Terrestrial Spaceflight Analogs: Antarctica
Alterations in immune cell distribution and function, circadian misalignment, stress and latent viral reactivation appear to persist during Antarctic winterover at Concordia Station. Some of these changes are similar to those observed in Astronauts, either during or immediately following spaceflight...
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ftnasantrs:oai:casi.ntrs.nasa.gov:20140002723 2023-05-15T14:05:05+02:00 Terrestrial Spaceflight Analogs: Antarctica Crucian, Brian Unclassified, Unlimited, Publicly available September 17, 2013 application/pdf http://hdl.handle.net/2060/20140002723 unknown Document ID: 20140002723 http://hdl.handle.net/2060/20140002723 No Copyright CASI Life Sciences (General) Aerospace Medicine JSC-CN-29501 HRP Space Analogs Class; 17 Sept. 2013; Houston, TX; United States 2013 ftnasantrs 2019-07-21T06:15:37Z Alterations in immune cell distribution and function, circadian misalignment, stress and latent viral reactivation appear to persist during Antarctic winterover at Concordia Station. Some of these changes are similar to those observed in Astronauts, either during or immediately following spaceflight. Others are unique to the Concordia analog. Based on some initial immune data and environmental conditions, Concordia winterover may be an appropriate analog for some flight-associated immune system changes and mission stress effects. An ongoing smaller control study at Neumayer III will address the influence of the hypoxic variable. Changes were observed in the peripheral blood leukocyte distribution consistent with immune mobilization, and similar to those observed during spaceflight. Alterations in cytokine production profiles were observed during winterover that are distinct from those observed during spaceflight, but potentially consistent with those observed during persistent hypobaric hypoxia. The reactivation of latent herpesviruses was observed during overwinter/isolation, that is consistently associated with dysregulation in immune function. Other/Unknown Material Antarc* Antarctic Antarctica NASA Technical Reports Server (NTRS) Antarctic Neumayer Concordia Station ENVELOPE(123.333,123.333,-75.100,-75.100) |
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Open Polar |
collection |
NASA Technical Reports Server (NTRS) |
op_collection_id |
ftnasantrs |
language |
unknown |
topic |
Life Sciences (General) Aerospace Medicine |
spellingShingle |
Life Sciences (General) Aerospace Medicine Crucian, Brian Terrestrial Spaceflight Analogs: Antarctica |
topic_facet |
Life Sciences (General) Aerospace Medicine |
description |
Alterations in immune cell distribution and function, circadian misalignment, stress and latent viral reactivation appear to persist during Antarctic winterover at Concordia Station. Some of these changes are similar to those observed in Astronauts, either during or immediately following spaceflight. Others are unique to the Concordia analog. Based on some initial immune data and environmental conditions, Concordia winterover may be an appropriate analog for some flight-associated immune system changes and mission stress effects. An ongoing smaller control study at Neumayer III will address the influence of the hypoxic variable. Changes were observed in the peripheral blood leukocyte distribution consistent with immune mobilization, and similar to those observed during spaceflight. Alterations in cytokine production profiles were observed during winterover that are distinct from those observed during spaceflight, but potentially consistent with those observed during persistent hypobaric hypoxia. The reactivation of latent herpesviruses was observed during overwinter/isolation, that is consistently associated with dysregulation in immune function. |
format |
Other/Unknown Material |
author |
Crucian, Brian |
author_facet |
Crucian, Brian |
author_sort |
Crucian, Brian |
title |
Terrestrial Spaceflight Analogs: Antarctica |
title_short |
Terrestrial Spaceflight Analogs: Antarctica |
title_full |
Terrestrial Spaceflight Analogs: Antarctica |
title_fullStr |
Terrestrial Spaceflight Analogs: Antarctica |
title_full_unstemmed |
Terrestrial Spaceflight Analogs: Antarctica |
title_sort |
terrestrial spaceflight analogs: antarctica |
publishDate |
2013 |
url |
http://hdl.handle.net/2060/20140002723 |
op_coverage |
Unclassified, Unlimited, Publicly available |
long_lat |
ENVELOPE(123.333,123.333,-75.100,-75.100) |
geographic |
Antarctic Neumayer Concordia Station |
geographic_facet |
Antarctic Neumayer Concordia Station |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_source |
CASI |
op_relation |
Document ID: 20140002723 http://hdl.handle.net/2060/20140002723 |
op_rights |
No Copyright |
_version_ |
1766276720740007936 |