Vitamin D Supplementation and Immune Response to Antarctic Winter
Maintaining vitamin D status without sunlight exposure is difficult without supplementation. This study was designed to better understand interrelationships between periodic cholecalciferol(vitamin D3) supplementation and immune function in Antarctic workers. The effect of 2 oral dosing regimens of...
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ftnasantrs:oai:casi.ntrs.nasa.gov:20110008643 2023-05-15T13:43:16+02:00 Vitamin D Supplementation and Immune Response to Antarctic Winter Mehta, S. K. Ploutz-Snyder, R. Pierson, D. L. Smith, Scott M. Locke, J. P. Bourbeau, Y. Zwart, S. R. Unclassified, Unlimited, Publicly available April 11, 2011 application/pdf http://hdl.handle.net/2060/20110008643 unknown Document ID: 20110008643 http://hdl.handle.net/2060/20110008643 Copyright, Distribution as joint owner in the copyright CASI Life Sciences (General) JSC-CN-23314 18th IAA Humans in Space Symposium; 11-15 Apr. 2011; Houston, TX; United States 2011 ftnasantrs 2019-07-21T01:05:12Z Maintaining vitamin D status without sunlight exposure is difficult without supplementation. This study was designed to better understand interrelationships between periodic cholecalciferol(vitamin D3) supplementation and immune function in Antarctic workers. The effect of 2 oral dosing regimens of vitamin D3 supplementation on vitamin D status and markers of immune function were evaluated in people in Antarctica with no ultraviolet light exposure for 6 mo. Participants were given a 2,000-IU (50 g) daily (n=15) or 10,000-IU (250 g) weekly (n=14) vitamin D3 supplement for 6 mo during a winter in Antarctica. Biological samples were collected at baseline and at 3 and 6 mo. Vitamin D intake, markers of vitamin D and bone metabolism, and latent virus reactivation were determined. After 6 mo the mean (SD) serum 25-hydroxyvitamin D3 concentration increased from 56 plus or minus 17 to 79 plus or minus 16 nmol/L and 52 plus or minus 10 to 69 plus or minus 9 nmol/L in the 2,000-IU/d and 10,000-IU/wk groups (main effect over time P less than 0.001). Participants with a greater BMI (participant BMI range = 19-43 grams per square meter) had a smaller increase in 25-hydroxyvitamin D3 after 6 mo supplementation (P less than 0.05). Participants with high serum cortisoland higher serum 25-hydroxyvitamin D3 were less likely to shed Epstein-Barr virus in saliva (P less than 0.05). The doses given raised vitamin D status in participants not exposed to sunlight for 6 mo, and the efficacy was influenced by baseline vitamin D status and BMI. The data also provide evidence that vitamin D, interacting with stress, can reduce risk of latent virus reactivation during the winter in Antarctica. Other/Unknown Material Antarc* Antarctic Antarctica NASA Technical Reports Server (NTRS) Antarctic |
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NASA Technical Reports Server (NTRS) |
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ftnasantrs |
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Life Sciences (General) |
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Life Sciences (General) Mehta, S. K. Ploutz-Snyder, R. Pierson, D. L. Smith, Scott M. Locke, J. P. Bourbeau, Y. Zwart, S. R. Vitamin D Supplementation and Immune Response to Antarctic Winter |
topic_facet |
Life Sciences (General) |
description |
Maintaining vitamin D status without sunlight exposure is difficult without supplementation. This study was designed to better understand interrelationships between periodic cholecalciferol(vitamin D3) supplementation and immune function in Antarctic workers. The effect of 2 oral dosing regimens of vitamin D3 supplementation on vitamin D status and markers of immune function were evaluated in people in Antarctica with no ultraviolet light exposure for 6 mo. Participants were given a 2,000-IU (50 g) daily (n=15) or 10,000-IU (250 g) weekly (n=14) vitamin D3 supplement for 6 mo during a winter in Antarctica. Biological samples were collected at baseline and at 3 and 6 mo. Vitamin D intake, markers of vitamin D and bone metabolism, and latent virus reactivation were determined. After 6 mo the mean (SD) serum 25-hydroxyvitamin D3 concentration increased from 56 plus or minus 17 to 79 plus or minus 16 nmol/L and 52 plus or minus 10 to 69 plus or minus 9 nmol/L in the 2,000-IU/d and 10,000-IU/wk groups (main effect over time P less than 0.001). Participants with a greater BMI (participant BMI range = 19-43 grams per square meter) had a smaller increase in 25-hydroxyvitamin D3 after 6 mo supplementation (P less than 0.05). Participants with high serum cortisoland higher serum 25-hydroxyvitamin D3 were less likely to shed Epstein-Barr virus in saliva (P less than 0.05). The doses given raised vitamin D status in participants not exposed to sunlight for 6 mo, and the efficacy was influenced by baseline vitamin D status and BMI. The data also provide evidence that vitamin D, interacting with stress, can reduce risk of latent virus reactivation during the winter in Antarctica. |
format |
Other/Unknown Material |
author |
Mehta, S. K. Ploutz-Snyder, R. Pierson, D. L. Smith, Scott M. Locke, J. P. Bourbeau, Y. Zwart, S. R. |
author_facet |
Mehta, S. K. Ploutz-Snyder, R. Pierson, D. L. Smith, Scott M. Locke, J. P. Bourbeau, Y. Zwart, S. R. |
author_sort |
Mehta, S. K. |
title |
Vitamin D Supplementation and Immune Response to Antarctic Winter |
title_short |
Vitamin D Supplementation and Immune Response to Antarctic Winter |
title_full |
Vitamin D Supplementation and Immune Response to Antarctic Winter |
title_fullStr |
Vitamin D Supplementation and Immune Response to Antarctic Winter |
title_full_unstemmed |
Vitamin D Supplementation and Immune Response to Antarctic Winter |
title_sort |
vitamin d supplementation and immune response to antarctic winter |
publishDate |
2011 |
url |
http://hdl.handle.net/2060/20110008643 |
op_coverage |
Unclassified, Unlimited, Publicly available |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_source |
CASI |
op_relation |
Document ID: 20110008643 http://hdl.handle.net/2060/20110008643 |
op_rights |
Copyright, Distribution as joint owner in the copyright |
_version_ |
1766186508470976512 |