Immune Function Changes during a Spaceflight-Analog Undersea Mission
There is ample evidence to suggest that space flight leads to immune system dysregulation. This may be a result of microgravity, confinement, physiological stress, radiation, environment or other mission-associated factors. It is attractive to utilize ground-based spaceflight analogs as appropriate...
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ftnasantrs:oai:casi.ntrs.nasa.gov:20080010619 2023-05-15T13:34:40+02:00 Immune Function Changes during a Spaceflight-Analog Undersea Mission Mehta, Satish Quiniarte, Heather Sams, Clarence Pierson, Duane Yetman, Deborah Crucian, Brian Stowe, Raymond Unclassified, Unlimited, Publicly available February 04, 2008 application/pdf http://hdl.handle.net/2060/20080010619 unknown Document ID: 20080010619 http://hdl.handle.net/2060/20080010619 Copyright, Distribution as joint owner in the copyright CASI Aerospace Medicine 2008 ftnasantrs 2018-06-23T23:14:16Z There is ample evidence to suggest that space flight leads to immune system dysregulation. This may be a result of microgravity, confinement, physiological stress, radiation, environment or other mission-associated factors. It is attractive to utilize ground-based spaceflight analogs as appropriate to investigate this phenomenon. For spaceflight-associated immune dysregulation (SAID), the authors believe the most appropriate analogs might be NEEMO (short duration, Shuttle analog), Antarctic winter-over (long-duration, ISS analog) and the Haughton Mars Project in the Canadian Arctic (intermediate-duration). Each of these analogs replicate isolation, mission-associated stress, disrupted circadian rhythms, and other aspects of flight thought to contribute to SAID. To validate NEEMO as a flight analog with respect to SAID, a pilot study was conducted during the NEEMO-12 and 13 missions during 2007. Assays were performed that assessed immune status, physiological stress and latent viral reactivation. Blood and saliva samples were collected at pre-, mid-, and post-mission timepoints. Other/Unknown Material Antarc* Antarctic Arctic NASA Technical Reports Server (NTRS) Antarctic Arctic |
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Open Polar |
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NASA Technical Reports Server (NTRS) |
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ftnasantrs |
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unknown |
topic |
Aerospace Medicine |
spellingShingle |
Aerospace Medicine Mehta, Satish Quiniarte, Heather Sams, Clarence Pierson, Duane Yetman, Deborah Crucian, Brian Stowe, Raymond Immune Function Changes during a Spaceflight-Analog Undersea Mission |
topic_facet |
Aerospace Medicine |
description |
There is ample evidence to suggest that space flight leads to immune system dysregulation. This may be a result of microgravity, confinement, physiological stress, radiation, environment or other mission-associated factors. It is attractive to utilize ground-based spaceflight analogs as appropriate to investigate this phenomenon. For spaceflight-associated immune dysregulation (SAID), the authors believe the most appropriate analogs might be NEEMO (short duration, Shuttle analog), Antarctic winter-over (long-duration, ISS analog) and the Haughton Mars Project in the Canadian Arctic (intermediate-duration). Each of these analogs replicate isolation, mission-associated stress, disrupted circadian rhythms, and other aspects of flight thought to contribute to SAID. To validate NEEMO as a flight analog with respect to SAID, a pilot study was conducted during the NEEMO-12 and 13 missions during 2007. Assays were performed that assessed immune status, physiological stress and latent viral reactivation. Blood and saliva samples were collected at pre-, mid-, and post-mission timepoints. |
author |
Mehta, Satish Quiniarte, Heather Sams, Clarence Pierson, Duane Yetman, Deborah Crucian, Brian Stowe, Raymond |
author_facet |
Mehta, Satish Quiniarte, Heather Sams, Clarence Pierson, Duane Yetman, Deborah Crucian, Brian Stowe, Raymond |
author_sort |
Mehta, Satish |
title |
Immune Function Changes during a Spaceflight-Analog Undersea Mission |
title_short |
Immune Function Changes during a Spaceflight-Analog Undersea Mission |
title_full |
Immune Function Changes during a Spaceflight-Analog Undersea Mission |
title_fullStr |
Immune Function Changes during a Spaceflight-Analog Undersea Mission |
title_full_unstemmed |
Immune Function Changes during a Spaceflight-Analog Undersea Mission |
title_sort |
immune function changes during a spaceflight-analog undersea mission |
publishDate |
2008 |
url |
http://hdl.handle.net/2060/20080010619 |
op_coverage |
Unclassified, Unlimited, Publicly available |
geographic |
Antarctic Arctic |
geographic_facet |
Antarctic Arctic |
genre |
Antarc* Antarctic Arctic |
genre_facet |
Antarc* Antarctic Arctic |
op_source |
CASI |
op_relation |
Document ID: 20080010619 http://hdl.handle.net/2060/20080010619 |
op_rights |
Copyright, Distribution as joint owner in the copyright |
_version_ |
1766055693919453184 |