Field Immune Assessment during Simulated Planetary Exploration in the Canadian Arctic
Dysregulation of the immune system has been shown to occur during space flight, although the detailed nature of the phenomenon and the clinical risks for exploration class missions has yet to be established. In addition, the growing clinical significance of immune system evaluation combined with epi...
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ftnasantrs:oai:casi.ntrs.nasa.gov:20060052407 2023-05-15T15:01:49+02:00 Field Immune Assessment during Simulated Planetary Exploration in the Canadian Arctic Crucian, Brian Lee, Pascal Widen, Raymond Jones, Jeff Stowe, Raymond Sams, Clarence Effenhauser, Rainer Unclassified, Unlimited, Publicly available [2006] application/pdf http://hdl.handle.net/2060/20060052407 unknown Document ID: 20060052407 http://hdl.handle.net/2060/20060052407 Copyright, Distribution as joint owner in the copyright CASI Aerospace Medicine 2006 ftnasantrs 2018-06-23T23:15:45Z Dysregulation of the immune system has been shown to occur during space flight, although the detailed nature of the phenomenon and the clinical risks for exploration class missions has yet to be established. In addition, the growing clinical significance of immune system evaluation combined with epidemic infectious disease rates in third world countries provides a strong rationale for the development of field-compatible clinical immunology techniques and equipment. In July 2002 NASA performed a comprehensive field immunology assessment on crewmembers participating in the Haughton-Mars Project (HMP) on Devon Island in the high Canadian Arctic. The purpose of the study was to evaluate mission-associated effects on the human immune system, as well as to evaluate techniques developed for processing immune samples in remote field locations. Ten HMP-2002 participants volunteered for the study. A field protocol was developed at NASA-JSC for performing sample collection, blood staining/processing for immunophenotype analysis, wholeblood mitogenic culture for functional assessments and cell-sample preservation on-location at Devon Island. Specific assays included peripheral leukocyte distribution; constitutively activated T cells, intracellular cytokine profiles and plasma EBV viral antibody levels. Study timepoints were L-30, midmission and R+60. The protocol developed for immune sample processing in remote field locations functioned properly. Samples were processed in the field location, and stabilized for subsequent analysis at the Johnson Space Center in Houston. The data indicated that some phenotype, immune function and stress hormone changes occurred in the HMP field participants that were largely distinct from pre-mission baseline and post-mission recovery data. These immune changes appear similar to those observed in Astronauts following spaceflight. The sample processing protocol developed for this study may have applications for immune assessment during exploration-class space missions or in remote terrestrial field locations. The data validate the use of the HMP as a ground-based spaceflight/planetary exploration analog for some aspects of human physiology. Other/Unknown Material Arctic Devon Island NASA Technical Reports Server (NTRS) Arctic Devon Island ENVELOPE(-88.000,-88.000,75.252,75.252) |
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Open Polar |
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NASA Technical Reports Server (NTRS) |
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topic |
Aerospace Medicine |
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Aerospace Medicine Crucian, Brian Lee, Pascal Widen, Raymond Jones, Jeff Stowe, Raymond Sams, Clarence Effenhauser, Rainer Field Immune Assessment during Simulated Planetary Exploration in the Canadian Arctic |
topic_facet |
Aerospace Medicine |
description |
Dysregulation of the immune system has been shown to occur during space flight, although the detailed nature of the phenomenon and the clinical risks for exploration class missions has yet to be established. In addition, the growing clinical significance of immune system evaluation combined with epidemic infectious disease rates in third world countries provides a strong rationale for the development of field-compatible clinical immunology techniques and equipment. In July 2002 NASA performed a comprehensive field immunology assessment on crewmembers participating in the Haughton-Mars Project (HMP) on Devon Island in the high Canadian Arctic. The purpose of the study was to evaluate mission-associated effects on the human immune system, as well as to evaluate techniques developed for processing immune samples in remote field locations. Ten HMP-2002 participants volunteered for the study. A field protocol was developed at NASA-JSC for performing sample collection, blood staining/processing for immunophenotype analysis, wholeblood mitogenic culture for functional assessments and cell-sample preservation on-location at Devon Island. Specific assays included peripheral leukocyte distribution; constitutively activated T cells, intracellular cytokine profiles and plasma EBV viral antibody levels. Study timepoints were L-30, midmission and R+60. The protocol developed for immune sample processing in remote field locations functioned properly. Samples were processed in the field location, and stabilized for subsequent analysis at the Johnson Space Center in Houston. The data indicated that some phenotype, immune function and stress hormone changes occurred in the HMP field participants that were largely distinct from pre-mission baseline and post-mission recovery data. These immune changes appear similar to those observed in Astronauts following spaceflight. The sample processing protocol developed for this study may have applications for immune assessment during exploration-class space missions or in remote terrestrial field locations. The data validate the use of the HMP as a ground-based spaceflight/planetary exploration analog for some aspects of human physiology. |
author |
Crucian, Brian Lee, Pascal Widen, Raymond Jones, Jeff Stowe, Raymond Sams, Clarence Effenhauser, Rainer |
author_facet |
Crucian, Brian Lee, Pascal Widen, Raymond Jones, Jeff Stowe, Raymond Sams, Clarence Effenhauser, Rainer |
author_sort |
Crucian, Brian |
title |
Field Immune Assessment during Simulated Planetary Exploration in the Canadian Arctic |
title_short |
Field Immune Assessment during Simulated Planetary Exploration in the Canadian Arctic |
title_full |
Field Immune Assessment during Simulated Planetary Exploration in the Canadian Arctic |
title_fullStr |
Field Immune Assessment during Simulated Planetary Exploration in the Canadian Arctic |
title_full_unstemmed |
Field Immune Assessment during Simulated Planetary Exploration in the Canadian Arctic |
title_sort |
field immune assessment during simulated planetary exploration in the canadian arctic |
publishDate |
2006 |
url |
http://hdl.handle.net/2060/20060052407 |
op_coverage |
Unclassified, Unlimited, Publicly available |
long_lat |
ENVELOPE(-88.000,-88.000,75.252,75.252) |
geographic |
Arctic Devon Island |
geographic_facet |
Arctic Devon Island |
genre |
Arctic Devon Island |
genre_facet |
Arctic Devon Island |
op_source |
CASI |
op_relation |
Document ID: 20060052407 http://hdl.handle.net/2060/20060052407 |
op_rights |
Copyright, Distribution as joint owner in the copyright |
_version_ |
1766333824329842688 |