Lab-on-a-Chip: From Astrobiology to the International Space Station
The continual and long-term habitation of enclosed environments, such as Antarctic stations, nuclear submarines and space stations, raises unique engineering, medical and operational challenges. There is no easy way out and no easy way to get supplies in. This situation elevates the importance of mo...
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ftnasantrs:oai:casi.ntrs.nasa.gov:20080023405 2023-05-15T13:43:16+02:00 Lab-on-a-Chip: From Astrobiology to the International Space Station Monaco, Lisa A. Morris, Heather C. Wells, Mark E. Gunter, Dan Maule, Jake Steele, Andrew Boudreaux, Mark E. Wainwright, Nor Unclassified, Unlimited, Publicly available April 16, 2008 application/pdf http://hdl.handle.net/2060/20080023405 unknown Document ID: 20080023405 http://hdl.handle.net/2060/20080023405 Copyright, Distribution as joint owner in the copyright CASI Exobiology Astrobiology Science Conference 2008 -- SETI Institute; 14-17 Apr. 2008; Santa Clara, CA; United States 2008 ftnasantrs 2019-07-21T01:30:47Z The continual and long-term habitation of enclosed environments, such as Antarctic stations, nuclear submarines and space stations, raises unique engineering, medical and operational challenges. There is no easy way out and no easy way to get supplies in. This situation elevates the importance of monitoring technology that can rapidly detect events within the habitat that affect crew safety such as fire, release of toxic chemicals and hazardous microorganisms. Traditional methods to monitor microorganisms on the International Space Station (ISS) have consisted of culturing samples for 3-5 days and eventual sample return to Earth. To augment these culture methods with new, rapid molecular techniques, we developed the Lab-on-a-Chip Application Development - Portable Test System (LOCAD-PTS). The system consists of a hand-held spectrophotometer, a series of interchangeable cartridges and a surface sampling/dilution kit that enables crew to collect samples and detect a range of biological molecules, all within 15 minutes. LOCAD-PTS was launched to the ISS aboard Space Shuttle Discovery in December 2006, where it was operated for the first time during March-May 2007. The surfaces of five separate sites in the US Lab and Node 1 of ISS were analyzed for endotoxin, using cartridges that employ the Limulus Amebocyte Lysate (LAL) assay; results of these tests will be presented. LOCAD-PTS will remain permanently onboard ISS with new cartridges scheduled for launch in February and October of 2008 for the detection of fungi (Beta-glucan) and Gram-positive bacteria (lipoteichoic acid), respectively. Other/Unknown Material Antarc* Antarctic NASA Technical Reports Server (NTRS) Antarctic |
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NASA Technical Reports Server (NTRS) |
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topic |
Exobiology |
spellingShingle |
Exobiology Monaco, Lisa A. Morris, Heather C. Wells, Mark E. Gunter, Dan Maule, Jake Steele, Andrew Boudreaux, Mark E. Wainwright, Nor Lab-on-a-Chip: From Astrobiology to the International Space Station |
topic_facet |
Exobiology |
description |
The continual and long-term habitation of enclosed environments, such as Antarctic stations, nuclear submarines and space stations, raises unique engineering, medical and operational challenges. There is no easy way out and no easy way to get supplies in. This situation elevates the importance of monitoring technology that can rapidly detect events within the habitat that affect crew safety such as fire, release of toxic chemicals and hazardous microorganisms. Traditional methods to monitor microorganisms on the International Space Station (ISS) have consisted of culturing samples for 3-5 days and eventual sample return to Earth. To augment these culture methods with new, rapid molecular techniques, we developed the Lab-on-a-Chip Application Development - Portable Test System (LOCAD-PTS). The system consists of a hand-held spectrophotometer, a series of interchangeable cartridges and a surface sampling/dilution kit that enables crew to collect samples and detect a range of biological molecules, all within 15 minutes. LOCAD-PTS was launched to the ISS aboard Space Shuttle Discovery in December 2006, where it was operated for the first time during March-May 2007. The surfaces of five separate sites in the US Lab and Node 1 of ISS were analyzed for endotoxin, using cartridges that employ the Limulus Amebocyte Lysate (LAL) assay; results of these tests will be presented. LOCAD-PTS will remain permanently onboard ISS with new cartridges scheduled for launch in February and October of 2008 for the detection of fungi (Beta-glucan) and Gram-positive bacteria (lipoteichoic acid), respectively. |
format |
Other/Unknown Material |
author |
Monaco, Lisa A. Morris, Heather C. Wells, Mark E. Gunter, Dan Maule, Jake Steele, Andrew Boudreaux, Mark E. Wainwright, Nor |
author_facet |
Monaco, Lisa A. Morris, Heather C. Wells, Mark E. Gunter, Dan Maule, Jake Steele, Andrew Boudreaux, Mark E. Wainwright, Nor |
author_sort |
Monaco, Lisa A. |
title |
Lab-on-a-Chip: From Astrobiology to the International Space Station |
title_short |
Lab-on-a-Chip: From Astrobiology to the International Space Station |
title_full |
Lab-on-a-Chip: From Astrobiology to the International Space Station |
title_fullStr |
Lab-on-a-Chip: From Astrobiology to the International Space Station |
title_full_unstemmed |
Lab-on-a-Chip: From Astrobiology to the International Space Station |
title_sort |
lab-on-a-chip: from astrobiology to the international space station |
publishDate |
2008 |
url |
http://hdl.handle.net/2060/20080023405 |
op_coverage |
Unclassified, Unlimited, Publicly available |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
CASI |
op_relation |
Document ID: 20080023405 http://hdl.handle.net/2060/20080023405 |
op_rights |
Copyright, Distribution as joint owner in the copyright |
_version_ |
1766186603446796288 |