsandalcohol.ie/view/people/Smith=3AMichaela=3A=3A.html> and Riddell, Catherine <https://www.drugsandalcohol.ie/view/people/Riddell=3ACatherine=3A=3A.html> and Murphy, Phil <https://www.drugsandalcohol.ie/view/people/Murphy=3APhil=3A=3A.html> and Agborsangaya, Calypse <https://www.drugsandalcohol.ie/view/people/Agborsangaya=3ACalypse=3A=3A.html> and Cantin, Christina <https://www.drugsandalcohol.ie/view/people/Cantin=3AChristina=3A=3A.html> and Fahey, John <https://www.drugsandalcohol.ie/view/people/Fahey=3AJohn=3A=3A.html> and Der, Kenny <https://www.drugsandalcohol.ie/view/people/Der=3AKenny=3A=3A.html> and Pederson, Ann <https://www.drugsandalcohol.ie/view/people/Pederson=3AAnn=3A=3A.html> and Nelson, Chantal <https://www.drugsandalcohol.ie/view/people/Nelson=3AChantal=3A=3A.html> (2022) Cannabis use in pregnancy and maternal and infant outcomes: a Canadian cross-jurisdictional population-based cohort study. PLoS ONE, 17, (11), e0276824. doi:10.1371/journal.pone.0276824. Substance use behaviour Effects or consequences Cannabis / Marijuana Pregnancy Developmental disorder (reproductive effects) Pregnant woman Canada Article PeerReviewed 2022 ftndcdu https://doi.org/10.1371/journal.pone.0276824 2023-07-10T21:29:55Z BACKGROUND: With the recent legalization of cannabis in Canada, there is an urgent need to understand the effect of cannabis use in pregnancy. Our population-based study investigated the effects of prenatal cannabis use on maternal and newborn outcomes, and modification by infant sex. METHODS: The cohort included 1,280,447 singleton births from the British Columbia Perinatal Data Registry, the Better Outcomes Registry & Network Ontario, and the Perinatal Program Newfoundland Labrador from April 1st, 2012 to March 31st, 2019. Logistic regression determined the associations between prenatal cannabis use and low birth weight, small-for-gestational age, large-for-gestational age, spontaneous and medically indicated preterm birth, very preterm birth, stillbirth, major congenital anomalies, caesarean section, gestational diabetes and gestational hypertension. Models were adjusted for other substance use, socio-demographic and-economic characteristics, co-morbidities. Interaction terms were included to investigate modification by infant sex. RESULTS: The prevalence of cannabis use in our cohort was approximately 2%. Prenatal cannabis use is associated with increased risks of spontaneous and medically indicated preterm birth, very preterm birth, low birth weight, small-for-gestational age and large-for-gestational age, any major congenital anomaly, caesarean section, and gestational diabetes. No association was found for stillbirth or gestational hypertension. Only small-for-gestational age (p = 0.03) and spontaneous preterm birth (p = 0.04) showed evidence of modification by infant sex. CONCLUSIONS: Prenatal cannabis use increases the likelihood of preterm birth, low birth weight, small-for-gestational age and major congenital anomalies with prenatally exposed female infants showing evidence of increased susceptibility. Additional measures are needed to inform the public and providers of the inherent risks of cannabis exposure in pregnancy. Article in Journal/Newspaper Newfoundland HRB National Drugs Library (Health Research Board) Newfoundland Canada British Columbia ENVELOPE(-125.003,-125.003,54.000,54.000) PLOS ONE 17 11 e0276824 |