Aquatic ecotoxicological models and their applicability in Arctic regions
Abstract Dose-response modeling is one of the most important steps of ecological risk assessment. It requires concentration-effects relationships for the species under consideration. There are very limited studies and experimental data available for the Arctic aquatic species. Lack of toxicity data...
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ftnazarbayevuniv:oai:testnur.nu.edu.kz:123456789/3000 2023-05-15T14:35:30+02:00 Aquatic ecotoxicological models and their applicability in Arctic regions Faisal, Fahd Fahd, Faisal Khan, Faisal Veitch, Brian Yang, Ming 2017-07-15 http://nur.nu.edu.kz/handle/123456789/3000 https://doi.org/10.1016/j.marpolbul.2017.03.072 https://www.sciencedirect.com/science/article/pii/S0025326X17302928 en eng Marine Pollution Bulletin Marine Pollution Bulletin © 2017 Elsevier Ltd. All rights reserved. Arctic aquatic organisms Metabolomics Ecotoxicogenomics Toxicokinetics Toxicodynamic models Ecological risk assessment Article 2017 ftnazarbayevuniv https://doi.org/10.1016/j.marpolbul.2017.03.072 2019-04-02T14:35:57Z Abstract Dose-response modeling is one of the most important steps of ecological risk assessment. It requires concentration-effects relationships for the species under consideration. There are very limited studies and experimental data available for the Arctic aquatic species. Lack of toxicity data hinders obtaining dose-response relationships for lethal (LC50 values), sub-lethal and carcinogenic effects. Gaps in toxicity data could be filled using a variety of in-silico ecotoxicological methods. This paper reviews the suitability of such methods for the Arctic scenario. Mechanistic approaches like toxicokinetic and toxicodynamic analysis are found to be better suited for interspecies extrapolation than statistical methods, such as Quantitative Structure-Activity Relationships/Quantitative Structure Activity-Activity Relationship, ICE, and other empirical models, such as Haber's law and Ostwald's equation. A novel approach is proposed where the effects of the toxicant exposure are quantified based on the probability of cellular damage and metabolites interactions. This approach recommends modeling cellular damage using a toxicodynamic model and physiology or metabolites interactions using a toxicokinetic model. Together, these models provide more reliable estimates of toxicity in the Arctic aquatic species, which will assist in conducting ecological risk assessment of Arctic environment. Article in Journal/Newspaper Arctic Nazarbayev University Repository Arctic Marine Pollution Bulletin 120 1-2 428 437 |
institution |
Open Polar |
collection |
Nazarbayev University Repository |
op_collection_id |
ftnazarbayevuniv |
language |
English |
topic |
Arctic aquatic organisms Metabolomics Ecotoxicogenomics Toxicokinetics Toxicodynamic models Ecological risk assessment |
spellingShingle |
Arctic aquatic organisms Metabolomics Ecotoxicogenomics Toxicokinetics Toxicodynamic models Ecological risk assessment Faisal, Fahd Fahd, Faisal Khan, Faisal Veitch, Brian Yang, Ming Aquatic ecotoxicological models and their applicability in Arctic regions |
topic_facet |
Arctic aquatic organisms Metabolomics Ecotoxicogenomics Toxicokinetics Toxicodynamic models Ecological risk assessment |
description |
Abstract Dose-response modeling is one of the most important steps of ecological risk assessment. It requires concentration-effects relationships for the species under consideration. There are very limited studies and experimental data available for the Arctic aquatic species. Lack of toxicity data hinders obtaining dose-response relationships for lethal (LC50 values), sub-lethal and carcinogenic effects. Gaps in toxicity data could be filled using a variety of in-silico ecotoxicological methods. This paper reviews the suitability of such methods for the Arctic scenario. Mechanistic approaches like toxicokinetic and toxicodynamic analysis are found to be better suited for interspecies extrapolation than statistical methods, such as Quantitative Structure-Activity Relationships/Quantitative Structure Activity-Activity Relationship, ICE, and other empirical models, such as Haber's law and Ostwald's equation. A novel approach is proposed where the effects of the toxicant exposure are quantified based on the probability of cellular damage and metabolites interactions. This approach recommends modeling cellular damage using a toxicodynamic model and physiology or metabolites interactions using a toxicokinetic model. Together, these models provide more reliable estimates of toxicity in the Arctic aquatic species, which will assist in conducting ecological risk assessment of Arctic environment. |
format |
Article in Journal/Newspaper |
author |
Faisal, Fahd Fahd, Faisal Khan, Faisal Veitch, Brian Yang, Ming |
author_facet |
Faisal, Fahd Fahd, Faisal Khan, Faisal Veitch, Brian Yang, Ming |
author_sort |
Faisal, Fahd |
title |
Aquatic ecotoxicological models and their applicability in Arctic regions |
title_short |
Aquatic ecotoxicological models and their applicability in Arctic regions |
title_full |
Aquatic ecotoxicological models and their applicability in Arctic regions |
title_fullStr |
Aquatic ecotoxicological models and their applicability in Arctic regions |
title_full_unstemmed |
Aquatic ecotoxicological models and their applicability in Arctic regions |
title_sort |
aquatic ecotoxicological models and their applicability in arctic regions |
publisher |
Marine Pollution Bulletin |
publishDate |
2017 |
url |
http://nur.nu.edu.kz/handle/123456789/3000 https://doi.org/10.1016/j.marpolbul.2017.03.072 https://www.sciencedirect.com/science/article/pii/S0025326X17302928 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
Marine Pollution Bulletin |
op_rights |
© 2017 Elsevier Ltd. All rights reserved. |
op_doi |
https://doi.org/10.1016/j.marpolbul.2017.03.072 |
container_title |
Marine Pollution Bulletin |
container_volume |
120 |
container_issue |
1-2 |
container_start_page |
428 |
op_container_end_page |
437 |
_version_ |
1766308311305551872 |